(r11) ProjectsOfMichaelMatheny < Main < Vanderbilt Biostatistics Wiki

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-- Main.SvetlanaEden - 09 Nov 2010
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---+ Population Definitions
---++++Population One
   1 Inpatient Scr greater than 2 (!InptCrCtr > 2)
   1 Non-missing baseline Scr (!MostRecentPreadmitOutptCr - non-missing)
   1 !DaysFirstEncounterPostDC <= 365
---++++Population Two
All patients from Population One plus
   1 Days from admission to death is non-negative (!DaysDeathFromAdm>=0)
   1 No preadmission dialysis appointment (!PreAdmitDialysisCtrAppt = 0)
   1 !PreAdmDialysisCtrICD = 0
   1 Most recent outpatient GFR >=15 (!MostRecentOutPtGFR >= 15)
   1 No preadmission renal transplantations (!PreAdmit_RenalTransplant == 0 )
   1 No dialysis post peak 23 to 30 days (!PostPeak_23_30_Dialysis == 0)
   1 Length of stay is 30 days or less (!LOSDays <= 30)
   1 No preadmission renal appointment (!PreAdmitRenalClinicScheduledCtr == 0)
   1 !LastBefore30DayPostPeakGFR < 60
   1 No preadmission renal visit (!PreAdmitRenalClinicSeen == 0)
   1 Non-missing !PreAdmRenalConsultCtr
---++++Analysis Population
All patients from Population Two plus
   1 AKI stage 1 or greater (!AKINStage >=1)
   1 No discharge diagnosis of ESRD within 30 days of admission (missing !Discharge_ESRD_WI30)
   1 Not a preadmission hospice patient (!PreAdmit_Hospice==0) 
   1 First admission (!FirstAKIAdmit = 1)
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---+ Variable Definitions
   * !DaysFirst30DayPostPeakGTE60GFR - the first time after 30 days post peak in which the GFR for the patient was above or equal to 60.
      * take all of the creatinines for each patient after the first 30 days post peak
      * calculated their GFR based on the equation (race, age, gender)
      * filter to keep only those that were 60 or above
      * find the first time (in days after 30 days peak) in which that was the case
   * !RecoveredAfter270Days - if patient's recovery (GFR of 60 or greater) is observed at or after 270 days in the after-30-days-post-peak period.
      * !DaysFirst30DayPostPeakGTE60GFR >= 270
   * !strataBlGFR60, two levels
      * "less than 60" if !MostRecentOutPtGFR<60
      * "60 or more" if !MostRecentOutPtGFR >= 60
   * !HundrPercServConn
      * date of service connection is before admission: !100SCDate < admDate
   * Diagnosis Variables ("CADDx", "CHFDx", "DMDx", "HTNDx", "PVDDx")
      * !CADDx TRUE (a person was diagnosed with CAD) if !CADDxDate was equal or before the admission date (admDate)
   * Variable time-to-dialysis dialysisDays
      * !minimum of !PostPeak30DialysisCtrCD and !PostPeak30DialysisCtrAppt
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---+ Analysis references
   1 Robert J. Gray, A CLASS OF K-SAMPLE TESTS FOR COMPARING THE CUMULATIVE INCIDENCE OF A COMPETING RISK, The Annals of Statistics, 1988, Vol 16, No. 3, 1141-1154
   1 Jason P. Fine, Robert J. Gray, A PROPORTIONAL HAZARD MODEL FOR THE SUBDISTRIBUTION OF A COMPETING RISK, Journal of the American Statistical Association, June 1999, Vol. 94, No. 446, 496-509
   1 Melania Pintilie, COMPETING RISKS, A PRACTICAL PERSPECTIVE, 2006, John Wiley & Sons, Ltd.
   1 Terry M. Therneau, Patricia M. Grambsch, MODELING SURVIVAL DATA, EXTENDING THE COX MODEL, 2000, Springer, New York

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Topic revision: r11 - 24 Jan 2011, SvetlanaEden

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