Summary of the collaboration plan activities with the Department of Ophthalmology

Chun Li, Ph.D.

Pengcheng Lu, M.S.

Last update: June 11, 2009

From January 2008, Mr. Pengcheng Lu is the master's statistician for Ophthalmology with 30% support. Dr. Li maintains 5% support and will be supervising Pengcheng.

Ongoing Projects

1. Dr. Anita Agarwal (09/2004 -): Genetics of diabetic retinopathy (IRB approved). We are recruiting subjects. Grants submitted: DTRC (Anita, 01/2007, not funded); Discovery (Chun, 03/2007, not funded); R21 (Chun, 06/2007 first submission, 03/2008 resubmission).
2. Dr. Karen Joos (06/2006 -): Pressure change in the eyes of rats as a result of a device. Two measuring tools were used. Manuscripts under preparation (5/2/07)
3. Dr. Rachel Kuchtey (02/2007 -): Candidate gene study on glaucoma.
4. Dr. Paul Sternberg (01/2007 -): I am a statistician (5%) on one of his R01 grants.
5. Dr. Louise Mawn: Analyzing pilot data for her endoscope project
6. Dr. Wright Benjamin Lauten (04/2008-05/2008): We analyzed his data.

Past projects

1. Dr. Jiyang Cai(6/2010): Pengcheng helped with statistical analysis for microarray study.
2. Dr. Jiyang Cai(5/2010): We helped with statistical analysis for SNP study.
3. Drs. Bryan Armstrong/Sachin Metha(5/2010): We helped with statistical analysis for antibiotic (Vancomycin/Ceftazidime/Moxifloxacin) studies.
4. Drs. Michael Dieckhaus/Karen Joos(5-6/2010): Pengcheng helped with statistical graphic.
5. Dr. Rahul Reddy(4/2010): Pengcheng helped with statistical questions.
6. Dr. Rahul Reddy(12/2009): Pengcheng helped with statistical analysis for the ROP study.
7. Dr. Ryan Tarantola(6/2009): We helped with statistical graphic.
8. Dr. Maziar Lalezary Maz(5/2009): Pengcheng analyzed his data for his Resident's Day project.
9. Dr. Wright Lauten(5/2009): Pengcheng helped with questions.
10. Dr. Marc Moore(5/2009): Pengcheng analyzed his updated data for his Resident's Day project.
11. Dr. Desiree Ong(5/2009): Pengcheng analyzed his data for her Resident's Day project.
12. Dr. David Reichstein (5/2009): Pengcheng analyzed his data and helped with questions.
13. Dr. Hassanain Toma(4/2009): We helped with questions.
14. Dr. Jiyang Cai(4/2009): Pengcheng analyzed his data for Retina Congress 2009
15. Dr. Jeffery Colburn(3/2009): Pengcheng analyzed his project data regarding intermitent exotropia for his paper
16. Dr. Jeffery Sonsino(3/2009): Pengcheng helped with questions about his study design
17. Dr. Ryan Tarantola(3/2009): We generated new graphics after changing day cutoff for his study
18. Dr. Jeffery Sonsino(2/2009): Pengcheng did power calculation for his study
19. Dr. Ryan Tarantol(2/2009): We generated graphics for his paper
20. Dr. Ryan Tarantol(12/2008): We analyzed his data
21. Dr. Jiyang Cai(11/2008): Pengcheng did power calculation for Dr. Sternberg's IRB protocol
22. Dr. Rachel Kuchtey (11/2008): I analyzed his data for ARVO abstract and manuscript.
23. Dr. Marc Moore (11/2008): I analyzed his data for ARVO abstract.
24. Dr. Louise Mawn (11/2008): I analyzed his data for ARVO abstract.
25. Dr. Franco Recchia (11/2008): I analyzed his data for ARVO abstract.
26. Dr. David Reichstein (11/2008): Pengcheng analyzed his data for ARVO abstract.
27. Dr. Larry Merin (11/2008): I explained how to use excel to count the number of "X" in a column and how to change a cell's format information.
28. Dr. Wright Lauten(5/2008): We analyzed his data.
29. Dr. Keshini Parbhu (05/2008): We analyzed her data.
30. Dr. Jeffrey Colburn (05/2008): We analyzed his data.
31. Dr. Prat Itharat (05/2008): I explained what can be done in linear regression analysis to evaluate relative contributions of different variables towards explanation of the outcome variable.
32. Dr. Marc Aaron Moore (05/2008): I met with him to explain what can be done for his project involving 16 subjects.
33. Dr. Desiree Ong (05/2008): I explained what types of analysis can be done for his/her project and helped explained the results.
34. Dr. Jeffrey Sonsino (04/2008): We helped with power calculations for his project "Evaluation of Illuminated Low Vision Glasses".
35. Dr. Jiyang Cai (03/2008-04/2008): Pengcheng helped with questions.
36. Dr. John Kuchtey (11/2007): Carry out test of correlation between protein intensity readings and blot intensity readings.
37. Dr. Paul Sternberg and Jiyang Cai (11/2007): Preliminary data analysis using 52 subjects (AMD patients and controls) on 19 variables (14 cytokines).
38. Dr. John and Rachel Kuchtey (10/2007): Power calculation on pig glaucoma protein intensity comparison.
39. Dr. Larry Merin (09/2007): Read his application to Tennessee Center for Diabetes Prevention and Health Improvement.
40. Dr. Ryan Tarantola, Jeffrey Kammer (07/2007): Sample size calculation for their obesity-IOP study.
41. Dr. Louise Mawn (07/2007): Answered questions for her paper revision.
42. Dr. Daniel Bustos (05/2007): I explained how to do analysis on his amiodarone study.
43. Dr. Rehan Ahmed, Larry Merin (05/2007): Read his manuscript on screening VA diabetics, and did some analyses for comparisons.
44. Dr. David Calkins (04/2007-05/2007): E-mails about testing for equal slopes between two groups. I carried out the analysis for David.
45. Drs. Keshini Parbhu, Louise Mawn (12/2006): I did data analysis for their floor fracture study. A paper has been published (Parbhu KC, Galler KE, Li C, Mawn LA. 2008. Ophthalmology (in press) (PMID: 18440640))
46. Dr. Keshini Parbhu (12/2006): We met to discuss her data. I recommend she collect the controls. I analyzed data about periocular trauma in pediatric patients that sustained lacerations to their canalicular system (tear duct).
47. Dr. Korianne Galler (12/2006): Test if entrapment identification of the CT and the operative procedures are concordant or not in adults and in children, respectively, and to see if the discordance in children is statistically significant.
48. Drs. Alejandro Leon, Sean Donahue (09/2006-04/2007): Study of the effects of age and anisometropia on amblyopia status and amblyopia severity in children. A paper has been published (Leon A, Donahue SP, Morrison DG, Estes RL, Li C. 2008. Journal of AAPOS 12:150-156 (PMID: 18155938))
49. Drs. Alejandro Leon, Amy Chomsky (11/2005 - 06/2006): Study of surgery time improvement on ophthalmology residents. A poster has been presented at ARVO meeting.
50. Drs. Christina Bui, Sean Donahue (11/2005 - 06/2006): Study of the treatment effect of amblyopia. A poster has been presented at ARVO meeting.
51. Dr. Lori Kehler (09/2005 - 07/2006): Comparison of a compact visual acuity screener (Optec 800) with the gold standard eye chart (ETDRS). As a result, a manuscript has been submitted.
52. Dr. Jiyang Cai (07/2005 - 08/2006): Relationship of soluble Fas ligand (sFasL) with age, age-related macular degeneration, and expression of proteins such as cystatin S. A paper has been published (Jiang S, Moriarty-Craige SE, Li C, Lynn MJ, Cai J, Jones DP, Sternberg P. 2008. Investigative Ophthalmology & Visual Science 49:1345-1349 (PMID: 18385048))
53. Dr. Denis O’Day (04/2005 - 2006): Evaluation of ophthalmology residency training programs in the United States. We have done initial analysis on the available data. I have given a seminar at the Department of Biostatistics on this topic and Denis has given a presentation at AOS meeting (O’Day DM, Li C. 2006. Transactions of the American Ophthalmological Society 104:129-142 (PMID: 17471333)). The paper is published (O’Day DM, Li C. 2008. Archives of Ophthalmology 126:548-553 (PMID: 18413528)). We have requested for more relevant information that will be incorporated into analysis.
54. Dr. Franco Recchia (06/2005 - 06/2006): Relationship between Cox-2 inhibitor drug use and retinal vein occlusion. This is a retrospective case-control study. We evaluated sample size requirement and plausibility of expanding the study. We also analyzed the current data and plan to incorporate other relevant variables into analysis. A paper has been published (Recchia FM, Chen E, Li C, Maguluri S. 2008. Retina 28:134-137 (PMID: 18185149))

Papers published/submitted

1. O’Day DM, Li C (2006) The failure rate of candidates for board certification: An educational outcome measure. Transactions of the American Ophthalmological Society 104:129-142 (PMID: 17471333)
2. Leon A, Donahue SP, Morrison DG, Estes RL, Li C (2008) The age-dependent effect of anisometropia magnitude on anisometropic amblyopia severity. Journal of AAPOS 12:150-156 (PMID: 18155938)
3. Recchia FM, Chen E, Li C, Maguluri S (2008) Use of COX-2 inhibitors in patients with retinal venous occlusive disease. Retina 28:134-137 (PMID: 18185149)
4. Jiang S, Moriarty-Craige SE, Li C, Lynn MJ, Cai J, Jones DP, Sternberg P (2008) Associations of plasma-soluble Fas ligand with aging and age-related macular degeneration. Investigative Ophthalmology & Visual Science 49:1345-1349 (PMID: 18385048)
5. O’Day DM, Li C (2008) First-time failure rates of candidates for board certification: An educational outcome measure. Archives of Ophthalmology 126:548-553 (PMID: 18413528) (Associated Editorial by John G. Clarkson, Arch Ophthalmol. 2008, 126:562-563)
6. Parbhu KC, Galler KE, Li C, Mawn LA (2008) Underestimation of soft tissue entrapment by computed tomography in orbital floor fractures in the pediatric population. Ophthalmology (in press) (PMID: 18440640)
7. Joos KM, Li C, Calkins DJ (2007) Short-term intermittent elevations in intraocular pressure induce morphometric changes in the rat optic nerve. To Investigative Ophthalmology & Visual Science

Grants pending

Past contacts

1. Dr. Joshua Ki Hu (05/2007): E-mails on comparing two groups for risks of corneal edema.
2. Dr. Prat Itharat, Sean Donahue (05/2007): E-mails on misalignment of the eyes.
3. Dr. David Morrison (02/2007): E-mails on retrospective chart review of children with ROP (retinopathy of prematurity).
4. Dr. Franco Recchia (01/09/2007): We met to discuss study design and sample size requirement for his study on ROP and early birth.
5. Dr. Larry Merin: We met to discuss a potential study using VA diabetics cohort data.
6. Susan Elizabeth Yanni: We met to discuss sample size and multiple comparisons.
7. Dr. Daniel Bustos (05/2006): He e-mailed me to ask for help. I responded but didn't see response.
8. Drs. Rachel and John Kuchtey: We met to discuss sample size and power for a potential study.
9. Dr. David Calkins: We met to discuss a re-submission of his grant application.
10. Dr. Aziz Khanifar: He had a last-minute request on data analysis that could not be done in short time.
11. Dr. Larry Merin: We met to discuss a potential grant application.