Massion Serum MALDI Celebrex-Taxotere Study

• Start Date: 30 Aug 2004
• Research Drive Directory: /Massion/040830/
  • data (data.txt, data_log10.txt) is in ./data/
  • information (info.txt) is in ./data/
• Data Type: MassSpec
• Notes:
• Status:
  1. 100% Complete.
  2. 100% Complete.
  3. 99% Finalization.
  4. 99% Finalization.
  5. PGEM data will be sent later.
  6. 5% Setting up models.

Output

• Q1 Distance: ./distance/top200_all/
• Q2 Distance: ./distance/top200_training_testing/
• Q1, Q2 Score summary: ./data/summary.xls
• Q1, Q2 Eisen summary: ./eisen/eisen.ppt
• Q1, Q2 Distance graphs: ./data/graphs.xls
• Q3 Survival: ./survival/all-31 winners/
• Q3 Survival: ./survival/all-11 winners/

Analysis Requests

1. PD(28) v PR+SD(17) leave one out analysis
   • Determine if pretreatment serum MALDI MS profiling can predict response to treatment
2. PD(14 & 14) v PR+SD(9 & 8) training and testing
3. Survival analysis
   • Begin: Date on study
   • End: Date of death or LDKA
4. Comparison pre/post-serum
   • Find Celecoxib modified proteins
   • Cutoff: p < .0005; wga >= .35; asam >= 3
5. Analysis with PGEM data
6. Cutoff model for class discovery
   • p < .005
   • wga >= .1
   • asam >= 2.5

Change Log:

Contact Info:

• Primary Study Contact Person:

Analysts

• Jeremy Roberts
• Will Gray