My project is an RCT comparing the pain patients experience with steroid injections with and without lidocaine. We would like assistance with a power analysis to determine how many patients we need to enroll. Data collection underway
Our project will compare 25 subjects with severe OAB who have not yet undergone advanced therapies and 25 healthy controls. Baseline data will be collected in the form of demographic information, subject voiding diaries and multiple validated questionnaires as well as uroflow and post-void residual data. Subjects will then present for an fMRI session using a 7T magnet which is available in a suite fitted for patient care and clinical investigation at the Vanderbilt University Institute of Imaging Science. Subjects will undergo a resting state MRI with an empty bladder and then a foley catheter will be inserted. Using an infusion pump, fMRI sequences will be then obtained at increasing levels of bladder fullness in 50cc increments and the subject will alert investigators to a sensation of urgency.
Would like to address specific biostats plan for analysis.
We are hoping to gain insight into the analysis and interpretation of finding regarding a publication on cyclically loaded bone samples.
Our project is testing whether immune gene signatures of thyroid tumors can be used to predict characteristics such as malignancy, histologic type, tumor stage, and lymph node metastasis. We have collected clinical samples, performed RNA seq, and used TIMER, TIDE, and CIBERSORT software to make estimations of tumor-immune infiltrates. We are currently collecting mutation, lymph node, and tumor stage data. We have used logistic regression in R to identify a number of correlations between specific immune infiltrates and thyroid disease types, and we like to learn more about statistical approaches that might work best for our data.
VICTR Biostatistics voucher
Mentor confirmed
Suggest looking at ordinal or alternate measures to identify associations. Will collect more data and return to clinic.
In this project, we will conduct a geospatial analysis of non-fatal overdose rates as compared to naloxone distribution, opioid prescribing, and population demographics at the county level in the state of Massachusetts. The demographics that will be examined include race/ethnicity, age, percent of the population over age 65, primary industry in the area, and gender. We will examine the distribution of overdoses between rural, urban, and suburban areas to determine if there are any significant patterns by area types based on increasing percent of overdose rates. Lastly, we will conduct proximity analysis by mapping treatment center locations to examine if overdose rates increase as distance to treatment increase (note, we are still working on getting the data for this). Through this research, we hope to gain a better understanding of the most at-risk populations in the opioid epidemic.
We want to review our data analysis strategy of using Geographic Weighted Regression and stratification of overdoses by geographic areas. We want to discuss data analysis strategy for be mapping treatment center locations to see if areas where treatment is not close by have higher overdose.
Meeting notes: 14 counties in MA. Outcome of non-fatal/fatal overdose rates. Interested in demographics, naloxone prescribing, geographic factors. Identifiy populations at risk by location. 2010-2017 years available. Recommend descriptive and visual output. May consider a model looking at Prob(dying) ~ demographics + variable of interest. Splines can be used when continuous variables don't behave the same way across all values and may affect the probability differently at different points along the scale ?rcs for restricted cubic splines.
We are submitting an initial request for industry funding for a randomized phase II study, and need to determine an efficient study design (accrual will be slow).
In simple terms, patients with resectable brain metastases undergo surgery, then stereotactic radiosurgery (SRS), then systemic therapy. Osimertinib is a new first-line drug for EGFR-mutated non-small cell lung cancer and it has much higher CNS penetration. The aim of the trial is to assess if treatment with surgery+osimertinib is equivalent/non-inferior to surgery+SRS+osimertinib with respect to local brain recurrence (either proportion at 1-year or time-to-local recurrence).
Mentor confirmed
Meetings notes: Estimate local recurrence rates lower and better QoL with SRS (precise application of radiation) compared to surgery alone. Interested in applying new drug to everbody. Randomizing to radiation or not. In slightly different population, recurrence ~28%. Estimated 1 person per month. Suggest working from how many people and determine what difference can be detected based on that sample size.
I took over a project, and there was already a sample size in the approved IRB protocol. I need assistance in how they did the power calculation for a study. Design complete but no enrollment/data collection
We plan to conduct a PheWAS analysis of two SNPs (rs291102, rs2275531) in the PIGR gene. The MAF are 11.5% and 37.97% respectively. rs291102 has been associated with IgA nephropathy and we hypothesize other disease associations. Record Counter reports 30313 patients with genotyping information for both SNPs.
Prior to requesting data, we want to discuss statistical analysis methods.
Assessing the effect of smoking on IPF disease phenotype, specifically the effect of smoking and latency between quit date and diagnosis. Progression and severity assessed using continuous variable of PFT parameters and survival. Need help with eliminating survival bias and lead-time bias.
Protocol with no expected funding support, Abstract
Mentor confirmed
Meeting notes: Peeople diagnosed with IPF and have smoking habits. Also looking at people at risk. Looking at smoking/non-smoking and quitting association with outcome. Number of pack-years. Data shows relationship with protective nature of quitting. Bias problems: smokers more likely to be seen, more likely to have pack-years. If you quit smoking, does your trajectory change?
For the at-risk cohort study, can do a simple survival analysis to determine time to disease progression.Could consider competing risks models or using "death or disease" as outcome for supplemental analysis. Suggest 2 separate cohort studies. For those diagnosed, time to death. For those at risk, time to disease.
Mentor to attend.
Outcome: Abstract with no expected funding support
Outcome: Other
sahana.nagabhushan.kalburgi@vanderbilt.edu |
Mentor to attend via phone.
Outcome: Protocol with no expected funding support
PD-L1 is upregulated in several cancers such as melanoma, leukemia and nonsmall cell lung cancer (NSCLC). This over expression allows cancer cells to escape elimination by tumor specific cytotoxic T lymphocytes. PD-L1 is measured in a variety of tumor types to help guide best therapy. We will review those test results with the goal of determine whether there is an association between tobacco exposure and PD-L1 expression.
Attending this clinic for assistance in statistical design for a Pfizer grant: http://www.pfizer.com/files/IGLC_CGA18AI1_GAS.pdf Project design: we will be giving inpatient Clinical Providers feedback on antimicrobial utilization (targeting overall antimicrobial use and specific high risk antimicrobials). We would like to examine if overall use and use of specific antimicrobials decrease after the feedback period.
Looking at behavioral logs for potentially suicidal patients. Data includes 2700 patients over 3 years who meet crteria of psychiatric, sitter service or dedicated manager inclusion criteria.
* Recommend applying for VICTR Studio and VICTR Award for biostatistics support (90 hours). Email draft of proposal to Chang Yu.