Please provide a short description of your project and the questions you’d like to address: Our group is imaging brown adipose tissue in humans. We would like to design a study to understand the responses of brown adipose tissue, white adipose tissue, muscle, and liver to cold exposure and feeding using MRI. In addition, we would like to study how these responses vary with age, body composition, sex, and physical activity.
VICTR Voucher, Mentor confirmed
Meeting notes: FSF is ratio of fat tissue seen in MRI. The activation of the BAT is usually measured by an average of voxole over certain threshhold . Discussed how best to show change in fsf aong different tissues. Suggested going back to raw data and considering 3d tensor splines. Suggest focusing on inflection points within individuals.
Childhood cancer survivors are known to be at increased risk for cardiovascular disease. As a result, period, serial, cardiac screening is recommended. Currently, cardiac screening focuses on LVEF, a late marker of cardiac dysfunction. My goal is to determine is myocardial strain can be used as an early marker of cardiovascular dysfunction and thereby provide an earlier opportunity of clinical intervention. I would like to determine 1) The prevalence of abnormal strain in early off therapy childhood cancer survivors, 2) the natural history of strain on serial imaging, and 3) the short and long term cardiovascular outcomes associated with abnormal strain.
VICTR Voucher, Mentor confirmed
Walk-in: looking at inflammation leading to physiological changes in organs which causes function changes. Specifically lung function. Interested in which changes such as airways, attachment, thickness
Meeting notes: Discussed regression techniques. Recommended sorting out identifiying which pre-dates which and the pathways involved in the process to assist in mediation analysis.