Surgery, anesthesiology, and emergency and critical care medicine
The Biostatistics Clinic on Wednesdays is dedicated to biostatistics applications in surgery, anesthesiology, and emergency and critical care medicine.
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2022,
2021,
2020,
2019,
2018,
2017,
2016,
2015,
2014, and
before.
Current Notes (2023)
2023 January 11
Melanie Hicks (Michael Topf), Otolaryngology
We are developing a RCT evaluating the SNRI Venlafaxine in patients undergoing surgical treatment for head and neck cancer. Our primary endpoints are rate of depression, anxiety, and uncontrolled pain at the end of 3 months. Mentor confirmed.
- Meeting Notes
- Primary outcome: Dichotomize depression based on PHQ-9 score
- Subjects with a PHQ-9 score 0-9, randomized to placebo or drug
- PHQ-9 score collected again 4 months later to determine if they developed depression
- Recommendations
- Recommended to apply for a VICTR voucher
Destini Long (Courtney Sutton), Pharmacy
Retrospective chart review of neonates in the NICU who recorded either Levetiracetam or Phenobarbital first-line for seizures. Accessing weather levetiracetam is equally as effective as phenobarbital in stopping seizures. Need to address which functions and tests (student t-test, chi-square, fisher exact, etc) are needed to correctly analyze my data in SPS. Mentor confirmed.
- Meeting Notes
- Data: collected retrospectively from VUMC over a 2-year period
- N = 87
- Includes neonates alive for 0-60 days given at least one of the 2 drugs, and have had seizure activity
- Primary outcome: seizure resolution (yes/no)
- Recommendations
- For binary outcomes (ex: seizure resolution), can use a chi-square test
- Start with a 2x2 table to determine cell count sizes
- If any cells are <5, use a Fisher’s exact test
- For continuous outcomes, can use a Wilcoxon rank sum tests
- For seizure resolution after switching drugs, display this with summaries as a descriptive statistic
- If the bandwidth is there, consider regression models (logistic regression for binary outcome)
- Could include covariates (maybe just one or two with small sample size)
2023 January 18
Bo Stubblefield, Emergency Medicine
Evaluation of a prospective identification system of patients with acute pulmonary embolism in the emergency department. NLP applied to radiology reports in ED patients. Help with analysis in generating ROC curve.
2023 January 25
Shreyas Krishnapura (Michael Topf), Otolaryngology
This study involved creating one-page treatment summary documents for Head and Neck cancer patients that are in remission after undergoing definitive therapy. Patients are surveyed on their knowledge of their cancer history before providing the summary and one month after. Data collection has been completed. Need to address which functions and tests (Wilcoxan-sign-ring, Mcnemars etc) are needed to correctly analyze the data. Mentor confirmed. VICTR Biostatistics voucher.