Biostatistics Weekly Seminar


Pooling Data from Individual Clinical Trials in the COVID-19 Era

Andrea B. Troxel, ScD
Director, Division of Biostatistics
Professor, Department of Population Health
NYU Grossman School of Medicine

I will discuss a project begun during the COVID-19 pandemic, Continuous Monitoring of Pooled International Trials of Convalescent Plasma for COVID-19 Hospitalized Patients (COMPILE). COMPILE consisted of a secure central repository for pooled data from eight randomized trials of convalescent plasma for the treatment of COVID-19 in hospitalized patients who were not yet on mechanical ventilation; these trials originated from four continents around the globe. A data sharing agreement governed publications and other aspects of the pooling. A secure central data repository hosted deidentified individual patient data and a collective data and safety monitoring board (cDSMB) regularly monitored the accumulating evidence. The pooled dataset was continuously updated with new data at two-week intervals. Unblinded biostatisticians conducted the interim analyses and reported to the cDSMB. I will discuss the details of both the statistical models for the primary outcomes and the decision rules that the collective DSMB used to make recommendations. I will also describe a treatment benefit index developed to predict which patients might benefit most from convalescent plasma therapy.


Virtual: Zoom Link to Follow
27 March 2024
1:30pm


Speaker Itinerary

Topic revision: r1 - 12 Feb 2024, CierraStreeter
 

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