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SvetlanaEden - 09 Nov 2010
Population Definitions
Population One
- Inpatient Scr greater than 2 (InptCrCtr > 2)
- Non-missing baseline Scr (MostRecentPreadmitOutptCr - non-missing)
- DaysFirstEncounterPostDC <= 365
Population Two
All patients from Population One plus
- Days from admission to death is non-negative (DaysDeathFromAdm>=0)
- No preadmission dialysis appointment (PreAdmitDialysisCtrAppt = 0)
- PreAdmDialysisCtrICD = 0
- Most recent outpatient GFR >=15 (MostRecentOutPtGFR >= 15)
- No preadmission renal transplantations (PreAdmit_RenalTransplant == 0 )
- No dialysis post peak 23 to 30 days (PostPeak_23_30_Dialysis == 0)
- Length of stay is 30 days or less (LOSDays <= 30)
- No preadmission renal appointment (PreAdmitRenalClinicScheduledCtr == 0)
- LastBefore30DayPostPeakGFR < 60
- No preadmission renal visit (PreAdmitRenalClinicSeen == 0)
- Non-missing PreAdmRenalConsultCtr
Analysis Population
All patients from Population Two plus
- AKI stage 1 or greater (AKINStage >=1)
- No discharge diagnosis of ESRD within 30 days of admission (missing Discharge_ESRD_WI30)
- Not a preadmission hospice patient (PreAdmit_Hospice==0)
- First admission (FirstAKIAdmit = 1)
Variable Definitions
- DaysFirst30DayPostPeakGTE60GFR - the first time after 30 days post peak in which the GFR for the patient was above or equal to 60.
- take all of the creatinines for each patient after the first 30 days post peak
- calculated their GFR based on the equation (race, age, gender)
- filter to keep only those that were 60 or above
- find the first time (in days after 30 days peak) in which that was the case
- RecoveredAfter270Days - if patient's recovery (GFR of 60 or greater) is observed at or after 270 days in the after-30-days-post-peak period.
- DaysFirst30DayPostPeakGTE60GFR >= 270
- strataBlGFR60, two levels
- "less than 60" if MostRecentOutPtGFR<60
- "60 or more" if MostRecentOutPtGFR >= 60
- HundrPercServConn
- date of service connection is before admission: 100SCDate < admDate
- Diagnosis Variables ("CADDx", "CHFDx", "DMDx", "HTNDx", "PVDDx")
- CADDx TRUE (a person was diagnosed with CAD) if CADDxDate was equal or before the admission date (admDate)
- Variable time-to-dialysis dialysisDays
- minimum of PostPeak30DialysisCtrCD and PostPeak30DialysisCtrAppt
Analysis references
- Kalbfleisch, J.D. and Prentice, R.L.(1980) The Statistical Analysis of Failure Time Data. New York: John Wiley & Sons, Inc.
- Robert J. Gray, A CLASS OF K-SAMPLE TESTS FOR COMPARING THE CUMULATIVE INCIDENCE OF A COMPETING RISK, The Annals of Statistics, 1988, Vol 16, No. 3, 1141-1154
- Jason P. Fine, Robert J. Gray, A PROPORTIONAL HAZARD MODEL FOR THE SUBDISTRIBUTION OF A COMPETING RISK, Journal of the American Statistical Association, June 1999, Vol. 94, No. 446, 496-509
- Melania Pintilie, COMPETING RISKS, A PRACTICAL PERSPECTIVE, 2006, John Wiley & Sons, Ltd.
- Terry M. Therneau, Patricia M. Grambsch, MODELING SURVIVAL DATA, EXTENDING THE COX MODEL, 2000, Springer, New York