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IGP 304: Statistics for Biomedical Research (Spring 2010)

Instructors

Grading Assistant

Lectures

  • Tuesdays 10:00-11:30; D-2221 Medical Center North
  • Thursday 10:00-11:30; D-2221 Medical Center North
  • Exceptions:

Help sessions: by request to instructor

Class News

Prerequisites

  • Good command of standard algebra
  • Excellent skills in storing, moving, and organizing computer files and using a text editor

Discussion Board | Biostatistics Clinics (Friday is for basic science)

Syllabus | http://biostat.mc.vanderbilt.edu/survey/?94085624 Pre-course Survey

Textbook and reading materials

Software

Datasets for homework assignments

Homework and exams

  • Note: send your work directly to the grading assistant by e-mail or campus mail. See above for addresses.
  • Homework 1 using Rosner's FEV data
    • Questions 1-3 are due Friday, Jan 23
    • Questions 4-6 are due Friday, Jan 30
  • Homework 2 (Due Friday, Feb 13)
  • Homework 3 (Due Friday, Feb 27)
  • Homework 4 (Assigned 20Mar09 due 27Mar09)
  • NEW Homework 5 (due Apr 24)
  • Assignments from last year

Lectures

 
Date
To read/do before class
Topics
Instructor
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1
01/07 (Th)
Get the textbook and optionally download R and install the http://biostat.mc.vanderbilt.edu/twiki/bin/view/Main/StatBiomedResSyllabus#Software Rcmdr package or RExcel
Course description and overview; software
FH
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2
01/12 (Tu)
H 1-2.2; EMS 1-2; SN 15
Presentation of numerical data; Data import and entry; data types; spreadsheets from http://biostat.mc.vanderbilt.edu/twiki/pub/Main/DataTransmissionProcedures/Spreadsheetfromhell.xls hell and http://biostat.mc.vanderbilt.edu/twiki/pub/Main/DataTransmissionProcedures/spreadsheetfromheaven.xls heaven; 10 Data Entry Commandments
FH
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3
01/14 (Th)
H 2.2-2.5; EMS 3-4; LHSP Is statistics hard?
Descriptive/exploratory analysis; graphics
FH
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4
01/19 (Tu)
R 3.1-3.4, 3.8; EMS 5; http://stat.utilities.googlepages.com/tables.htm normal distribution calculator
Intro to probability; normal distribution
FH
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5
01/21 (Th)
R 5.5;R 6.1-6.4 The normal distribution
Normal distribution; estimation; intro to study design; regression to the mean
FH
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6
01/26 (Tu)
R 6.5-6.7; H 3.4.3; demonstration; CI applet
Estimating the sample mean; t distribution; confidence interval for a mean; sampling distribution of the sample standard deviation
FH
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7
01/28 (Th)
R 6.4,13.10 Experimental Design Presentation
Experimental Design; Quiz 2
FH
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8
02/04 (Th)
R 6.5, 6.11, CI applet, H 3.4.3-3.4.4
Distributions; Experimental Design; Sample size for a given precision (1-sample mean); Interpreting confidence intervals
FH
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9
02/9 (Tu)
R 7.1-7.8, H 3.1-3.4.1
Hypotheses; branches of statistics; Hypothesis tests: Introduction, errors, and one-sample inference
FH
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10
02/11 (Th)
R 7.10, 7.12-7.13, 8-8.5, H 3.4.2, 3.6-3.7.1 [skip 3.5 for now]
Power and sample size; more about confidence intervals; paired data; two-sample test for means
FH
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11
02/16 (Tu)
R 8.8, 8.10, H 3.7
Two-sample tests for means, continued;
FH
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12
02/26 (F)
H 3.8-3.10, H 3.5, R 6.8, 7.10
Problems with hypotheses and P-values; how to present results; extended examples of two-sample and one-sample t-tests; one-sample methods for proportions/probabilities
FH
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13
03/05 (F)
H 4, R 10.1-10.3, 10.5-10.6, 10.9, 13.3 PS software; Sample size for two proportions using PS
Two-sample methods for proportions/probabilities; Quiz 3
FH
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14
03/12 (F)
H 4.9; H 5, R 9
Comprehensive example comparing 2 proportions; Non Parametric Methods; Wilcoxon Signed rank test; Wilcoxon-Mann-Whitney two-sample rank sum test
FH
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15
03/19 (F)
H 6; R 11.1, 11.7, 11.8, 11.12; observer variability
Linear and rank correlation; assessing agreement
FH
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16
03/26 (F)
R 12; H 8
Analysis of Variance (ANOVA)
FH
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17
04/02 (F)
H 7; R 11
Simple and multiple regression models
FH
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18
04/9 (F)
H 10; MeasureChange
Quiz 4 ; Measuring change and transformations
FH
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19
04/16 (F)
ManuscriptChecklist
Last Class Review, answer questions related to final homework
FH
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04/23 (F)
No class
Homework 5 Due
FH
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I Attachment Action Size Date Who Comment
PSforProportions.pdfpdf PSforProportions.pdf manage 317 K 27 Mar 2008 - 07:31 ChrisSlaughter Using the PS software to calculate sample size for two proptions example
SampleSizePrecisionExample.pdfpdf SampleSizePrecisionExample.pdf manage 33 K 15 Apr 2008 - 09:27 ChrisSlaughter Example of sample size and precision for binary outcomes
binomial.pdfpdf binomial.pdf manage 226 K 25 Mar 2008 - 11:53 ChrisSlaughter Binomial probabilities for n=3 or 6 and p=.9
chisqr-Rcmdr.pdfpdf chisqr-Rcmdr.pdf manage 206 K 01 Apr 2008 - 09:10 ChrisSlaughter Screenshots for using R commander to do Chi2 and Fisher's tests
dox.rm.jcs.pdfpdf dox.rm.jcs.pdf manage 198 K 01 Apr 2008 - 12:47 ChrisSlaughter Experimental Design presentation
extranotes-proportions.pdfpdf extranotes-proportions.pdf manage 284 K 26 Mar 2008 - 15:36 ChrisSlaughter Scan of hand-written notes to cover CIs and hypothesis tests for a single proportion
logistic.linear.compare.pdfpdf logistic.linear.compare.pdf manage 1003 K 03 Apr 2008 - 12:21 ChrisSlaughter Comparison of interpretation for linear regression and logistic regression model
logistic.output.pdfpdf logistic.output.pdf manage 61 K 01 Apr 2008 - 09:11 ChrisSlaughter Output from a logistic regression model examining low birth weight
sepsis.csvcsv sepsis.csv manage 113 K 05 Feb 2008 - 14:47 ChrisSlaughter sepsis dataset for homework
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Topic revision: r134 - 10 Jan 2019, FrankHarrell
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