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YizeZhao
(13 Feb 2023,
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%HEAD{ NAME="Yize Zhao, !PhD" AFFILIATION="Associate Professor<br>Department of Biostatistics<br>Yale University" TITLE="Heterogeneity Analysis on Multi-state Brain Functional Connectivity and Adolescent Neurocognition" IMAGELINK="https://res.cloudinary.com/ysm/image/upload/f_auto,q_auto:best,c_fill/yms/prod/cf3cfdcb-a30d-4fda-ae37-385f1dc3a0a4" }% Brain functional connectivity or connectome, a unique measure for brain functional organization, provides a great potential to explain the neurobiological underpinning of behavioral profiles. Existing connectome-based analyses highly concentrate on brain activities under a single cognitive state, and fail to consider heterogeneity when attempting to characterize brain-to-behavior relationships. In this work, we study the complex impact of multi-state functional connectivity on behaviors by analyzing the data from a recent landmark brain development and child health study. We propose a nonparametric, Bayesian supervised heterogeneity analysis to uncover neurodevelopmental subtypes with distinct predictive mechanisms. We impose stochastic block structures to identify network-based functional phenotypes and develop a variational expectation–maximization algorithm to facilitate an efficient posterior computation. Through integrating resting-state and task-related functional connectomes, we dissect heterogeneous predictive mechanisms on children’s fluid intelligence from the functional network phenotypes including Fronto-parietal Network and Default Mode Network under different cognitive states. Meanwhile, our method improves the prediction of children’s fluid intelligence compared with existing alternatives and single state analyses. Based on extensive simulations, we further confirm the superior performance of our method on uncovering and predicting brain-to-behavior relationships. %TAIL{DATE="22 February 2023"}% <!-- * Set HEAD = <div class="w3-card-2" id="task" style="max-width:750px; margin-left: 0px;"> <header class="w3-container w3-blue" style="padding:40px"><h1>Biostatistics Weekly Seminar</h1><br><h2 style="color:white;">%TITLE%<br><br>%NAME%<br>%AFFILIATION%</h2></header><div class="w3-container" style="padding:40px"><IMG SRC=%IMAGELINK% align="left" id="mug"/> * Set TAIL = <br><h3>Hybrid: Meeting Room and Zoom Link to Follow<br>%DATE%<br>1:30pm</h3></div></div><br>[[%TOPIC%Itinerary][Speaker Itinerary]] --> <style> .w3-card-2,.w3-example{box-shadow:0 2px 4px 0 rgba(0,0,0,0.16),0 2px 10px 0 rgba(0,0,0,0.12)!important} .w3-blue,.w3-hover-blue:hover{color:#fff!important;background-color:#2196F3!important} .w3-container{padding:0.01em 16px} .foswikiTopic {font-family: 'Open Sans', sans-serif;} /* Removes location hierarchy (usually written in grey text) */ .patternHomePath {display:none;} /* Removes bar with edit and attach buttons and location hierarchy */ .patternTop{display:none;} h1, h2, h3, h4, h5, h6{font-family: 'Montserrat','Open Sans', sans-serif;font-weight:700;} h1, h2, h3, h4, h5, h6{color:#bf1735;} h1:first-of-type{color:#2a3e6e;margin-bottom:25px;margin-top:5px;} .foswikiImage{margin-left:-9px;} img#mug{padding-right: 40px; padding-bottom:25px; height:250px;} </style>
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Topic revision: r1 - 13 Feb 2023,
CierraStreeter
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