Qingxia (Cindy) Chen, PhD

Professor and Vice Chair for Education, Department of Biostatistics

Biomedical Informatics, and Ophthalmology & Visual Sciences

Picture of Qingxia Chen
E-mail: cindy dot chen at vumc.edu
Office: 2525 West End, Ste. 11126
Vanderbilt University School of Medicine
Department of Biostatistics
2525 West End, Ste. 11126
Nashville, TN 37203-2158

Research Interests

Dr. Chen’s research lands on both novel statistical research and impactful biomedical research. Currently, her statistical research focuses on missing data, survival analysis (especially time-varying effect and treatment switching), Bayesian methods in big data, and penalized approach for 1<n/p<10. She is also devoted to develop statistical method in using electronic health records (EHRs) and genetics information in precision medicine. Her other significant biomedical research areas include cancer, ophthalmology, infection disease, cardiovascular diseases, and suicide
  • Statistical Analysis with Missing Data
  • Survival Data Analysis
  • Electronic Medical Record
  • Treatment switching/Noncompliance
  • Bayesian Statistics
  • Semiparametric/Nonparametric Method, Robust Analysis
  • and More

Information for Collaborators

Curriculum Vitae

CV (updated Feb 2022)

Active Grants Support

  • 1R01CA237895-01A1: Time-dependent and Bidirectional Effect of Oxidative Stress - a Missing Piece of the Free Radical Theory of Cancer and its Potential Implications.
Role: Principal Investigator (with Gong Yang at Vanderbilt University Medical Center). Period: 12/01/2019 -- 11/30/2024
  • 1R37CA237452-01A1: Prediction of Anti-Cancer Medication Discontinuation via Patient Portal Messages and Structured Electronic Medical Records.
Role: Co-Investigator (PI: Yin). Period: 05/01/2020 – 04/30/2024
  • 5U2COD23196-02: Precision Medicine Initiative Participants Preparatory/Prototyping Initiative ("all of us").
Role: Co-Investigator (PI: Harris/Roden). Period: 07/06/2016 -- 12/31/2022
  • U24 CA194215-01A1: Advancing Cancer Pharmacoepidemiology Research Through EHRs and Informatics.
Role: Co-Investigator (PI: Warner). Period: 09/01/2016 -- 08/31/2022
  • VUMC75977/64793: Opioid Overdose Predictive Modeling.
Role: Biostatistician (PI: Walsh). Period: 11/01/2019 -- 08/31/2021
  • VUMC75977/64793: To adapt NLP to ascertain suicidality from individual notes, validate it to predict death from suicide, and generalize the approach to secondary outcomes.
Role: Biostatistician (PI: Walsh). Period: 02/01/2021 -- 01/31/2023

Complete Grants Support (Principle Investigator Only)

  • Department Award: Improving Data Quality for Time-varying Measurements in Electronic Medical Record. Period: 01/01/2018 -- 06/30/2020
  • Subcontract Award: Center for Innovative Clinical Trials at UNC. Period: 09/01/2013-8/10/2015
  • R21 HL097334-01A2: A New Approach to Correct Verification Bias Using Auxiliary Information. Period: 12/20/2010-11/30/2014


Pubmed here

Selected Papers:
  1. Chen Q., Ibrahim J. G. (2006) "Semiparametric Models for Missing Covariate and Response Data in Regression Models". Biometrics, 62, 177-184.
  2. Chen Q., Zeng, D., Ibrahim, J. G. (2007) "Sieve Maximum Likelihood Estimation for Missing Covariates in Regression Models". Journal of the American Statistical Association. Vol 102, 1309-1318.
  3. Chen Q., Ibrahim, J. G., Chen, M.-H., Senchaudhuri, P. (2008) ''Theory and Inference for Regression Models with Missing Response and Covariates". Journal of Multivariate Analysis. 99(6). 1302-31.
  4. Zeng, D., Chen Q., Ibrahim, J. G. (2009) "Gamma frailty transformation models for multivariate survival times''. Biometrika. 96(2):277-291.
  5. Janssen K.J.M., Vergouwe Y., Donders A.R.T., Harrell F.E. Jr., Chen Q., Grobbee D.E., Moons K.G.M. (2009) "Dealing with missing predictor values when applying clinical prediction models". Clin Chem. 2009 May;55(5):994-1001.
  6. Janssen, K.J.M., Donders, A.R.T., Harrell, F.E., Vergouwe, Y., Chen Q., Grobbee, D.E., Moons, K.G.M. (2010) "Missing covariate data in medical research: To impute is better than to ignore ". J Clin Epidemiol. 63(7):721-7.
  7. Zeng, D., Chen Q. (2010) "Adjustment for Missingness Using Auxiliary Information in Semiparametric Regression". Biometrics. 66(1):115-22.
  8. Frisse M., Johnson K., Nian H., Davidson C., Gadd C.S., Unertl K., Turri P.A., Chen Q., (2011) ``The financial impact of health information exchange on emergency department care''. Am Med Inform Assoc. 2012 May 1;19(3):328-33. PMID: 22058169.
  9. Zeng D., Chen Q., Chen M-H, Ibrahim J.G., Amgen Research Group (2012) "Estimating Treatment Effects with Treatment Crossovers via Semi-Competing Risks Models: An Application to a Colorectal Cancer Study''. Biometrika. 2012 99 (1): 167-184. Real Data Analysis codes; Simulation I in zip
  10. Wu H.*, Chen Q.*^, Ware L.B., Koyama T. (2012) "A Bayesian Approach for Generalized Linear Model with an Independent Biomarker Measurement Variable Subject to Detection-Limit -- an Application to Acute Lung Injury". Journal of Applied Statistics. 39(8): 1733-1747. * Co-first author; ^ corresponding author.
  11. Zhang Y., Chen Q., Chen M.-H., Ibrahim J.G., Zeng D., Pan Z, and Xue X. "Bayesian Analysis of Survival Data with Semi-Competing Risks and Treatment Switching''. The 2012 ICSA Applied Statistics Symposium Proceedings.
  12. Chen Q., Zeng D., Ibrahim J.G., Akacha M., and Schmidli H., (2013) "Estimating Time-varying Effects for Overdispersed Recurrent Events Data with Treatment Switching''. Biometrika 2013; 100 (2): 339-354. NIHMSID 529973
  13. Chen Q., Chen M.-H., Ohlssen D., Ibrahim J.G. "Bayesian Modeling and Inference for Clinical Trials with Partial Retrieved Data Following Drop-out''. Statistics in Medicine. 2013; 32(24): 4180-4195.
  14. Chen Q., Ibrahim, J. G. "A Note on the Relationships Between Multiple Imputation, Maximum Likelihood and Fully Bayesian Methods for Missing Responses in Linear Regression Models". Statistics and Its Interface. 2014; 6(3): 315-324.
  15. Zhang Y., Chen M.-H., Ibrahim J.G., Zeng D., Chen Q., Pan Z, and Xue X. " Bayesian gamma frailty models for survival data with semi-competing risks and treatment switching''. Lifetime Data Analysis. 2014; 20(1): 76-105.
  16. Chen Q., Wu H, Ware LB, Koyama T. "A Bayesian approach for the Cox proportional hazards model with covariates subject to detection limit". International Journal of Statistics in Medical Research. 2014; 3(1): 32-43.
  17. Chen Q., May RC, Ibrahim JG, Chu H, Cole SR. "Joint modeling of longitudinal and survival data with missing and left-censored time-varying covariates". Stat Med. 2014 Nov 20;33(26):4560-76.
  18. Zhu H., Ibrahim J.G., Chen Q. "Bayesian Case-deletion Model Complexity and Information Criterion". Statistics and Its Interface. 2014; 7(4); 531-42.
  19. Chen Q., Griffin M.R., Nian H., Zhu Y., Williams J.V., Edwards K.M, Talbot H.K. (2015) "Influenza Vaccine Prevents Medically-Attended Influenza-Associated Acute Respiratory Illness in Adults 50 Years or Older". J Infect Dis. 2015 Apr 1;211(7):1045-50.
  20. Chen Q., Zeng D., Ibrahim J.G., Chen M.-H., Pan Z., Xue X. "Quantifying the Average of the Time-varying Hazard Ratio via a Class of Transformations". Lifetime Data Anal. 2015 Apr;21(2):259-79.
  21. Chen Q., Nian H, Zhu Y, Talbot HK. (2016) "Reply to Letter to the Editor: Reply to Sullivan et al." Vaccine. Volume 34, Issue 39, 4647–8.
  22. Chen Q., Nian H., Zhu Y., Talbot H.K., Griffin M.R. and Harrell F.E. Jr "Too Many Covariates and Too Few Cases? -- A Comparative Study". Stat Med.2016 Nov 10;35(25):4546-4558.
  23. Li R., Cheng Y., Chen Q., Jason F. (2017) "Quantile Association for Bivariate Survival Data". Biometics. 2017 Jun; 73(2):506-516.
  24. Diao G, Zeng D, Ibrahim JG, Rong A, Lee O, Zhang K, Chen Q. (2017) "Statistical design of noninferiority multiple region clinical trials to assess global and consistent treatment effects". J Biopharm Stat. 2017 Feb 13:1-12. PMID:28296570
  25. Chen Q., Harrell F.E. (2019) Comment: Penalized Spline of Propensity Methods for Treatment Comparison. Journal of the American Statistical Association. To appear.
  26. Hughey J.J., Rhoades S.D., Fu D.Y., Bastarache L., Denny J.C., Chen Q. (2019) Cox regression increases power to detect genotype-phenotype associations in genomic studies using the electronic health record. BMC Genomics. 2019 Nov 4;20(1):805. doi: 10.1186/s12864-019-6192-1.
  27. Xu H., Li J., Jiang X., and Chen Q. (2020) Electronic health records for drug repurposing: current status, challenges, and future directions. Clinical Pharmacology & Therapeutics. Clin Pharmacol Ther. 2020 Feb 3. doi: 10.1002/cpt.1769.
  28. Chen Q., Zhang F., Chen M.-H., Cong X.J. (2020) Estimation of Treatment Effects and Model Diagnostics with Two-way Time-Varying Treatment Switching: an application to a head and neck study, Lifetime Data Analysis 26(4), 685-707 (2020). PMID: 32125594.
  29. Zhang F., Chen M.-H., Cong X.J., Chen Q. (2020) Assessing Importance of Biomarkers: a Bayesian Joint Modeling Approach of Longitudinal and Survival Data with Semicompeting Risks, Statistical Modelling Journal July 27, 2020.
  30. Irlmeier R, Hughey JJ, Bastarache L, Denny JC, Chen Q (2022) On the Robustness of Cox Model to the Delayed Event Times and Its Application to PheWAS Study, Bioinformatics, 2022 Feb 14:btac086. doi: 10.1093/bioinformatics/btac086. Online ahead of print. PMID: 35157022


Epid 323 (Spring 2011-2012): Design and Analysis with Time-to-Event Data

Bios 323 (Fall 2012-2020): Applied Survival Analysis


PhD in Biostatistics 2005
Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill
Dissertation: Theory and Inference for Parametric and Semiparametric Methods in Missing Data Problem

MS in Statistics 2001
Department of Statistics, School of Arts and Sciences, University of Pittsburgh

BA in Statistics 1999
Department of Statistics and Finance, University of Science and Technology of China, P.R.China

Epid 323 (Spring 2011): Design and Analysis with Time-to-Event Data

Topic attachments
I Attachment Action Size Date Who Comment
CV_09282012.pdfpdf CV_09282012.pdf manage 54.2 K 17 Oct 2012 - 11:15 QingxiaChen  
Ch1.pdfpdf Ch1.pdf manage 138.4 K 21 Aug 2014 - 12:58 QingxiaChen  
Cindy_061510.pdfpdf Cindy_061510.pdf manage 93.9 K 25 Mar 2011 - 16:08 QingxiaChen  
IMG_0837.JPGJPG IMG_0837.JPG manage 1962.9 K 13 Feb 2019 - 11:07 QingxiaChen  
IMG_1261_2.jpgjpg IMG_1261_2.jpg manage 130.3 K 12 Dec 2018 - 15:28 QingxiaChen  
Lab10.pdfpdf Lab10.pdf manage 72.3 K 07 Nov 2012 - 12:40 HuiNian  
Lab12.txttxt Lab12.txt manage 3.4 K 24 Nov 2012 - 20:20 HuiNian  
Lab9.pdfpdf Lab9.pdf manage 77.5 K 29 Oct 2012 - 14:30 HuiNian  
Schedule.pdfpdf Schedule.pdf manage 39.3 K 21 Aug 2014 - 11:42 QingxiaChen Schedule for Bios 323 (Fall 2014)
Schedule.xlsxls Schedule.xls manage 12.0 K 21 Aug 2014 - 10:33 QingxiaChen Schedule for Bios 323 (Fall 2014)
Syllabus.pdfpdf Syllabus.pdf manage 45.6 K 21 Aug 2014 - 10:32 QingxiaChen Syllabus for Bios 323 (Fall 2014)
VTEU.projectsummary.0406.xlsxls VTEU.projectsummary.0406.xls manage 25.5 K 22 Apr 2006 - 20:56 QingxiaChen  
bmt.csvcsv bmt.csv manage 7.9 K 01 Nov 2012 - 09:48 HuiNian  
cancer.csvcsv cancer.csv manage 1.2 K 26 Sep 2012 - 10:23 HuiNian  
dialysis.txttxt dialysis.txt manage 1.2 K 26 Sep 2012 - 10:22 HuiNian  
leukemia.csvcsv leukemia.csv manage 0.6 K 10 Oct 2012 - 10:32 HuiNian  
tonguecancer.csvcsv tonguecancer.csv manage 2.9 K 19 Sep 2012 - 09:40 HuiNian  
tonguecancer1.csvcsv tonguecancer1.csv manage 2.1 K 29 Aug 2012 - 08:56 HuiNian  
Topic revision: r218 - 09 Nov 2022, QingxiaChen

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