TDT2locus: A R program for two-locus TDT analysis

The program has two functions. The function readin() is for reading in data from a file and processing data into a format that can be used by the analysis program, TDT2L(). It will be called by TDT2L(). The main analysis program is TDT2L().

The input data file should have one title line and three columns: family ID, gene 1 geneotype, gene 2 genotype. Genotypes should be coded as 0, 1, 2. Missing data should be denoted as a dot. The families should be sorted so that family members are clustered together, with the first two members as the parents and the other members as the offspring. A sample data file looks like this:

family   G1   G2
100501   1   1
100501   0   1
100501   0   1
100501   1   1
100701   0   2
100701   1   1
100701   1   .
100701   0   1
200601   0   1
200601   0   1
200601   0   1
1001201   .   1
1001201   .   2
1001201   .   1
1001201   .   2
1001501   1   0
1001501   1   0
1001501   1   0
1001801   1   0
1001801   0   2
1001801   1   1
1001801   1   1