---+ <nop>%TOPIC% ---+++ %BLUE%Guanhua Chen%ENDCOLOR%, <nop>DrPH <verbatim> Vanderbilt University School of Medicine Department of Biostatistics 2525 West End Avenue, Suite 11000 Nashville, TN 37203-1738 james.c.slaughter at vanderbilt.edu</verbatim> Phone: 615.322.0439 | <img width="150" alt="ChrisSlaughter.JPG" src="%ATTACHURLPATH%/Slaughter_JamesChris.jpg" height="210" /> | ---++ Research Interests * Longitudinal data analysis for observational studies * Latent variable methods * Bayesian statistics * Reproductive health applications ---++ Education * *DrPH in Biostatistics* 2007 * University of North Carolina at Chapel Hill * Dissertation: Bayesian Latent Variable Methods for Fetal Growth and Development * Advisor: Amy H Herring * *MS in Biostatistics* 2000 * University of Washington * Advisor: Thomas Lumley * *BS in Cell and Molecular Biology* 1998 * *BS in Mathematics* 1998 * Tulane University ---++ Work Experience * *Assistant Professor* 2007-Present * Vanderbilt University, Department of Biostatistics * *Research Scientist* 2000-2002 * UW-EPA NW Research Center for Particulate Matter and Health * [[%ATTACHURL%/cv.pdf][Curriculum Vitae]] ---++ Courses Taught * [[Epi323Data][Epi 323]]: Design and Analysis with Time to Event Data (Spring 2014) * [[CourseBios312][Bios 312]]: Modern Regression Analysis (Spring 2010-2013) * [[StatBiomedRes][IGP 304]]: Statistics for Biomedical Research (Spring 2008-2009) * [[ClinStat][Statistical Thinking in Biomedical Research]] (2007-2011) ---++ Vanderbilt Collaborations * Gastroenterology * Neonatology * Vaccine Center ---++ Published Papers 1 Vucovich M, Cotton R, Shelton E, Goettel J, Ehinger N, Poole S, Brown N, Wynn J, Paria B, *Slaughter JC*, Clark R, Rojas M, Reese J (2014). _Aminoglycside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA_. American Journal of Physiology - Heart and Circulatory Physiology. Accepted. PMID: 24993047 1 Chorna O, Solomon JE, *Slaughter JC*, Stark AR, Maitre NL. Abnormal sensory reactivity in preterm infants during the first year correlates with adverse neurodevelopmental outcomes at 2 years of age (2014). Archives of Disease in Childhood. 2014 Jul 22[ Epub ahead of print]. PMID: 25053637 1 Maitre NL, *Slaughter JC*, Aschner JL, Key AP (2014). _Hemisphere Differences in Speech-Sound Event-Related Potentials in Intensive Care Neonates: Associations and Predictive Value for Development in Infancy_. Journal of Child Neurology. 2013 Jul 17. [Epub ahead of print]. PMID: 23864588 1 Stouch AN, Zaynagetdinov R, Barham WJ, Stinnett AM, *Slaughter JC*, Yull FE, Hoffman HM, Blackwell TS, Prince LS. _IKK-beta Activity Drives Fetal Lung Macrophage Maturation Along a Non-M1/M2 Paradigm_. The Journal of Immunology (2014) Aug 1;193(3):1184-93. PMID 24981452. 1 Maitre N, Henderson G, Gogliotti S, Pearson J, Simmons A, Wang L, *Slaughter JC*, Key, A. _Feasibility of ERP methodology to evaluate changes in cortical processing after rehabilitation in children with cerebral palsy: a pilot study_. Journal of Clinical and Experimental Neuropsychology 2014 Jun 23:1-11. PMID: 24953907 1 Romano-Keeler J, Moore DJ, Wang C, Brucker RM, Fonnesbeck C, *Slaughter JC*, Li H, Curran DP, Meng S, Correa H, Lovvorn HN 3rd, Tang YW, Bordenstein S, George AL Jr, Weitkamp JH. (2014). _Early life establishment of site-specific microbial communities in the gut._. Gut Microbes. 2014 Mar 1;5(2):192-201. doi: 10.4161/gmic.28442. PMID: 24637795. 1 Maitre NL, *Slaughter JC*, Stark AR, Aschner JL, Anderson AW (2014). _Validation of a brain MRI relaxometry protocol to measure effects of preterm birth at a flexible postnatal age._ BMC Pediatrics. 14:84. doi:10.1186/1471-2431-14-84. PMID: 24678975 1 Bates JT, Keefer C, *Slaughter JC*, Kulp D, Schief W, Crowe JE (2014) _Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein_. Virology. 2014 Apr;454-455:139-44. PMID: 24725940 1 Chorna O, *Slaughter JC*, Wang L, Stark A, Maitre, NL (2014). _A Pacifier-Activated Music Player with mother’s voice improves oral feeding in preterm infants_ Pediatrics. 2014 Mar;133(3):462-8. PMID: 24534413. 1 Coburn LA, Horst SN, Chaturvedi R, Brown CT , Allaman MM, Scull BP, Singh K, Piazuelo MB, Chitnavis MV, Hodges ME, Rosen MJ, Williams CM, *Slaughter JC*, Beaulieu DB, Schwartz DA, Wilson KT (2013). _High-throughput multi-analyte Luminex profiling implicates eotaxin-1 in ulcerative colitis._ PLOS ONE. 2013 Dec 18;8(12):e82300. PMID: 24367513 1 Casner M, Hoesli SJ, *Slaughter JC*, Hill M, Weitkamp JH (2014). _Incidence of Catheter Related Bloodstream Infections in Neonates Following Removal of Peripherally Inserted Central Venous Catheters_. Pediatric Critical Care Medicine. 2014 Jan;15(1):42-8. doi: 10.1097/PCC.0b013e31829f5feb. PMID: 24141656 1 Yachimski P, Shi C, *Slaughter JC*, Washington MK (2013). _Endoscopic mucosal resection of Barrett's esophagus detects high prevalence of subsquamous intestinal metaplasia_. World Journal of Gastrointestinal Endoscopy. 2013 Dec 16;5(12):590-4. PMID: 24368934 1 Coggins SA, Wynn JL, Hill ML, *Slaughter JC*, Ozdas-Weitkamp A, Jalloh O, Waitman LR, Carnevale RJ, Weitkamp JH (2013). _Use of a computerized C-reactive protein (CRP) based sepsis evaluation in very low birth weight (VLBW) infants: A five-year experience_. PLOS ONE. 2013 Nov 11;8(11):e78602. PMID: 24244325. 1 Maitre NL, Smolinsky C, *Slaughter JC*, Stark AR. (2013). _Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures_. Journal of Perinatology. 2013 Nov;33(11):841-6. PMID: 24051577 1 Matire NL, *Slaughter JC*, Aschner JL (2013). _Early prediction of cerebral palsy after neonatal intensive care using motor development trajectories in infancy._ Early Human Development. 2013 Oct;89(10):781-6. PMID: 23856349 1 Gillam-Krakauer M, Cochran CM, *Slaughter JC*, Polavarapu S, !McElroy SJ, Hernanz-Schulman M, Engelhardt B (2013). _Correlation of abdominal rSO(2) with superior mesenteric artery velocities in preterm infants_. Journal of Perinatology. 2013 Aug;33(8):609-12. PMID: 23392317. 1 Cassani L, Sumner E, *Slaughter JC*, Yachimski P (2013). _Directional distribution of neoplasia in Barrett's esophagus is not influenced by distance from the gastroesophageal junction_. Gastrointestinal Endoscopy. 2013 Jun;77(6):877-82. PMID: 23528657 1 Francis DO, Rymer JA, *Slaughter JC*, Choksi Y, Jiramongkolchai P, Ogbeide E, Tran C, Goutte M, Garrett CG, Hagaman D, Vaezi MF (2013). _High Economic Burden of Caring for Patients With Suspected Extraesophageal Reflux_. American Journal of Gastroenterology. 2013 Jun;108(6):905-11. PMID: 23545710. 1 Rice NT, Hu Y, *Slaughter JC*, Ward RM (2013). _Pelvic Mesh Complications in Women Before and After the 2011 FDA Public Health Notification_. Female Pelvic Medicine & Reconstructive Surgery. 2013 Nov-Dec;19(6):333-8. PMID: 24165446. 1 Wilson AJ, Liu AY, Roland JT, Adebayo OB, Fletcher SA, *Slaughter JC*, Saskowski J, Crispens MA, Jones HW, James S, Fadare O, Khabele D. (2013). TR3 modulates platinum resistance in ovarian cancer. Cancer Research. 2013 Aug 1;73(15):4758-69. PMID: 23720056 1 Martinez-Finley EJ, Chakraborty S, *Slaughter JC*, and Aschner M (2013). Early-life exposure to methylmercury in wildtype and pdr-1/parkin knockout C. elegans. Neurochemical Research. Aug;38(8):1543-52. PMID: 23609499 1 Stefanescu BM, Hetu C, *Slaughter JC*, O'Shea TM, and Shetty AK (2013). A Pilot Study of Biotene !OralBalance Gel for Oral Care in Mechanically Ventilated Preterm Neonates. Contemporary Clinical Trials. Jul;35(2):33-9. PMID: 23608625. 1 Cotton RB, Shah LP, Poole SD, Ehinger NJ, Brown N, Shelton EL, *Slaughter JC*, Baldwin HS, Paria BC, Reese J (2013). Cimetidine-associated patent ductus arteriosus is mediated via a cytochrome P450 mechanism independent of H2 receptor antagonism. Journal of Molecular and Cellular Cardiology. Jun;59:86-94. PMID: 23454087. 1 Yuksel ES, *Slaughter JC*, Mukhtar N, Ochieng M, Sun G, Goutte M, Muddana S, Gaelyn Garrett C, Vaezi MF (2013). _An oropharyngeal pH monitoring device to evaluate patients with chronic laryngitis_. Neurogastroenterology and Motility. May;25(5):e315-23. PMID: 23495894 1 Fike CD, Dikalova A, *Slaughter JC*, Kaplowitz MR, Zhang Y, Aschner JL (2013). _Reactive oxygen species reducing strategies improve pulmonary arterial responses to nitric oxide in piglets with chronic hypoxia-induced pulmonary hypertension_ Antioxidants and Redox Signaling. May 10;18(14):1727-38. PMID: 23244497. 1 Gowda M, Danford JM, Hu Y, *Slaughter JC*, Zimmerman CW, Ward RM (2013). _Clinical findings associated with bladder trabeculations in women_. International Urogynecology Journal. Jul;24(7):1167-71. PMID: 23160872 1 Noto JM, Gaddy JA, Lee JY, Piazuelo MB, Friedman DB, Colvin CDC, Romero-Gallo J, Suarez G, Loh J, *Slaughter JC*, Tan S, Morgan DR, Wilson KT, Bravo LE, Correa P, Cover TL, Amieva MR, Peek RM (2013). _Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans._ Journal of Clinical Investigation. Jan 2;123(1):479-92. PMID: 23257361. 1Kavitt RT, Yuksel ES, *Slaughter JC*, Garrett CG, Hagaman D, Higginbotham T, Vaezi MF (2013). _The Role of Impedance Monitoring in Patients With Extraesophageal Symptoms_. The Laryngoscope. Oct;123(10):2463-8. PMID: 23857711 1 Kavitt RT, Higginbotham T, *Slaughter JC*, Patel D, Yuksel ES, Lominadze Z, Abou-Ismail A, Pasricha T, Garrett CG, Hagaman D, Vaezi MF (2012). _Symptom reports are not reliable during ambulatory reflux monitoring._ Am J Gastroenterol. Dec;107(12):1826-32. PMID: 23090349. 1 Yuksel ES, Higginbotham T, *Slaughter JC*, Mabary J, Kavitt R, Garrett CG, Vaezi MF (2012). _Use of direct endoscopic guided mucosal impedance measurement as a novel technique to diagnose GERD._ Clinical Gastroenterology and Hepatology. Dec;107(12):1826-32. PMID: 22642956 1 Chen JX, !OMara PW, Poole SD, Brown N, Ehinger NJ, *Slaughter JC*, Paria BC, Aschner JL, Reese J (2012). _Isoprostanes as physiological mediators of transition to newborn life: Novel mechanisms regulating patency of the term and preterm ductus arteriosus_. Pediatric Research. Aug;72(2):122-8. PMID: 22565502 1 Zhang C, Sherman MP, Prince LS, Bader D, Weitkamp JH, *Slaughter JC*, !McElroy SJ (2012). _Paneth cell ablation in the presence of Klebsiella pneumonia induces necrotizing enterocolitis (NEC) like injury in immature murine small intestine._ Disease Models and Mechanisms. Jul;5(4):522-32. PMID: 22328592. 1 Francis DO, Sumner E, Goutte M, *Slaughter JC*, Garrett CG, Hagaman D, Vaezi M (2012). _Feasibility of dual wireless esophageal pH monitoring: randomized blinded sham-controlled trial._ Otolaryngol Head Neck Surg. Jul;147(1):91-7. PMID: 2236804 1 Saritas Yuksel E, Hong SK, Strugala V, *Slaughter JC*, Goutte M, Garrett CG, Dettmar PW, Vaezi MF. (2012). _Rapid Salivary Pepsin Test: Blinded Assessment of Test Performance in GERD_. The Laryngoscope. Jun;122(6):1312-6. PMID: 22447277. 1 Gold KP, Ward RM, Zimmerman CW, Biller DH, !McGuinn S, *Slaughter JC*, Dmochowski RR. (2011). _Factors Associated With Exposure of Transvaginally-placed Polypropylene Mesh for Pelvic Organ Prolapse._ International Urogynecology Journal. Oct;23(10):1461-6. PMID: 22447037. 1 Fletcher KC, Goutte M, *Slaughter JC*, Garrett CG, Vaezi MF (2011). _Significance and degree of reflux in patients with primary extraesophageal symptoms._ Laryngoscope. Dec;121(12):2561-5. PMID: 22109753 1 !McElroy SJ, Prince LS, Weitkamp JH, Reese J, *Slaughter JC*, Polk DB. (2011). _Tumor Necrosis Factor Receptor 1-Dependent Depletion of Mucus in Immature Small Intestine: A Potential Role in Neonatal Necrotizing Enterocolitis_. AJP Gastrointestinal and Livery Physiology. Oct;301(4):G656-66. PMID: 21737776 1 *Slaughter JC*, Goutte M, Rymer JA, Oranu AC, Schneider JA, Garrett CG, Hagaman D, Vaezi MF (2011). _Caution about Over-Interpretation of Symptom Indices in Reflux Monitoring for Refractory Gastroesophageal Reflux Disease_. Clinical Gastroenterology and Hepatology. Oct;9(10):868-74. PMID: 21782769 1 Francis DO, Goutte M, *Slaughter JC*, Garrett CG, Hagaman D, Holzman MD, Vaezi MF (2011). _Traditional reflux parameters and not impedance monitoring predict outcome post fundoplication in extra-esophageal reflux_ Laryngoscope. Sep;121(9):1902-9. PMID: 22024842. 1 Fike CD, Aschner JL, *Slaughter JC*, Kaplowitz MR, Zhang Y, Pfister SL (2011). _Pulmonary arterial responses to reactive oxygen species are altered in newborn piglets with chronic hypoxia-induced pulmonary hypertension_ Pediatric Research. Aug;70(2):136-41. PMID: 21516056 1 Nagy TA, Allen SS, Wroblewski LE, Flaherty DK, *Slaughter JC*, Perez-Perez G, Israel DA, Peek RM (2011). _Helicobacter pylori induction of eosinophil migration is mediated by the cag pathogenicity island via microbial-epithelial interactions._ American Journal of Pathology. Apr;178(4):1448-52. PMID:21406172 1 Vaezi MF, Hagaman DD, *Slaughter JC*, Tanner SB, Duncavage JA, Allocco CT, Sparkman C, Clement LE, Wasden CM, Wirth D, Goutte M, <nop>McCafferty BA, Lanza DC (2010). _Proton Pump Inhibitor Therapy Improves Symptoms in Post Nasal Drainage._ Gastroenterology. 39(6):1887-1893. PMID: 20801120 1 Fike CD, Pfister S, *Slaughter JC*, Kaplowitz M, Zhang Y, Zeng H, Frye N, Aschner JL (2010). _Protein Complex Formation with Heat Shock Protein 90 (Hsp90) in Chronic Hypoxia-Induced Pulmonary Hypertension in Newborn Piglets_. American Journal of Physiology, Heart and Circulatory Physiology. 299: 1190-1204. PMID: 20693398 1 Vaezi MF, *Slaughter JC*, Smith BS, Washington MK, Jerome WG, Garret CG, Hagaman D, Goutte M (2010). _Dilated Intercellular Space does not Discriminate Controls from Gastroesophageal Reflux Disease or Chronic Laryngitis_. Alimentary Pharmacology & Therapeutics. 32 (7) 916-924. PMID: 20735783 1 Maitre NL, Marshall DD, Goldstein RF, *Slaughter JC*, Price WA. (2010). _Necrotizing enterocolitis in infants with periventricular hemorrhagic infarction: associations and outcomes_. Neonatology. 99(2):97-103 PMID: 20664299 1 Hill ML, Baldwin L, *Slaughter JC*, Walsh WF, Weitkamp J-H (2010). _A Silver Alginate-Coated Dressing to Reduce Peripherally Inserted Central Catheter (PICC) Infections in NICU Patients - a Pilot Randomized Controlled Trial._ The Journal of Perinatology. Jul;30(7):469-73. PMID: 20010613 1 Hong SS, Maltz BE, Coburn LA, *Slaughter JC*, Chaturvedi R, Schwartz DA, Wilson KT (2010). _Increased Serum Levels of L-Arginine in Ulcerative Colitis and Correlation with Disease Severity_ Inflammatory Bowel Disease. 16(1): 105-111. PMCID: PMC2795785 1 Brown N, Morrow JD, *Slaughter JC*, Paria BC, Reese J (2009). _Restoration of on-time embryo implantation corrects the timing of parturition in cytosolic phospholipase A2 group IVA deficient mice._ Biology of Reproduction. 81 (6): 1131-1138. PMID: 19684335 1 Maitre NL, Marshall DD, Price W, *Slaughter JC*, O’Shea TM, Goldstein R (2009). _Neurodevelopmental outcomes of infants with unilateral or bilateral periventricular hemorrhagic infarction._ Pediatrics. 124(6): E1153-E1160. PMID: 19948617 1 *Slaughter JC*, Herring AH, and Thorp JM (2009). _A Bayesian Latent Variable Mixture Model for Longitudinal Fetal Growth._ Biometrics. 65(4) 1233-1242. PMID: 19432784 1 Pritchett JM, Aslam M, *Slaughter JC*, Ness RM, Garrett CG, Vaezi MF (2009). _Efficacy of Esophageal Impedance/pH Monitoring in Patients With Refractory Gastroesophageal Reflux Disease, on and off Therapy._ Clinical Gastroenterology and Hepatology. 7(7): 743-748. PMID: 19281866 1 Sun G, Muddana S, *Slaughter JC*, Vaezi MF (2009). _A New pH Catheter for Laryngopharyngeal Reflux: Normal Values._ The Laryngoscope. 119(8) 1639-1643. PMID: 19504553 1 Hartmann KE, </nop>McPheeters ML, Biller DH, Ward RM, </nop>McKoy JN, Jerome RN, Micucci SR, Meints L, Fisher JA, Scott T, *Slaughter JC*, Blume JD (2009). _Treatment of Overactive Bladder in Women._ Evidence Report/Technology Assessment No. 187 (Prepared by the Vanderbilt Evidence-based Practice Center under Contract No. 290-2007-10065-I.) AHRQ Publication No. 09-E017. Rockville, MD: Agency for Healthcare Research and Quality. August. 2009. PMID: 19947666 1 Johnson JL, Muller KE, *Slaughter JC*, Gurka MJ, Gribbin MJ, Simpson SL (2009). _POWERLIB: SAS/IML Software for Computing Power in Multivariate Linear Models_ Journal of Statistical Software. 30(5), 1-27. 1 Falcone MT, Garrett CG, *Slaughter JC*, Vaezi M (2009). _Transnasal esophagoscopy findings: Interspecialty comparion_. Otolaryngology-Head and Neck Surgery. 140(6): 812-815. PMID: 19467395 1 Aschner JL, Zeng H, Kaplowitz MR, Zhang Y, *Slaughter JC*, Fike CD (2009). _Heat shock protein 90 (Hsp90)/eNOS interactions mature with postnatal age in the pulmonary circulation of the piglet._ Am J Physiol Lung Cell Mol Physiol. 296(3), 555-564. PMCID: PMC2660212 1 Fike CD, *Slaughter JC*, Kaplowitz MR, Zhang Y, and Aschner JL (2008). _Reactive oxygen species from NADPH oxidase contribute to altered pulmonary vascular responses in newborn piglets with chronic hypoxia-induced pulmonary hypertension. Lung, Cellular, and Molecular Physiology._ 295(5), 881-888. PMCID: PMC2584882 1 *Slaughter JC*, Herring AH, and Hartmann KE (2008). _Bayesian Modeling of Embryonic Growth Using Latent Variables._ Biostatistics, 9(2), 373-89. PMID: 18056115 1 Schildcrout JS, Sheppard L, Lumley TS, *Slaughter JC*, Koenig JQ, Shapiro GG (2006). _Ambient air pollution and asthma aggravation in children: An eight-city analysis._ American Journal of Epidemiology, 164(6), 505-517. 1 Sheppard L, *Slaughter JC*, Schildcrout J, Liu S, and Lumley T (2005). _Exposure and Measurement Contributions to Estimates of Acute Air Pollution Effects._ Journal of Exposure Analysis and Environmental Epidemiology, 15, 366-376. 1 *Slaughter JC*, Kim E, Sheppard L, Sullivan JH, Larson TV, Claiborn C (2005). _Association between particulate matter and emergency room visits, hospital admissions, and mortality in Spokane, Washington._ Journal of Exposure Analysis and Environmental Epidemiology, 15, 153-159. 1 *Slaughter JC*, Koenig JQ, Reinhardt TL (Jan 2004). _Association between Lung Function and Exposure to Smoke among Firefighters at Prescribed Burns._ Journal of Occupational and Environmental Hygiene, 1(1), 45-49. 1 *Slaughter JC*, Lumley T, Sheppard L, Koenig JQ, and Shapiro GG (Oct 2003). _Effects of Ambient Air Pollution on Symptom Severity and Medication Usage in Children with Asthma._ Annals of Allergy, Asthma, and Immunology, 91(4), 346-353. 1 Kim E, Larson TV, Hopke PK, *Slaughter C*, Sheppard LE, and Claiborn C (2003). _Source Identification of PM2.5 in an Arid Northwest U.S. City by Positive Matrix Factorization._ Atmospheric Research, 66, 291-305. 1 Liu L-JS, *Slaughter JC*, Larson TV (2002). _Comparison of Light Scattering Devices and Impactors for Particulate Measurements in Indoor, Outdoor, and Personal Environments._ Environ Sci Technol, 36, 2977-2986. ---++ Other information * [[ChrisSlaughterFamilyHistory][History of Family Name]] <!-- __Personal Preferences (details in %TWIKIWEB%.TWikiVariables)__ * Default to using raw text editor: * Set TINYMCEPLUGIN_DISABLE = 1 * Horizontal size of text edit box: * Set EDITBOXWIDTH = 70 * Vertical size of text edit box: * Set EDITBOXHEIGHT = 17 * Style of text edit box. =width: 99%= for full window width (default), =width: auto= to disable. * Set EDITBOXSTYLE = width: 99% * Optionally write protect your home page: (set it to your %TWIKIWEB%.WikiName) * Set ALLOWTOPICCHANGE = ChrisSlaughter * Release Edit Default * Set RELEASEEDITLOCKCHECKBOX = checked="checked" __Related topics__ * %TWIKIWEB%.%WIKIPREFSTOPIC% has site-level preferences of %WIKITOOLNAME%. * %WEBPREFSTOPIC% has preferences of the %WIKITOOLNAME%.%WEB% web. * %MAINWEB%.%WIKIUSERSTOPIC% has a list of other TWiki users. --> <!-- * Email: james.c.slaughter@vanderbilt.edu -->
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