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ValerieWelty20Novemeber2019
(18 Nov 2019,
TawannaPeters
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%HEAD{ NAME="Valerie Welty" AFFILIATION="Vanderbilt University School of Medicine" TITLE="Introduction to False Discovery Rates in Large-Scale Inference" IMAGELINK="https://cdn.vanderbilt.edu/vu-wp0/wp-content/uploads/sites/190/2017/11/05144948/8C47211D-C86F-449E-9006-96F35B263B78-e1536167775899.jpeg" }% The false discovery rate as defined by Benjamini and Hochberg has become a popular alternative to the family-wise error rate (FWER) in error control when testing a large number of hypotheses (i.e. large-scale inference). The type of false discovery rate (FDR) used by Benjamini and Hochberg is one of several potential FDR definitions studied in the last few decades, with considerable contributions by Storey et al. and Efron et al. Use of these alternative FDRs, such as the positive false discovery rate (pFDR), move the focus from testing algorithms to estimation of FDRs. A variety of non-parametric and parametric Empirical Bayes approaches for estimating probabilistic FDRs based on a large number of observed test statistics have been developed. In this seminar, I will introduce the relevant components of large-scale inference, review the various FDRs, outline the connections between testing procedures and false discovery rate estimation, and briefly introduce several Empirical Bayes approaches for FDR estimation focusing on the methods of Efron et al. . %TAIL{DATE="20 November 2019"}% <!-- * Set HEAD = <div class="w3-card-2" id="task" style="max-width:750px; margin-left: 0px;"> <header class="w3-container w3-blue" style="padding:40px"><h1>Biostatistics Weekly Seminar</h1><br><h2 style="color:white;">%TITLE%<br><br>%NAME%<br>%AFFILIATION%</h2></header><div class="w3-container" style="padding:40px"><IMG SRC=%IMAGELINK% align="left" id="mug"/> * Set TAIL = <br><h3>MRBIII, Room 1220<br>%DATE%<br>1:30pm</h3></div></div><br>[[%TOPIC%Itinerary][Speaker Itinerary]] --> <style> .w3-card-2,.w3-example{box-shadow:0 2px 4px 0 rgba(0,0,0,0.16),0 2px 10px 0 rgba(0,0,0,0.12)!important} .w3-blue,.w3-hover-blue:hover{color:#fff!important;background-color:#2196F3!important} .w3-container{padding:0.01em 16px} .foswikiTopic {font-family: 'Open Sans', sans-serif;} /* Removes location hierarchy (usually written in grey text) */ .patternHomePath {display:none;} /* Removes bar with edit and attach buttons and location hierarchy */ .patternTop{display:none;} h1, h2, h3, h4, h5, h6{font-family: 'Montserrat','Open Sans', sans-serif;font-weight:700;} h1, h2, h3, h4, h5, h6{color:#bf1735;} h1:first-of-type{color:#2a3e6e;margin-bottom:25px;margin-top:5px;} .foswikiImage{margin-left:-9px;} img#mug{padding-right: 40px; padding-bottom:25px; height:250px;} </style>
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Topic revision: r1 - 18 Nov 2019,
TawannaPeters
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