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Ya-ChenLisaLin17April2019
(05 Apr 2019,
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%HEAD{ NAME="Ya-Chen Lisa Lin, !PhD Candidate" AFFILIATION="Vanderbilt University" TITLE="Evaluation of relative risk model in PheWAS analysis" IMAGELINK="https://s3.amazonaws.com/vu-wp0/wp-content/uploads/sites/190/2017/11/05144350/B19027FD-CBB1-440D-B26B-B13CA8EA9BB8-e1536167878841.jpeg" }% The Phenome-wide association study (PheWAS) has become widely used for efficient, high-throughput evaluation of relationship between a genetic variation and a large collection of clinical diagnoses, typically extracted from a DNA biobank linked with electronic health records (EHR). The case-control analysis has been the standard choice for its efficiency in rare disease analysis and power to identify risk factors. However the clinical diagnoses in EHR are often inaccurate with errors and may cause bias. In the presentation, I will talk about the basic concepts for PheWAS, the most common type of misclassification in PheWAS and current solution to the issue. I will evaluate how well different method perform with the varying degree of the issues. %TAIL{DATE="17 April 2019"}% <!-- * Set HEAD = <div class="w3-card-2" id="task" style="max-width:750px; margin-left: 0px;"> <header class="w3-container w3-blue" style="padding:40px"><h1>Biostatistics Weekly Seminar</h1><br><h2 style="color:white;">%TITLE%<br><br>%NAME%<br>%AFFILIATION%</h2></header><div class="w3-container" style="padding:40px"><IMG SRC=%IMAGELINK% align="left" id="mug"/> * Set TAIL = <br><h3>MRBIII, Room 1220<br>%DATE%<br>1:30pm</h3></div></div><br>[[%TOPIC%Itinerary][Speaker Itinerary]] --> <style> .w3-card-2,.w3-example{box-shadow:0 2px 4px 0 rgba(0,0,0,0.16),0 2px 10px 0 rgba(0,0,0,0.12)!important} .w3-blue,.w3-hover-blue:hover{color:#fff!important;background-color:#2196F3!important} .w3-container{padding:0.01em 16px} .foswikiTopic {font-family: 'Open Sans', sans-serif;} /* Removes location hierarchy (usually written in grey text) */ .patternHomePath {display:none;} /* Removes bar with edit and attach buttons and location hierarchy */ .patternTop{display:none;} h1, h2, h3, h4, h5, h6{font-family: 'Montserrat','Open Sans', sans-serif;font-weight:700;} h1, h2, h3, h4, h5, h6{color:#bf1735;} h1:first-of-type{color:#2a3e6e;margin-bottom:25px;margin-top:5px;} .foswikiImage{margin-left:-9px;} img#mug{padding-right: 40px; padding-bottom:25px; height:250px;} </style>
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Topic revision: r4 - 05 Apr 2019,
SrKrueger
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