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RobertGreevy20211110
(03 Nov 2021,
SimonVandekar
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%HEAD{ NAME="Robert Greevy, !PhD" AFFILIATION="VUMC" TITLE="Rescuing Randomized Trials: How to Detect and Correct Unlucky Randomizations as They Occur" IMAGELINK="https://www.vumc.org/biostatistics/sites/default/files/people/thumbnail_Greevy-headshot2%20%281%29.jpg" }% A fundamental misconception of randomized trials is that randomization prevents selection bias. However, it is not uncommon to see multimillion dollar randomized trials with clinically meaningful differences in baseline covariates between treatment arms. Trials that have had an “unlucky” randomization provide a lower quality of evidence. As we monitor trials for adverse events and deviations from protocol, we should monitor trials for unlucky randomizations. This talk will present our team’s experience of monitoring randomization quality in a randomized trial using REDCap, encountering an unlucky randomization, and the remedy adopted. The majority of this talk will be accessible to a broad clinical audience. %TAIL{DATE="10 November 2021"}% <!-- * Set HEAD = <div class="w3-card-2" id="task" style="max-width:750px; margin-left: 0px;"> <header class="w3-container w3-blue" style="padding:40px"><h1>Biostatistics Weekly Seminar</h1><br><h2 style="color:white;">%TITLE%<br><br>%NAME%<br>%AFFILIATION%</h2></header><div class="w3-container" style="padding:40px"><IMG SRC=%IMAGELINK% align="left" id="mug"/> * Set TAIL = <br><h3>Zoom (Link to Follow)<br>%DATE%<br>1:30pm</h3></div></div><br> --> <style> .w3-card-2,.w3-example{box-shadow:0 2px 4px 0 rgba(0,0,0,0.16),0 2px 10px 0 rgba(0,0,0,0.12)!important} .w3-blue,.w3-hover-blue:hover{color:#fff!important;background-color:#2196F3!important} .w3-container{padding:0.01em 16px} .foswikiTopic {font-family: 'Open Sans', sans-serif;} /* Removes location hierarchy (usually written in grey text) */ .patternHomePath {display:none;} /* Removes bar with edit and attach buttons and location hierarchy */ .patternTop{display:none;} h1, h2, h3, h4, h5, h6{font-family: 'Montserrat','Open Sans', sans-serif;font-weight:700;} h1, h2, h3, h4, h5, h6{color:#bf1735;} h1:first-of-type{color:#2a3e6e;margin-bottom:25px;margin-top:5px;} .foswikiImage{margin-left:-9px;} img#mug{padding-right: 40px; padding-bottom:25px; height:250px;} </style>
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Topic revision: r2 - 03 Nov 2021,
SimonVandekar
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