Massion/Jamshed Preinvasive Study

• Start Date: 14 Apr 2004 (Continuation)
• Research Drive Directory: /Massion/040415
  • preinvasive data set (avg_log10.xls) in in /working/preinvasive, the data has been averaged and log10 transformed.
  • the group definition file (groupDef.xls) is in /master.
• Data Type: MassSpec
• Notes:
• Status:
  • Preinvasive Comparison:
  • Kiyoshi and preinvasive Comparison:

Analysis Requests

• 1 Kiyoshi as training
  • Kiyoshi normal vs tumor as training, use to discriminate normal bronchus, Preinvasive LG, HG and invasive tumors
• 3 Preinvasive training testing (average data set)
  • Normal alveolar + normal bronchial VS invasive tumor as training, use to discriminate LG preinvasive and HG.
• 4 Preinvasive intergroup testing (average data set)
  • g1 - A+B vs LG (normal vs preLG)
  • g2 - A+B vs HG (normal vs preHG)
  • g3 - LG vs HG (preLG vs preHG)
  • g4 - LG vs T (preLG vs invasive)
  • g5 - HG vs T (preHG vs invasive)
  • g6 - A+B+LG vs HG+T (Normal preLG vs preHG Invasive)
  • g7 - B vs LG+HG+TS (bronchial vs LG HG SQ)
• 5 (2004-12-08) Cutoff analysis. wilcox P<0.0005, Fisher P<0.0005, perm t-test P<0.0005, sam > 2, WGA > 2, info = 0
  • Kiyoish as training: A, B, HG, LG and T
• 6 (2004-12-08) Cutoff analysis. wilcox P<0.0005, Fisher P<0.0005, perm t-test P<0.0005, sam > 2, WGA > 2, info = 0
  • Preinvasive intergroup testing: A+B vs T as training. HG LG as testing.

Change Log:

• Previous changes to preinvasive.
  • D5, D6 change from #28LUL to #28LUL-D
  • T18, T19 changed from #63 to #63a
  • T32, T33 changed from #63 to #63b
  • B27, B28 removed

• 14 Apr 2004: Data resubmitted with the following changes:
  • Preinvasive: WF16126 changed from HG to LG.
  • Kiyoshi: 8 tumor metastases samples removed

Contact Info:

• Primary Study Contact Person: Jamshedur Rahman

Analysts

• JeremyRoberts
• JoanZhang