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PatrickHeagerty20210519
(14 May 2021,
AndrewSpieker
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%HEAD{ NAME="Patrick Heagerty, !PhD" AFFILIATION="University of Washington" TITLE="Evidence-based analysis of longitudinal data from randomized clinical trials" IMAGELINK="https://www.biostat.washington.edu/sites/default/files/styles/directory_image/public/2020-03/patrick-heagerty.jpg?itok=-yEIKjRt" }% Prospective randomized longitudinal studies are the foundation for rigorous generation of medical evidence. Increasing focus on patient-reported outcomes and serial measures of health status imply that quantitative outcomes are common primary outcomes in contemporary trials. Frequently the study design and protocol specify the collection of outcomes both at baseline and select follow-up times, with a primary analysis that often considers one key follow-up time. The goal of this talk is to review the statistical evidence that informs the selection of a primary longitudinal analysis strategy. Seminal results of Frison and Pocock (1992) and Yang and Tsiatis (2001) form the basis for leveraging model-assisted inference with repeated measures. We review these fundamental results and generalize to multiple follow-up measures. We emphasize the advantage of using known assumptions such as randomization to enhance precision while not making additional assumptions that can threaten validity of model-based or model-assisted inference. We illustrate ideas using a recently published trial of depression treatment and highlight how existing software can be adopted for evidence-based analysis. %TAIL{DATE="19 May 2021"}% <!-- * Set HEAD = <div class="w3-card-2" id="task" style="max-width:750px; margin-left: 0px;"> <header class="w3-container w3-blue" style="padding:40px"><h1>Biostatistics Weekly Seminar</h1><br><h2 style="color:white;">%TITLE%<br><br>%NAME%<br>%AFFILIATION%</h2></header><div class="w3-container" style="padding:40px"><IMG SRC=%IMAGELINK% align="left" id="mug"/> * Set TAIL = <br><h3>Zoom (Link to Follow)<br>%DATE%<br>1:30pm</h3></div></div><br>[[%TOPIC%Itinerary][Speaker Itinerary]] --> <style> .w3-card-2,.w3-example{box-shadow:0 2px 4px 0 rgba(0,0,0,0.16),0 2px 10px 0 rgba(0,0,0,0.12)!important} .w3-blue,.w3-hover-blue:hover{color:#fff!important;background-color:#2196F3!important} .w3-container{padding:0.01em 16px} .foswikiTopic {font-family: 'Open Sans', sans-serif;} /* Removes location hierarchy (usually written in grey text) */ .patternHomePath {display:none;} /* Removes bar with edit and attach buttons and location hierarchy */ .patternTop{display:none;} h1, h2, h3, h4, h5, h6{font-family: 'Montserrat','Open Sans', sans-serif;font-weight:700;} h1, h2, h3, h4, h5, h6{color:#bf1735;} h1:first-of-type{color:#2a3e6e;margin-bottom:25px;margin-top:5px;} .foswikiImage{margin-left:-9px;} img#mug{padding-right: 40px; padding-bottom:25px; height:250px;} </style>
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Topic revision: r3 - 14 May 2021,
AndrewSpieker
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