Biostatistics Weekly Seminar

Counting viruses: Estimating the size of the latent HIV reservoir

Michael Hudgens, PhD, Professor of Biostatistics
UNC CFAR Biostatistics Core Director, University of North Carolina

We will discuss statistical methods for quantifying the latent HIV reservoir in anti-retroviral therapy (ART) suppressed individuals. In particular, we will focus on the quantitative virus outgrowth assay (QVOA), a type of serial limiting dilution assay which is used to estimate the number of infectious units per million (IUPM) resting CD4+ T cells. A simple, free publicly available R software package and web tool to analyze serial limiting dilution assay data will be described. We will also consider methods for quantifying the size of the reservoir when additional viral RNA sequence data is available.

MRBIII, Room 1220
1 May 2019

Speaker Itinerary

Topic revision: r4 - 08 Apr 2019, SrKrueger

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