Biostatistics Weekly Seminar

Clustered data are common in practice. Clustering arises when subjects are measured repeatedly, or subjects are nested in groups (e.g., households, schools). It is often of interest to evaluate the correlation between two variables with clustered data. There are three commonly used Pearson correlation coefficients (total, between-, and within-cluster), which together provide an enriched perspective of the correlation. However, these Pearson correlation coefficients are sensitive to extreme values and skewed distributions. They also depend on the scale of the data and are not applicable to ordered categorical data. Current non-parametric measures for clustered data are only for the total correlation. Here we define population parameters for the between- and within-cluster Spearman rank correlations. The definitions are natural extensions of the Pearson between- and within-cluster correlations to the rank scale. We show that the total Spearman rank correlation approximates a weighted sum of the between- and within-cluster Spearman rank correlations, where the weights are functions of rank intraclass correlations of the two random variables. We also discuss the equivalence between the within-cluster Spearman rank correlation and the covariate-adjusted partial Spearman rank correlation. Furthermore, we describe estimation and inference for the three Spearman rank correlations, conduct simulations to evaluate the performance of our estimators, and illustrate their use with data from a clustered randomized trial and a longitudinal biomarker study.

Hybrid: Location and Zoom Link to Follow
9 February 2024
1:30pm