You are here:
Vanderbilt Biostatistics Wiki
>
Main Web
>
Seminars
>
WednesdaySeminarSeries
>
RanTao20200115
(13 Jan 2020,
AndrewSpieker
)
(raw view)
E
dit
A
ttach
%HEAD{ NAME="Ran Tao, !PhD" AFFILIATION="Vanderbilt University Medical Center" TITLE="Optimal Designs of Two-Phase Studies" IMAGELINK="https://www.vumc.org/biostatistics/sites/default/files/people/RanTao.jpg" }% The two-phase design is a cost-effective sampling strategy to evaluate the effects of covariates on an outcome when certain covariates are too expensive to be measured on all study subjects. Under such a design, the outcome and inexpensive covariates are measured on all subjects in the first phase and the first-phase information is used to select subjects for measurements of expensive covariates in the second phase. Previous research on two-phase studies has focused largely on the inference procedures rather than the design aspects. We investigate the design efficiency of the two-phase study, as measured by the semiparametric efficiency bound for estimating the regression coefficients of expensive covariates. We consider general two-phase studies, where the outcome variable can be continuous, discrete, or censored, and the second-phase sampling can depend on the first-phase data in any manner. We develop optimal or approximately optimal two-phase designs, which can be substantially more efficient than the existing designs. We demonstrate the improvements of the new designs over the existing ones through extensive simulation studies and two large medical studies. %TAIL{DATE="15 January 2020"}% <!-- * Set HEAD = <div class="w3-card-2" id="task" style="max-width:750px; margin-left: 0px;"> <header class="w3-container w3-blue" style="padding:40px"><h1>Biostatistics Weekly Seminar</h1><br><h2 style="color:white;">%TITLE%<br><br>%NAME%<br>%AFFILIATION%</h2></header><div class="w3-container" style="padding:40px"><IMG SRC=%IMAGELINK% align="left" id="mug"/> * Set TAIL = <br><h3>MRBIII, Room 1220<br>%DATE%<br>1:30pm</h3></div></div><br> --> <style> .w3-card-2,.w3-example{box-shadow:0 2px 4px 0 rgba(0,0,0,0.16),0 2px 10px 0 rgba(0,0,0,0.12)!important} .w3-blue,.w3-hover-blue:hover{color:#fff!important;background-color:#2196F3!important} .w3-container{padding:0.01em 16px} .foswikiTopic {font-family: 'Open Sans', sans-serif;} /* Removes location hierarchy (usually written in grey text) */ .patternHomePath {display:none;} /* Removes bar with edit and attach buttons and location hierarchy */ .patternTop{display:none;} h1, h2, h3, h4, h5, h6{font-family: 'Montserrat','Open Sans', sans-serif;font-weight:700;} h1, h2, h3, h4, h5, h6{color:#bf1735;} h1:first-of-type{color:#2a3e6e;margin-bottom:25px;margin-top:5px;} .foswikiImage{margin-left:-9px;} img#mug{padding-right: 40px; padding-bottom:25px; height:250px;} </style>
E
dit
|
A
ttach
|
P
rint version
|
H
istory
: r1
|
B
acklinks
|
V
iew topic
|
Edit
w
iki text
|
M
ore topic actions
Topic revision: r1 - 13 Jan 2020,
AndrewSpieker
Main
Department Home Page
Biostatistics Graduate Program
Vanderbilt University Medical Center
Main Web
Main Web Home
Search
Recent Changes
Changes
Topic list
Biostatistics Webs
Archive
Main
Sandbox
System
Register
|
Log In
Copyright © 2013-2022 by the contributing authors. All material on this collaboration platform is the property of the contributing authors.
Ideas, requests, problems regarding Vanderbilt Biostatistics Wiki?
Send feedback