Daniel W. Byrne

Director of Artificial Intelligence Research, AVAIL

Advanced Vanderbilt Artificial Intelligence Laboratory

Senior Associate in Biostatistics


E-mail: daniel.byrne@vumc.org
Office Phone: 615.322.4228

Cell: 615.293-6739

Fax: 615.343.4924

Vanderbilt University School of Medicine
Department of Biostatistics
Room 11125, 11th Floor

2525 West End Avenue

Nashville, TN 37203-8354
Biostatistician, Author, Computer Scientist, Medical Researcher.

Daniel William Byrne is an American biostatistician, educator, and faculty member at Vanderbilt University best known for promoting randomized, pragmatic trials to assess how predictive models and artificial intelligence can be used to improve health outcomes in a learning healthcare system.

Born: January 21, 1958, (age 63), Brooklyn, New York, U.S.

Spouse: Loretta Byrne (m. 1985).

Children: Michael Paul Byrne, Virginia Leigh Byrne

Education: State University of New York at Albany, New York Medical College

Known for: The Cornelius Project -Real-time predictive modeling in healthcare,

Medical statistics, Design of experiments.


Randomization is much more important than complex statistical adjustments.

Randomization needs to be used much more often in medicine - this is our best option for improving health outcomes and lowering costs.

The learning healthcare system model, which randomizes patients during routine clinical care to one of two options - for which there is equipoise - is not only ethical but essential. In fact, not randomizing and not learning is unethical.

Books: Artificial Intelligence for Improved Patient Outcomes - Principles for Moving Forward with Rigorous Science (publication date: eBook 12/20/2022, print format 4/1/2023) https://www.amazon.com/dp/1975197933/


Publishing Your Medical Research



Slide Presentation about Publishing Your Medical Research:


Spotlight Article on Dan Byrne



Daniel William Byrne is a faculty member at Vanderbilt University in Nashville, TN. He has received multiple awards for his teaching, research and publications. He is an internationally recognized predictive analytics expert with over three decades experience in healthcare risk modeling to improve patient outcomes. His book is “Publishing Your Medical Research”.

Daniel Byrne is known for his Cornelius project, which is a translational research program of how predictive models can be used to focus health care prevention to reduce hospital complications and chronic diseases. He showed that real-time predictive models based on commonly available hospital data can be automated into a hospital's electronic health record to display a probability of future complications. Furthermore, he showed that it was possible to test whether using these predictive models to focus the hospital's prevention efforts improved patient outcomes using rigorous randomized controlled trials. His Cornelius team is currently developing and testing predictive models for hospital readmission, pressure ulcers, blood clots, catheter-associated urinary tract infections, patient falls, sepsis, and hypoglycemia. By applying rigorous scientific methods in a hospital setting this work is helping to define the modern learning health-care system and show how precision medicine can impact the health outcomes of patients.

Cornelius - Real-Time Predictive Modeling


Areas of Expertise

  • Artificial intelligence in medicine
  • Machine learning
  • The learning healthcare system
  • Predictive modeling
  • Big data analytics
  • Pragmatic trials
  • Precision medicine
  • EHR data mining
  • Consulting on biomedical problems, designing experiments and data analysis, clinical trials
  • Analyzing complex clinical research data sets
  • Designing, analyzing, and interpreting clinical trials data
  • Medical writing and publishing
  • Teaching biostatistics
  • Continuous quality improvement
  • Statistical graphics
  • Study design and bias
  • NIH grantsmanship

Research Interests

  • Clinical epidemiology
  • Worksite wellness/productivity
  • Outcomes research and health services research
  • Clinical pharmacology
  • Efficiency in clinical and translational research
  • Predicting and preventing complications
  • Teaching Videos
  • example_1_chi_square.xls: Excel spreadsheet with hypothetical data for the chi-square video.
  • Tools
  • spreadsheetfromheaven.xls: Spreadsheet from Heaven: Excel spreadsheet to demonstrate the proper way of entering data for a clinical research project.

  • Spreadsheetfromhell.xls: Spreadsheet from hell: Excel spreadsheet to demonstrate improper ways of entering data for a clinical research project.

  • 10DataEntryCommandments.doc: 10 Data Entry Commandments: How to enter research data in a computer spreadsheet for optimal statistical analysis.



  • American Statistical Association
  • Biometric Society (ENAR)

Software Expertise

  • R, Stata, SAS, SPSS, PS, nQuery Advisory ,CIA.


  • 1. Byrne DW: Publishing Your Medical Research; Wolters Kluwer, 2017
  • 2. Japanese Edition published in 2000 by Medical Sciences International, Ltd., Tokyo.
  • 3. Byrne DW. Artificial Intelligence for Improved Patient Outcomes - Principles for Moving Forward with Rigorous Science (Publication date: 2022)

Peer-Reviewed Publications

Original Investigations

1. Hodgson WJB, Mittelman A, Katz S, Friedland M, Berman H, Morgan J, Ahmed T, Byrne D: "Treatment of Colorectal Hepatic Metastases by Intrahepatic Chemotherapy Alone or as an Adjuvant to Complete or Partial Removal of Metastatic Disease" Annals of Surgery 1986;203(4):420-425.

2. Jabbour I, Savino JA, Agarwal N, Byrne D: "Pneumatic Antishock Garments Detrimental in Elderly with Diminished Myocardial Reserve." Current Surgery Vol 43(6):498-501 Nov-Dec 1986.

3. Savino JA, Cerabona T, Agarwal N, Byrne D: "Manipulation of Ascitic Fluid Pressure in Cirrhotics to Optimize Hemodynamic and Renal Function" Annals Surgery 1988;208 (4):504-511.

4. Agarwal N, Cayten CG, Savino JA, Stahl WM, Byrne DW, Murphy J. "Is Intensive Care Justified in the Injured Patient? Outcome vs Costs." Society of Critical Care Medicine 1989

5. Salzberg CA, Harmatz A, Byrne DW, D'Ariano G, Petro JA. "Development of a Computerized Data Base to Evaluate Pressure Ulcers" Decubitus (Advances in Wound Care) 1990;3(3):29-36.

6. Horowitz HW, Dworkin BM, Savino JA, Byrne DW, Pecora NA. "Central catheter-related infections: comparison of pulmonary artery catheters and triple lumen catheters for the delivery of hyperalimentation in a critical care setting." Journal of Parenteral and Enteral Nutrition 1990;14(6):588-592.

7. Cayten CG, Stahl WM, Byrne D, Murphy J, Agarwal N. Advanced Life Support for Hypotensive Trauma Patients. NAEMSP - National Association of EMS Physicians. Prehospital and Disaster Care Medicine, June 15,1990.

8. Cayten CG, Stahl WM, Byrne DW, Murphy JG. "A Comparison of Diagnostic Related Group Length of Stay Outliers: Motor Vehicle Crash Versus Penetrating Injuries" Accident Analysis and Prevention. 1991;23(4):317-322.

9. Levien DH, Gibbons S, Begos D, Byrne DW. "Survival After Resection of Carcinoma of the Splenic Flexure" Diseases of the Colon & Rectum 1991;34(5):401-403.

10.Cayten CG, Stahl WM, Murphy JG, Agarwal N, Byrne DW. "Limitations of the TRISS Method for Interhospital Comparisons: A Multihospital Study" The Journal of Trauma 1991;31(4):471-482; discussion 481-482.

11.Hodgson WJB, Morgan J, Byrne D. "Hepatic Resections for Primary and Metastatic Tumors Using the Ultrasonic Surgical Dissector" The American Journal of Surgery 1992;163:246-250.

12.Slupchynskyj OS, Berkower AS, Byrne DW, Cayten CG. "Association of skull base and facial fractures." Laryngoscope 1992;102(11):1247-1250.

13.Markle J, Cayten CG, Byrne DW, Moy F, Murphy JG. "Comparison between TRISS and ASCOT methods in controlling for injury severity" The Journal of Trauma 1992;33(2):326-332.

14.Cayten CG, Berendt BM, Byrne DW, Murphy JG, Moy FH. "A study of pneumatic antishock garments in severely hypotensive trauma patients" Journal of Trauma 1993;34(5):728-735; discussion 733-735.

15.Byrne DW. Increasing computer productivity while reducing costs. MD-Computing 1994;11(2):75.

16.Petro JA, Klein SA, Niazi Z, Salzberg CA, Byrne DW. Evaluation of ultrasound as a tool in the follow up of patients with breast implants: a preliminary, prospective study. Annals of Plastic Surgery 1994;32(6):580-587.

17.Horowitz HW, Pavia CS, Bittker S, Forseter G, Cooper D, Nadelman RB, Byrne D, Johnson RC, Womser GP. "Sustained cellular immune responses to Borrelia burgdorferi: Lack of correlation with clinical presentation and serology." Clinical & Diagnostic Laboratory Immunology, 1994 Jul;1(4):373-378.

18.Devine PA, Bracero LA, Lysikiewicz A, Evans R, Womack S, Byrne DW. Middle cerebral to umbilical artery Doppler ratio in post-date pregnancies. Obstetrics & Gynecology 1994;84(5):856-860.

19.Hodgson WJB, Byrne DW, Savino JA, Liberis G. Laparoscopic cholecystectomy. The early experience of surgical attendings compared with that of residents trained by apprenticeship. Surgical Endoscopy 1994;8(9):1058-1062.

20.Salzberg CA, Cooper-Vastola SA, Perez FJ, Viehbeck MG, Byrne DW. The effects of non- thermal pulsed electro-magnetic energy (Diapulse) on wound healing of pressure ulcers in spinal cord-injured patients: a randomized, double-blind study. Wounds 1995;7(1):11-16.

21.Salzberg CA, Cooper-Vastola SA, Perez FJ, Viehbeck MG, Byrne DW. The effects of non- thermal pulsed electro-magnetic energy (Diapulse) on wound healing of pressure ulcers in spinal cord-injured patients: a randomized, double-blind study. Ostomy Wound Management 1995;41(3):42-48.

22.Fletcher DJ, Taddonio RF, Byrne DW, Wexler LM, Cayten CG, Nealon SM, Carson W. Incidence of acute care complications in vertebral column fracture patients with and without spinal cord injury. Spine 1995;20(10):1136-1146.

23.Bracero LA, Cassidy S, Byrne DW. "Effect of gender on perinatal outcome in pregnancies complicated by diabetes." Gynecologic and Obstetric Investigation 1996;41:10-14.

24.Previdi JK, Cayten CG, Byrne DW. "Early Predictors of Sepsis in the Motor-Vehicle Crash Trauma Victim." Prehospital and Disaster Medicine 1996;11(1):27-36.

25.Salzberg CA, Byrne DW, Cayten CG, van Niewerburgh P, Murphy JG, Viehbeck M. "A new pressure ulcer risk assessment scale for individuals with spinal cord injury." American Journal of Physical Medicine & Rehabilitation 1996;75:96-104.

26.Del Savio GC, Zelicof SB, Wexler LM, Byrne DW, Reddy PD, Fish D, Ende K. "Preoperative nutritional status as a predictor of outcome after elective total hip replacement surgery." Clinical Orthopaedics and Related Research Clin Orthop 1996;326:153-161.

27.Bracero LA, Figueroa R, Byrne DW, Han HJ. "Comparison of umbilical Doppler velocimetry, nonstress testing, and biophysical profile in pregnancies complicated by diabetes." Journal of Ultrasound in Medicine. 1996;15(4): 301-308.

28. Niazi ZM, Salzberg CA, Byrne DW, Viehbeck M. Recurrence of initial pressure sores in spinal cord injured patients. Advances in Wound Care. 1997 May;10(3):38-42.

29. Salzberg CA, Byrne DW. A new pressure ulcer risk assessment scale for individuals with spinal cord injury. Am J Phys Med Rehabil 1996 Mar;75(2):96-104.

30. Bracero LA, Byrne DW. Doppler velocimetry discordancy of the uterine arteries in pregnancies complicated by diabetes. J Ultrasound Med 1997 Jun;16(6):387-393.

31. Salzberg CA, Byrne DW, Cayten CG, Kabir R, Niewerburgh PV, Viehbeck M, Long H, Jones EC. Predicting and preventing pressure ulcers in adults with paralysis. Adv Wound Care 1998 Sep;11(5):237-46.

32. Bracero LA, Byrne DW. Optimal maternal weight gain during singleton pregnancy. Gynecol Obstet Invest 1998;46(1):9-16.

33. Byrne DW. How to get your medical research paper published. The New Physician. Mar 1999:11-15.

34. Fitch JC, Geary KL, Mirto GP, Byrne DW, Hines RL. Heparin management test versus activated coagulation time during cardiovascular surgery: correlation with anti-Xa activity. J Cardiothorac Vasc Anesth 1999 Feb;13(1):53-7.

35. Fitch JC, Mirto GP, Geary KL, Byrne DW, Hines RL. Point-of-care and standard laboratory coagulation testing during cardiovascular surgery: balancing reliability and timeliness. J Clin Monit Comput 1999, May;15(3-4):197-204.

36. Bracero LA, Morgan S, Byrne DW. Comparison of visual and computer interpretation of nonstress tests in a randomized controlled trial. Am J Obstet.Gynecol. 1999; 181:1254-8.

37. Blumenfield M, Byrne DW. Development of posttraumatic stress disorders in urban emergency service workers. Medscape Mental Health 2(9), 1997. (online publication) http://oncology.medscape.com/Medscape/psychiatry/journal /1997 /v02.n09/mh3068.blumenfeld/mh3068.blumenfeld.html

38. Byrne DW. How to get your medical research paper published. The New Physician. Mar 1999:11-15.

39. Bracero LA, Roshanfekr D, Byrne DW. Analysis of antepartum fetal heart rate tracing by physician and computer. J Matern Fetal Med 2000;9(3):181-5.

40. Byrne DW. Common reasons for rejecting manuscripts at medical journals: A survey of editors and peer reviewers. Science Editor (formerly CBE Views) March-April 2000 Vol 23, No 2:39-44.

41. Serur E, Emeney PL, Byrne DW. Laparoscopic management of adnexal masses. JSLS 2001 Apr- Jun;5(2):143-51.

42. Dishy V, Sofowara GG, Xie HG, Kim RB, Byrne DW, Stein CM, Wood AJJ. The effect of common polymorphisms of the B2-adrenergic receptor on agonist-mediated vascular desensitization. N Engl J Med 2001;345:1030-1035.

43. Brown NJ, Abbas A, Byrne DW, Schoenhard JA, Vaughan DE. Comparative effects of estrogen and ACE inhibition on plasminogen activator inhibitor-1 in healthy postmenopausal women. Circulation 2002;105(3):304-9.

44. Rosenbaum DA, Pretorius M, Gainer JV, Byrne D, Murphey LJ, Painter CA, Vaughan DE, Brown NJ. Ethnicity affects vasodilation, but not endothelial tissue plasminogen activator release, in response to bradykinin. Arterioscler Thromb Vasc Biol 2002 Jun 1;22(6):1023-8

45. Liveris D, Wang G, Girao G, Byrne DW, Nowakowski J, McKenna D, Nadelman R, Wormser GP, Schwartz I. Quantitative Detection of Borrelia burgdorferi in 2-Millimeter Skin Samples of Erythema Migrans Lesions: Correlation of Results with Clinical and Laboratory Findings. J Clin Microbiol 2002 Apr;40(4):1249-53.

46. Liveris D, Wang G, Girao G, Byrne DW, Nowakowski J, McKenna D, Nadelman R, Wormser GP, Schwartz I. Quantitative detection of Borrelia burgdorferi in 2-millimeter skin samples of erythema migrans lesions: correlation of results with clinical and laboratory findings. J Clin Microbiol 2002 Apr;40(4):1249-53.

47. Bracero LA, Haberman S, Byrne DW. Maternal glycemic control and umbilical artery Doppler velocimetry. J Matern Fetal Neonatal Med. 2002;12(5)12:342-8.

48. Kuhn KP, Byrne DW, Arbogast PW, Doyle TP, Loyd JE, Robbins IM. Outcome in 91 Consecutive Patients with Pulmonary Arterial Hypertension Receiving Epoprostenol. Am J Respir Crit Care Med 2002;167(4):580-6.

49. Buchowski MS, Chen KY, Byrne D, Wang WC. Equation to estimate resting energy expenditure in adolescents with sickle cell anemia. Am J Clin Nutr 2002, Dec;76(6):1335- 44.

50. Bracero LA, Byrne DW. Ultrasound determination of chorionicity and perinatal outcome in twin pregnancies using dividing membrane thickness. Gynecol Obstet Invest. 2003;55(1):50-7.

51. Dishy V, Gupta S, Landau R, Xie HG, Kim RB, Smiley RM, Byrne DW, Wood AJJ, Stein CM. G-protein b3 subunit 825 C/T polymorphism is associated with weight gain during pregnancy. Pharmacogenetics. 2003 Apr;13(4):241-2.

52. Malave HA, Biaggioni I, Byrne DW, Vaughan DE, Murphey LJ, Brown NJ. Bradykinin and its metabolite bradykinin 1-5.Circulation. 2003.

53. Dignan R, Byrne DW. Aortic Valve Allograft Structural Deterioration is Associated with a Subset of Antibodies to Human Leukocyte Antigens. J Heart Valve Dis. 2003 May;12(3):382-90.

54. Lavely WC, Delbeke D, Greer JP, Morgan DS, Byrne DW, Price RR, Hallahan DE. FDG PET in the Follow-up Management of Patients with Newly-diagnosed Hodgkin’s and Non-Hodgkin’s Lymphoma after First-line Chemotherapy. Int J Radiat Oncol Biol Phys. 2003;57(2):307-315.

55. Tarquinio GT, Dittus RS, Byrne DW, Kaiser A, Neilson EG. Effect of performance-based compensation and faculty track on the clinical activity, research portfolio, and teaching mission of a large academic department of medicine. Acad Med. 2003 Jul;78(7):690-701.

56. Carcoana OV, Mathew JP, Davis E, Byrne DW, Hayslett JP, Hines RL, Garwood S. Manitol and Dopamine in Patients Undergoing Cardiopulmonary Bypass: A Randomized Clinical Trial. Anesth Analg. 2003 Nov;97(5):1222-9.

57. Sofowora GG, Dishy V, Muszkat M, Xie HG, Kim RB, Harris PA, Prasad HC, Byrne DW, Nair UB, Wood AJ, Stein CM. A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade. Clin Pharmacol Ther. 2003 Apr;73(4):366-71.

58. Lu CC, Diedrich A, Tung CS, Paranjape SY, Harris PA, Byrne DW, Jordan J, Robertson D. Water Ingestion as Prophylaxis Against Syncope. Circulation. Nov 2003. Circulation. 2003 Nov 25;108(21):2660-5. 2

59. Singleton CD, Robertson D, Byrne DW, Joos KM. Effect of posture on blood and intraocular pressures in multiple system atrophy, pure autonomic failure, and baroreflex failure. Circulation. 2003 Nov 11;108(19):2349-54.

60. Donahue BS, Byrne DW, Gailani D, George AL Jr. Tissue factor and platelet glycoprotein Ib-alpha alleles are associated with age at first coronary bypass operation. Anesthesiology. 2003 Dec;99(6):1287-94.46

61. Cohen JA, Arain A, Harris PA, Byrne DW, Holzman MD, Sharp KW, Richards WO. Surgical Trial Investigating Nocturnal Gastroesophageal Reflux and Sleep (STINGERS). Surgical Endoscopy 2003;17(3):394-400.

62. Haberman S, Bracero LA, Byrne DW. Spectral Doppler indices mapping of the umbilicoplacental circulation and pregnancy outcome. Gynecol Obstet Invest. 2004;58(1): 1-7.

63. Kuhn KP, Wickersham NE, Robbins IM, Byrne DW. Acute effects of sildenafil in patients with primary pulmonary hypertension receiving epoprostenol. Exp Lung Res. 2004 Mar;30(2):135-45.

64. Murff HJ, Rothman RL, Byrne DW, Syngal S. The impact of family history of diabetes on glucose testing and counseling behavior in primary care. Diabetes Care. 2004 Sep;27(9):2247-8.

65. Dishy V, Landau R, Sofowora GG, Xie HG, Smiley RM, Kim RB, Byrne DW, Wood AJ, Stein CM. Beta2-adrenoceptor Thr164Ile polymorphism is associated with markedly decreased vasodilator and increased vasoconstrictor sensitivity in vivo. Pharmacogenetics. 2004 Aug;14(8):517-22.

66. Lavely WC, Scarfone C, Cevikalp H, Li R, Byrne DW, Cmelak AJ, Dawant B, Price RR, Hallahan DE, Fitzpatrick JM. Phantom validation of coregistration of PET and CT for image-guided radiotherapy. Med Phys. 2004 May;31(5):1083-92.

67. Sofowora GG, Dishy V, Landau R, Xie HG, Prasad HC, Byrne DW, Smiley RM, Kim RB, Wood AJ, Stein CM. Alpha 1A-adrenergic receptor polymorphism and vascular response. Clin Pharmacol Ther. 2004 Jun;75(6):539-45.

68. Cho DG, Mulloy MR, Chang PA, Johnson MD, Aharon AS, Robison TA, Buckles TL, Byrne DW, Drinkwater DC Jr. Blockade of the extracellular signal-regulated kinase pathway by U0126 attenuates neuronal damage following circulatory arrest. J Thorac Cardiovasc Surg. 2004 Apr;127(4):1033-40.

69. Murff HJ, Byrne D, Syngal S. Cancer risk assessment: quality and impact of the family history interview. Am J Prev Med. 2004 Oct;27(3):239-45.

70. Richards WO, Torquati A, Holzman MD, Khaitan L, Byrne D, Lutfi R, Sharp KW. Heller myotomy versus Heller myotomy with Dor fundoplication for achalasia: a prospective randomized double-blind clinical trial. Ann Surg. 2004 Sep;240(3):405-12; discussion 412- 5.

71. Shah SA, Shankar V, Churchwell KB, Taylor MB, Scott BP, Bartilson R, Byrne DW, Christian KG, Drinkwater DC. Clinical outcomes of 84 children with congenital heart disease managed with extracorporeal membrane oxygenation after cardiac surgery. ASAIO J. 2005 Sep-Oct;51(5):504-7.

72. Garland EM, Winker R, Williams SM, Jiang L, Stanton K, Byrne DW, Biaggioni I, Cascorbi I, Phillips JA 3rd, Harris PA, Rudiger H, Robertson D. Endothelial NO synthase polymorphisms and postural tachycardia syndrome. Hypertension. 2005 Nov;46(5):1103-10. Epub 2005 Oct 3.

73. Ma J, Albornoz F, Yu C, Byrne DW, Vaughan DE, Brown NJ. Differing effects of mineralocorticoid receptor-dependent and -independent potassium-sparing diuretics on fibrinolytic balance. Hypertension. 2005 Aug;46(2):313-20.

74. Rosenbloom ST, Chiu KW, Byrne DW, Talbert DA, Neilson EG, Miller RA. Interventions to regulate ordering of serum magnesium levels: report of an unintended consequence of decision support. J Am Med Inform Assoc. 2005 Sep-Oct;12(5):546-53.

75. Wormser GP, McKenna D, Carlin J, Nadelman RB, Cavaliere LF, Holmgren D, Byrne DW, Nowakowski J. Brief communication: hematogenous dissemination in early Lyme disease. Ann Intern Med. 2005 May 3;142(9):751-5.

76. Kallianpur AR, Hall LD, Yadav M, Byrne DW, Speroff T, Dittus RS, Haines JL, Christman BW, Summar ML. The hemochromatosis C282Y allele: a risk factor for hepatic veno-occlusive disease after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2005 Jun;35(12):1155-64.

77. Xia Y, Hill KE, Byrne DW, Xu J, Burk RF. Effectiveness of selenium supplements in a low-selenium area of China. Am J Clin Nutr. 2005 Apr;81(4):829-34.

78. Raj SR, Biaggioni I, Yamhure PC, Black BK, Paranjape SY, Byrne DW, Robertson D. Renin-aldosterone paradox and perturbed blood volume regulation underlying postural tachycardia syndrome. Circulation. 2005 Apr 5;111(13):1574-82.

79. Taneja I, Diedrich A, Black BK, Byrne DW, Paranjape SY, Robertson D. Modafinil elicits sympathomedullary activation. Hypertension. 2005 Apr;45(4):612-8.

80. Willers ED, Newman JH, Loyd JE, Robbins IM, Wheeler LA, Prince MA, Stanton KC, Cogan JA, Runo JR, Byrne D, Humbert M, Simonneau G, Sztrymf B, Morse JA, Knowles JA, Roberts KE, McElroy JJ, Barst RJ, Phillips Iii JA. Serotonin Transporter Polymorphisms in Familial and Idiopathic Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2005 Dec 9.

81. !McAdam BF, Byrne D, Morrow JD, Oates JA. Contribution of cyclooxygenase-2 to elevated biosynthesis of thromboxane A2 and prostacyclin in cigarette smokers. Circulation. 2005 Aug 16;112(7):1024-9.

82. Murff HJ, Byrne D, Haas JS, Puopolo AL, Brennan TA. Race and family history assessment for breast cancer. J Gen Intern Med. 2005 Jan;20(1):75-80.

83. Toprak O, Cirit M, Yesil M, Byrne DW, Postaci N, Bayata S, Majchrzak KM, Esi E. Metabolic syndrome as a risk factor for contrast-induced nephropathy in non-diabetic elderly patients with renal impairment. Kidney Blood Press Res 2006;29:2-9.

84. Parekh AD, Trusler LA, Pietsch JB, Byrne DW, DeMarco RT, Pope JC 4th, Adams MC, Deshpande JK, Brock JW 3rd. Prospective, longitudinal evaluation of health related quality of life in the pediatric spina bifida population undergoing reconstructive urological surgery. J Urol. 2006 Oct;176(4 Pt 2):1878-82.

85. Murff HJ, Pichert JW, Byrne DW, Hedstrom C, Black M, Churchill L, Speroff T. General clinical research center staff nurse perceptions and behaviors regarding informed consent: results of a national survey. IRB. 2006 Jul-Aug;28(4):8-12.

86. Schadt CR, Cox KL, Tramontana MG, Byrne DW, Davis TL, Fang JY, Konrad PE, Padaliya B, Mutter RW, Gill CE, Richardson CR, Charles PD. Depression and intelligence in patients with Parkinson's disease and deep-brain stimulation. J Natl Med Assoc. 2006 Jul;98(7):1121-5.

87. Murphey LJ, Malave HA, Petro J, Biaggioni I, Byrne DW, Vaughan DE, Luther JM, Pretorius M, Brown NJ. Bradykinin and its metabolite bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humans. J Pharmacol Exp Ther. 2006 Sep;318(3):1287-92.

88. Buchowski MS, Majchrzak KM, Blomquist K, Chen KY, Byrne DW, Bachorowski JA. Energy expenditure of genuine laughter. Int J Obes (Lond). 2006 May 2

89. Burk RF, Norsworthy BK, Hill KE, Motley AK, Byrne DW. Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial. Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):804-10.

90. Agarwal HS, Churchwell KB, Doyle TP, Christian KG, Drinkwater DC Jr, Byrne DW, Taylor MB. Inhaled nitric oxide use in bidirectional Glenn anastomosis for elevated Glenn pressures. Ann Thorac Surg. 2006 Apr;81(4):1429-34.

91. Shibao C, Gamboa A, Diedrich A, Ertl AC, Chen KY, Byrne DW, Farley G, Paranjape SY, Davis SN, Biaggioni I. Autonomic Contribution to Blood Pressure and Metabolism in Obesity. Hypertension. 2007 Jan;49(1):5-6.

92. Johnston PE, France DJ, Byrne DW, Murff HJ, Lee B, Stiles RA, Speroff T. Assessment of adverse drug events among patients in a tertiary care medical center. Am J Health Syst Pharm. 2006 Nov 15;63(22):2218-27.

93. Tai JH, Udoji MA, Barkanic G, Byrne DW, Rebeiro PF, Byram BR, Kheshti A, Carter JD, Graves CR, Raffanti SP, Sterling TR. Pregnancy and HIV disease progression during the era of highly active antiretroviral therapy. J Infect Dis. 2007 Oct 1;196(7):1044-52.

94. Dzurik MV, Diedrich A, Black B, Paranjape SY, Raj SR, Byrne DW, Robertson D. Endogenous substance P modulates human cardiovascular regulation at rest and during orthostatic load. J Appl Physiol. 2007 Jun;102(6):2092-7.

95. Brown AM, Morrow JD, Limbird LE, Byrne DW, Gabbe SG, Balser JR, Brown NJ. Centralized oversight of physician-scientist faculty development at Vanderbilt: early outcomes. Acad Med. 2008 Oct;83(10):969-75.

96. Hebert PR, Coffey CS, Byrne DW, Scott TA, Fagard RH, Rottman JN, Murray KT, Oates JA. Treatment of Elderly Hypertensive Patients with Epithelial Sodium Channel Inhibitors Combined with a Thiazide Diuretic Reduces Coronary Mortality and Sudden Cardiac Death. J Am Soc Hypertens. 2008 Sep;2(5):355-365.

97. Mathew RP, Byrne DW, Linton MF, Vaughan DE, Fazio S, Russell WE. Evidence of metabolic syndrome in lean children with premature pubarche at diagnosis. Metabolism. 2008 Jun;57(6):733-40.

98. Tamaki R, Yoshikawa M, Shinomiya T, Hashimoto A, Kawaguchi M, Byrne DW, Kobayashi H. Acute administration of methamphetamine decreases the mRNA expression of diazepam binding inhibitor in rat brain. Tokai J Exp Clin Med. 2008 Apr 20;33(1):51-6.

99. Tamaki R, Yoshikawa M, Shinomiya T, Andoh H, Kawaguchi M, Hashimoto A, Byrne DW, Kobayashi H. 2008 Apr 20;33(1):46-50. Chronic administration of methamphetamine increases the mRNA expression of diazepam binding inhibitor in rat brain. Tokai J Exp Clin Med.

100. Birdwell KA, Ikizler MR, Sannella EC, Wang L, Byrne DW, Ikizler TA, Wright PF. Decreased antibody response to influenza vaccination in kidney transplant recipients: a prospective cohort study. Am J Kidney Dis. 2009 Jul;54(1):112-21.

101. Robbins IM, Newman JH, Johnson RF, Hemnes AR, Fremont RD, Piana RN, Zhao DX, Byrne DW. Association of the metabolic syndrome with pulmonary venous hypertension. Chest. 2009 Jul;136(1):31-6.

102. Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, Koura F, Whitten P, Margolis BD, Byrne DW, Ely EW, Rocha MG; SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA. 2009 Feb 4;301(5):489-99.

103. Xia Y, Hill KE, Li P, Xu J, Zhou D, Motley AK, Wang L, Byrne DW, Burk RF. Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects. Am J Clin Nutr. 2010 Sep;92(3):525-31.

104. Moss JR, Cofer S, Hersey S, Goudy S, Werkhaven J, Swanson E, Mantle C, Stowell N, Byrne D, Wang L, Labadie R. Comparison of clonidine, local anesthetics, and placebo for pain reduction in pediatric tonsillectomy. Arch Otolaryngol Head Neck Surg. 2011 Jun;137(6):591-7.

105. Maron DJ, Stone GW, Berman DS, Mancini GB, Scott TA, Byrne DW, Harrell FE Jr, Shaw LJ, Hachamovitch R, Boden WE, Weintraub WS, Spertus JA. Is cardiac catheterization necessary before initial management of patients with stable ischemic heart disease? Results from a Web-based survey of cardiologists. Am Heart J. 2011 Dec;162(6):1034-1043.

106. Byrne DW , Goetzel RZ , ! McGown PW, Holmes MC, Beckowski MS, Tabrizi MJ, Kowlessar N, Yarbrough MI. Seven-Year Trends in Employee Health Habits from a Comprehensive Workplace Health Promotion Program at Vanderbilt University. Journal of Occupational and Environmental Medicine. 2011 Dec,53(12):1372-1381.

107. Byrne DW, Biaggioni I, Bernard GR, Helmer TT, Boone LR, Pulley JM, Edwards T, Dittus RS. Clinical and Translational Research Studios: A Multidisciplinary Internal Support Program. Acad Med. 2012 Aug;87(8):1052-9.

108. Birdwell KA, Ikizler MR, Wang L, Byrne DW, Sannella EC, Wright PF, Ikizler TA. Seasonal maintenance of influenza vaccine-induced antibody response in kidney transplant recipients. Am J Nephrol. 2012;36(3):201-7.

109. Birdee GS, Byrne DW, ! McGown PW, Rothman RL, Rolando LA, Holmes MC, Yarbrough MI. Relationship between physical inactivity and health characteristics among participants in an employee-wellness program. J Occup Environ Med. 2013;55(5):514-9.

110. Rolando L, Byrne DW, ! McGown PW, Goetzel RZ, Elasy TA, Yarbrough MI. Health risk factor modification predicts incidence of diabetes in an employee population: results of an 8-year longitudinal cohort study. J Occup Environ Med. 2013 Apr;55(4):410-5.

111. Pezawas T, Diedrich A, Winker R, Robertson D, Richter B, Wang L, Byrne DW, Schmidinger H. Multiple autonomic and repolarization investigation of sudden cardiac death in dilated cardiomyopathy and controls. Circ Arrhythm Electrophysiol. 2014 Dec;7(6):1101-8.

112. McGregor TL, Jones DP, Wang L, Danciu I, Bridges BC, Fleming GM, Shirey-Rice J, Chen L, Byrne DW, Van Driest SL. Acute Kidney Injury Incidence in Noncritically Ill Hospitalized Children, Adolescents, and Young Adults: A Retrospective Observational Study. Am J Kidney Dis. 2015 Aug 26.

113. Burk RF, Hill KE, Motley AK, Byrne DW, Norsworthy BK. Selenium deficiency occurs in some patients with moderate-to-severe cirrhosis and can be corrected by administration of selenate but not selenomethionine: a randomized controlled trial. Am J Clin Nutr. 2015 Oct 14.

114. Noto MJ, Domenico HJ, Byrne DW, Talbot T, Rice TW, Bernard GR, Wheeler AP. Chlorhexidine bathing and health care-associated infections: a randomized clinical trial. JAMA. 2015 Jan 27;313(4):369-78.

115. Landsperger JS, Semler MW, Wang L, Byrne DW, Wheeler AP. Outcomes of Nurse Practitioner- Delivered Critical Care: A Prospective Cohort Study. Chest. Published online December 31, 2015.

116. Semler MW, Wanderer JP, Ehrenfeld JM, Stollings JL, Self WH, Siew ED, Wang L, Byrne DW, Shaw AD, Bernard GR, Rice TW Balanced Crystalloids versus Saline in the Intensive Care Unit: The SALT Randomized Trial. SALT Investigators and the Pragmatic Critical Care Research Group. Am J Respir Crit Care Med. 2016 Oct 17.

117. Semler MW, Rice TW, Shaw AD, Siew ED, Self WH, Kumar AB, Byrne DW , Ehrenfeld JM, Wanderer JP. Identification of Major Adverse Kidney Events Within the Electronic Health Record. J Med Syst. 2016 Jul;40(7):167.

118. Hacker ML, Currie AD, Molinari AL, Turchan M, Millan SM, Heusinkveld LE, Roach J, Konrad PE, Davis TL, Neimat JS, Phibbs FT, Hedera P, Byrne DW , Charles D. Subthalamic Nucleus Deep Brain Stimulation May Reduce Medication Costs in Early Stage Parkinson's Disease. J Parkinsons Dis. 2016;6(1):125-31.

119. Byrne DW, Rolando LA, Aliyu MH, McGown PW, Connor LR, Awalt BM, Wang L, Yarbrough MI. Modifiable Healthy Lifestyle Behaviors: 10-Year Health Outcomes From a Health Promotion Program. Amer J Preventive Med. Nov 2016.

120. Semler MW, Wanderer JP, Ehrenfeld JM, Stollings JL, Self WH, Siew ED, Wang L, Byrne DW, Shaw AD, Bernard GR, Rice TW; SALT Investigators * and the Pragmatic Critical Care Research Group; SALT Investigators. Balanced Crystalloids versus Saline in the Intensive Care Unit. The SALT Randomized Trial. Am J Respir Crit Care Med. 2017 May 15;195(10):1362-1372.

121. Byrne DW, Rolando LA, Aliyu MH, McGown PW, Connor LR, Awalt BM, Holmes MC, Wang L, Yarbrough MI. Modifiable Healthy Lifestyle Behaviors: 10-Year Health Outcomes From a Health Promotion Program. Am J Prev Med. 2016 Dec;51(6):1027-1037.

122. Semler MW, Self WH, Wang L, Byrne DW, Wanderer JP, Ehrenfeld JM, Stollings JL,Kumar AB, Hernandez A, Guillamondegui OD, May AK, Siew ED, Shaw AD, Bernard GR, Rice TW; Isotonic Solutions and Major Adverse Renal Events Trial (SMART) Investigators; Pragmatic Critical Care Research Group. Balanced crystalloids versus saline in the intensive care unit: study protocol for a cluster-randomized, multiple-crossover trial. Trials. 2017 Mar 16;18(1):129.

123. Self WH, Semler MW, Wanderer JP, Ehrenfeld JM, Byrne DW, Wang L, Atchison L, Felbinger M, Jones ID, Russ S, Shaw AD, Bernard GR, Rice TW. Saline versus balanced crystalloids for intravenous fluid therapy in the emergency department: study protocol for a cluster-randomized, multiple-crossover trial. Trials. 2017 Apr 13;18(1):178.

124. Wang L, McGregor TL, Jones DP, Bridges BC, Fleming GM, Shirey-Rice J, McLemore MF, Chen L, Weitkamp A, Byrne DW, Van Driest SL. Electronic health record-based predictive models for acute kidney injury screening in pediatric inpatients. Pediatr Res. 2017 Sep;82(3):465-473.

125. Swift MD, Aliyu MH, Byrne DW, Qian K, McGown P, Kinman PO, Hanson KL, Culpepper D, Cooley TJ, Yarbrough MI. Emergency Preparedness in the Workplace: The Flulapalooza Model for Mass Vaccination. Am J Public Health. 2017 Sep;107(S2):S168-S176.

126. Semler MW, Self WH, Wanderer JP, Ehrenfeld JM, Wang L, Byrne DW, Stollings JL,Kumar AB, Hughes CG, Hernandez A, Guillamondegui OD, May AK, Weavind L, Casey JD, Siew ED, Shaw AD, Bernard GR, Rice TW; SMART Investigators and the Pragmatic Critical Care Research Group. Balanced Crystalloids versus Saline in Critically Ill Adults. N Engl J Med. 2018 Mar 1;378(9):829-839.

127. Self WH, Semler MW, Wanderer JP, Wang L, Byrne DW, Collins SP, Slovis CM, Lindsell CJ, Ehrenfeld JM, Siew ED, Shaw AD, Bernard GR, Rice TW; SALT-ED Investigators. Balanced Crystalloids versus Saline in Noncritically Ill Adults. N Engl J Med. 2018 Mar 1;378(9):819-828.

Reviews, Case Reports, Letters, Editorials

128.Byrne DW, Salzberg CA. "Major risk factors for pressure ulcers in the spinal cord disabled: a literature review.” Spinal Cord (Paraplegia). 1996;34(5):255-263.

Book Reviews

129. Byrne DW. Book review of “Essential Medical Statistics” by Kirkwood. Teaching Statistics in the Health Sciences Newsletter. Jan 2004.

130. Byrne DW. Book review of “Statistics with Confidence” by Altman. Teaching Statistics in the Health Sciences Newsletter. June 2004.

131. Byrne DW. Book review of “SPSS 12.0 Guide to Data Analysis” by Norusis. Teaching Statistics in the Health Sciences Newsletter. Dec 2004.

132. Byrne DW. Book review of “Dicing with Death: Chance, Risk and Health” by Senn. Teaching Statistics in the Health Sciences Newsletter. Feb 2005.

133. Byrne DW. Book review of “Introductory Statistics with R” by Dalgaard. Teaching Statistics in the Health Sciences Newsletter. June 2005.

134. Byrne DW. Book review of “Statistical Methods in Medical Research” by Armitage. Teaching Statistics in the Health Sciences Newsletter. Dec 2005.

135. Byrne DW. Book review of “Teacher Man” by McCourt. Teaching Statistics in the Health Sciences Newsletter. June 2006.

136. Byrne DW. Book review of “Study Design and Statistical Analysis” by Katz. Teaching Statistics in the Health Sciences Newsletter. Dec 2006.

Selected Recent Posters:

1. Byrne DW. Statistical methods and software used in studies published by two leading medical journals. General Clinical Research Centers Annual Meeting, Arlington, Virginia. March 11, 2000.

2. Byrne DW. Improving the quality of biostatistics teaching. General Clinical Research Centers Annual Meeting, Arlington, Virginia. March 9, 2001.

3. Byrne DW, Arbogast P, Gautam S, Dittus R. “Improving the Quality of an Introductory Biostatistics Course for Physicians” 2002 Joint Statistical Meetings (NY, NY), American Statistical Association Section on Teaching Statistics in the Health Sciences, (Best Contributed Poster), August 2002.

4. Dittus RS, Byrne DW, Biaggioni I, Bernard GR, Helmer TT, Boone LR, Pulley JM, Edwards T. Clinical and Translational Research Studios: An Interdisciplinary Model. AAMC, September 2012.

5. Byrne DW, Domenico H, Wang L, Bernard GR. Using Biostatistics to Improve Health Outcomes - The Last Mile of a Learning Healthcare System. 2018 ENAR (Atlanta, GA).

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