Grant Proposals

1. Dr Subramaniam Sriram (8/16) Ongoing
2. Dr Francesca Bagnato (8/16) Ongoing
3. Dr Sid Pawate (6/16) Imaging correlates of cognitive dysfunction in multiple sclerosis
4. Dr Katherine McDonell (4/16) Norepinephrine-targeted Therapy for Action Control in Parkinson Disease
5. Dr Francesca Bagnato (3/16) Study Repair and Neurodegeneration in MS
6. Dr Beth Malow (11/15) Obstructive Sleep Apnea in Children with Neurodevelopmental Disorders: Which Factors Predict CPAP Adherence?
7. Dr Beth Malow (10/15) Obstructive Sleep Apnea in Children with Neurodevelopmental Disorders: Which Factors Predict CPAP Adherence?
8. Dr Whitney Loring (8/12) Sleep Education Program for Adolescents with Autism Spectrum Disorders
9. Drs Beth Malow and Blythe Corbett (8/12) The interplay of HPA axis, anxiety and insomnia in children with ASD
10. Dr Nirupama Madduri (11/12) Evaluating adherence to CPAP in children with Down Syndrome and persistent obstructive sleep apnea
11. Dr Suzanne Goldman (11/12) Personalized treatment for sleep apnea
12. Dr Beth Malow (7/12, 8/12, 9/12) Melatonin Sleep Study
13. Dr Beth Malow (3/12) Measuring Sleep in Autism: Use of Wireless, Comfortable, and Home-Based Tools
14. Dr Loring Whitney (3/12) Sleep Education Program for Adolescents with Autism Spectrum Disorders
15. Dr Blythe Corbett (2/12 - 4/12) Psychobiological investigation of the socioemotional functioning in autism
16. Dr Beth Malow (11/11) Melatonin and Behavioral Sleep Education in Autism: Impact on Child and Family
17. Dr Beth Malow (10/11) Autism Center of Excellence (ACE) Sleep Intervention Network
18. Dr Beth Malow (6/11 - ) Melatonin for sleep in children with autism, a multi-center clinical trial
19. Dr Beth Malow (5/11) Autism Treatment Network Biorepository Protocol
20. Dr Greg Barnes (5/11) The Vanderbilt Natural History Study of Epilepsy in Autism Spectrum Disorders
21. Dr Suzanne Goldman and Beth Malow (5/11) Characterization of the Sleep Phenotype in Adolescents and Young Adults With Autism Spectrum Disorders
22. Dr Suzanne Goldman and Beth Malow (4/11) Maternal sleep problems for children with neurodevelopmental disorders
23. Dr Blythe Corbett (4/11 -) Psychobiological investigation of the socioemotional functioning in autism
24. Dr Beth Malow (3/11-4/11) Sleep Education Program for Adolescents and Young Adults with Autism Spectrum Disorders
25. Dr Blythe Corbett (2/11) Biobehavioral profiles in autism (VICTR applicaiton)
26. Dr Blythe Corbett (1/11 - 2/11) Theatre as a Psychosocial Treatment for Autism
27. Dr Blythe Corbett (12/10 - 3/11) Biobehavioral Exploration of Social Stress in Children with Autism
28. Dr Beth Malow (12/10 - ) A multicenter clinical trial on the effective use melatonin for children with autism
29. Dr Jeremy Veenstra-Vander Weele (10/10) Neurobiological Signatures of Social Dysfunction and Repetitive Behavior
30. Dr Beth Malow (3/10) Treating Insomnia in Children with Autism: Effects of Supplemental Melatonin and Behavioral Sleep Education
31. Matthew Morris and Dr Judy Garber (11/09) Markers of Risk for Mood Problems.
32. Dr David Cole (9/09) Power analysis based on mixed models
33. Dr Beth Malow (12/09) MELATONIN FOR SLEEP IN AUTISM: A DOSE-RESPONSE STUDY.
34. Drs Malano and Malow (9/09) CHARACTERIZATION of REM SLEEP BEHAVIOR DISORDER USING CLINICAL FEATURES AND QUANTITATIVE POLYSOMNOGRAPHY.
35. Drs Robinson and Malow (9/09) EEG analysis of patients with Angelman syndrome.
36. Drs Leu and Malow (7/09) DOD grant, Genotypic Causes of Insomnia in Children with Autism Spectrum Disorders
37. Dr Beth Malow (6/09) Supplement to existing RO1, relation of endogenous melatonin, serotonin and related metabolites in children with ASD and insomnia.
38. Dr Suzaan Goldman and Beth Malow (2/09) EDA,actigraphy, and PSG for characterization of sleep patterns of children with ASD.
39. Dr Greg Barnes and Dr Malow (5/09) Genetic Pathways in Autism Spectrum Disorders
40. Dr Beth Malow (2/09 -)Treatment of Obstructive Sleep Apnea in Adults with Epilepsy.
41. Dr Suzaan Goldman and Beth Malow (2/09) Characterization of the Sleep Phenotype in Adolescents and Young Adults With Autism Spectrum Disorders.
42. Dr Beth Malow (2/09) Treating Obstructive Sleep Apnea in Adults with Epilepsy
43. Drs Leu and Malow (2/09) Genotypic Causes of Insomnia in Children with Autism Spectrum Disorders.
44. Dr Beth Malow (6/08) Sleep Project for Autism Treatment Network HRSA Application. To pilot and operationalize a sleep education program for parents of children with autism spectrum disorders (ASD) that can be disseminated to community pediatric practices.
45. Drs Suzaan Goldman and Beth Malow (3/08) Sleep Architecture and association of sleep and behavior in children with Angelman Syndrome.
46. Drs Suzaan Goldman and Beth Malow (12/07) ASSOCIATION OF OBSTRUCTIVE SLEEP APNEA AND GLYCEMIC RELAPSE IN TYPE 2 DIABETES: A PILOT STUDY
47. Drs Beth Malow and others (10/07) A Sleep Habits Questionnaire for Children with Autism Spectrum Disorders
48. Drs John Mori and Beth Malow (9/07) Effectiveness of diagnositic tools on predicting causes of persistent sleepiness.
49. Dr Beth Malow (9/07)Prospective cohort study to detect the effect of health literacy on CPAP adherence.
50. Dr Hewlett, OCD/Tourette Program (8/06 - 2/07) Differential effects of 3 week and 12 week fluxoetine treatment on mRNA expression in mouse brain regional preparations. Microarray study.
51. Dr Ford Ebner, Department of Psychology (5/06) Intrinsic circuit failure after sensory deprivation in rats. Analysis of pilot Affymetrix microarray data and assistance with grant preparation.
52. Dr Ron Salomon, Department of Psychiatry (4/06 - 5/06 )Mass Spectrometry data.
53. Dr Beth Malow (2/06)Autism Speaks Foundation grant.
54. Dr Beth Malow (11/05 - 1/06, 10/06, 7/07 resubmissions) Melatonin for Insomnia in Children with Autism: Safety, Tolerability, and Optimal Dosing. Design of a dose titration clinical trial. Bayesian analysis.
55. Dr Julia Noland, Department of Psychology and Human Development(5/05, 2/06)Asistance with a K01 grant studying cognitive control in young alcohol and drug exposed children. Sample size calculation for QTDT and obtain information on allele frequencies for SNP using OMIM and the SNP databases.

Manuscripts

1. Dr Blythe Corbett (9/12) Improvement in Social Deficits in Autism Spectrum Disorders Using a Theatre-based, Peer-mediated Intervention
2. Dr Beth Malow (9/12,10/12) EDA project (Report)
3. Dr Suzanne Goldman (4/12, 5/12, 9/12) Child Sleep and Behavior as are Associated With Maternal Sleep and Daytime Sleepiness
4. Dr Blythe Corbett (2/12) Peers, play and performance for enhancing social interactions in youth with autism spectrum disorders
5. Drs Matt Morris and Judy Garber (7/11 -) Stress reactivity and regulation in young adults at varied risk for depression
6. Dr Beth Malow (5/11 - ) Analysis of melatonin datasets
7. Drs Zhongming Zhao and Herbert Meltzer (1/10 - 7/11) Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data
8. Drs Zhongming Zhao and Herbert Meltzer (8/10-11/10) Pathway-based analysis of GWAS datasets: effective but caution required.
9. Dr Matt Morris (8/10 -) Markers of Risk for Mood Problems
10. Dr Beth Malow (8/10 - 3/11) A Pilot Study of Shoulder Placement for Actigraphy in Children (Report)
11. Matt Judson and Dr Pat Levitt (2/10-3/10) EVIDENCE OF CELL-NONAUTONOMOUS CHANGES IN DENDRITE AND DENDRITIC SPINE MORPHOLOGY IN THE MET-SIGNALING DEFICIENT MOUSE FOREBRAIN. (Report)
12. Drs Roberta Leu and Beth Malow (12/09-) Genotypic Causes of Insomnia in Children with Autism Spectrum Disorders.
13. Drs Roberta Leu and Beth Malow (11/09-) Relation of Nocturnal Urinary 6-SM to sleep in Children with Autism. (Report)
14. Dr Kendal Brodie (4/09 -2/10) Structural mass spectrometry analysis of lipid changes in a drosophila epilepsy model brain
15. Amand Mitchell (Mirnics Lab) (2/09 -) Gene expression correlates of spontaneous physical activity in the motor cortex and striatum. (Report)
16. Dr Suzanne Goldman (11/08) Defining the Sleep Phenotype in Children with Autism.
17. Dr Beth Malow (10/08) Sleep Education Workshops for Parents of Children with Autism Spectrum Disorders - A Pilot Study.
18. Dr Stacy Killen and Alfred George (9/08-1/09) SCN5A Allelic Expression Imbalance in African-Americans Heterozygous for the Common Variant p.Ser1103Tyr. (Report)
19. Dr Beth Malow (5/08-6/08) Analysis of National Alliance for Autism Research (NAAR)study dataset. Sleep parameters and Children’s Sleep Habits Questionnaire (CSHQ).
20. Dr Stefania Bonaccorso, Department of Psychiatry (8/07 - 5/08) Activation of serotonin metabolism and BDNF changes in depressed patients with multiple sclerosis during interferon-beta before and after pharmacologic and non-pharmacologic intervention. Mixed models analysis of repeated measures.
21. Dr Beth Malow, (11/07-2/08) A Sleep Habits Questionnaire for Children with Autism Spectrum Disorders.
22. Dr Beth Malow, Department of Neurology (8/07 - 11/07)Treatment of Obstructive Sleep Apnea in Adults with Epilepsy: A Placebo-Controlled Pilot Study Using Sham CPAP.
23. Dr Stefania Bonaccorso, Department of Psychiatry (7/07 - 8/07) Randomized clinical trial on MS patients treated with interferon-beta affected by mood disorder. Repeated measures analysis.
24. Dr Beth Malow, Department of Neurology (2/07)Sleep Staging and Respiratory Events in Refractory Epilepsy Patients: Is there a First Night Effect? Agreement study.
25. Dr Beth Malow (1/07) Variability in actigraphy measurements in children with autism spectrum disorders. Random effect models.
26. Drs Ramon Cuevas and Beth Malow, Department of Neurology (7/06 - ) Assessment of Sleep in Children with Autism Spectrum Disorders: A Comparison of Actigraphy and Video-Polysomnography.
27. Dr Beth Malow, Department of Neurology (3/06 - 5/06) Sleep in Children with Autism Spectrum Disorders: A multidimensional approach.
28. Dr Alex Bonnin, Department of Pharmacology (3/06)Serotonin is a potent modulator of responsiveness to classic axon guidance cues by thalamocortical axons.
29. Drs Sue Mcgrew and Beth Malow, Department of Neurology (11/05 - 1/07)Sleep patterns in children with autism. Internal and external validation of questionnaires.
30. Dr Sodhi Monsheel, Department of Psychiatry (11/05 - ) Meta Analysis of allelic association between the 5-HT2c receptor cys23ser polymorphism and clinical response to clozapine. Random effect model using Proc Mixed (REML) and fully Bayesian approach.
31. Dr William Siesser, Center for Molecular Neuroscience (10/05 - 1/06)Studying the effects of psychostimulants on the locomotor activity of the TRbetaPV knock-in mice. Analysis of repeated experimental measurements.

Data Analysis and Consultations

1. Drs Hacker and Charles (8/16) Deep Brain simulation, two papers.
2. Dr Shilpi Mittal (5/16) VICTR
3. Dr Amanda Peltier (5/16) R34
4. Dr Francesca Bagnato (4/16) R2* and histology data analysis
5. Dr Sid Pawate (4/16) R01 (submitted in June)
6. Dr Katherine Katherine (3/16) VICTR resubmission (submitted April)
7. Dr Amanda Peltier (2/16) R01
8. Dr Sid Pawate (2/16) R01
9. Dr Francesca Bagnato (2/16) K-award (submitted March)
10. Dr Sid Pawate (1/16) R01
11. Dr Francesca Bagnato (1/16) K-award
12. Jingqiong Kang (11/15) VICTR
13. Dr Beth Malow (9/15) Grants for CPAP Adherence: PCORI and DOD (submitted in Oct and Nov)
14. Dr Blythe Corbett (7/12, 9/12) Analysis of cortisol data
15. Dr Suzanne Goldman (4/12) Impact of Sleep on Family Functioning
16. Dr Randy Blakely (6/11) Analysis of G56A Phosphoproteome dataset (Report)
17. Dr Shin Yamazaki (4/11) Effects of environmental factors on mammalian circadian rhythms.
18. Dr Al George (11/10) Discussions on analysis of metagenomics studies
19. Dr Suzanne Goldman (6/10) Analysis of ATN datasets
20. David Lund (Blakely Lab) (2/10) Discussion on mixture distribution
21. Dr Roger Taylor (1/10) Sequential analyses of cognitive and affective state transitions in middle school science classrooms.
22. Dr Beth Malow (12/09 -) MELATONIN FOR SLEEP IN AUTISM: A DOSE-RESPONSE STUDY. abstract submitted 12/15/09
23. Drs Leu and Malow (11/09-) Insomnia in children with ASD: is there a genetic contribution? (Report)
24. Neil Dani (Brodie lab) (11/09) Analysis on Drosophila data.
25. Dr Beth Malow (11/09) Melatonin for Insomnia in Children with Autism (Report)
26. Dr Kendal Broadie (5/09) Analysis of biological lipid species. (Report)
27. Dr Károly Mirnics (2/09-3/11) Physical Activity Related Gene Expression in the Motor Cortex
28. Brett English (Blakely Lab) (2/09) Analysis of exercise echo values for Het vs. wild type mice.
29. David Lund (Blakely Lab) (10/08) Brief consultations on study planning.
30. Dr Brett English (Blakely Lab) (5/08 - 7/08) Heart rate analysis. Nolinear mixed models, plots for paper.
31. Dr Stefania Bonaccorso, Department of Psychiatry (5/07) BDNF changes among sample of depressed patients after long term treatment with SSRI. Analysis of longitudinal data.
32. Dr Inma Ballesteros, (8/07, 2/08)Quantitative analysis of the morphological features of neurons in a mutant mouse line; poster presented at Spanish conference: Alteraciones permanentes en neuronas piramidales por la exposición prenatal a cocaína.
33. Dr Beth Malow (2/08) Sleep study prediction problem. Hidden Markov Models.
34. Dr Christine Koradi, Department of Psychiatry. (1/08) Microarray data analysis.
35. Dr Aurea Pimenta, Ph.D., Research Assistant Professor of Pharmacology (03/07)Sample size calculations for neuron study.
36. Nellie Byun, Center for Molecular Neuroscience (03/07)Quantitating the myelin and axonal defects in the K-Cl cotransporter-3 (KCC3) knockout mice, a model for the neurological disorder ACCPN. Brief consultation.
37. Dr Sodhi Monsheel, Psychpharmacology Division, Department of Psychiatry (12/04 - 2/05)Studying 5-HT2A and 5-HT2C receptors in the etiology and treatment of psychiatric illness. Analysis using QT-TDT test (Quantative Trait Transmission Disequilibrium Test ) with QTDT software.
38. Dr Gregg Stanwood,Department of Pharmacology (8/05)Microarray study, identifying differentially expressed genes.
39. Douglas P. Sladen, Dept. of Hearing and Speech Sciences (9/05)Discussion of the paper "The intelligibility of speech with ‘‘holes’’ in the spectrum" by Kalyan Kasturi et al.
40. Dr. Xin Chen, Kennedy Center (9/05)How joint attention affects infants’ object processing. Sample size calculation. Assistance with grant application.
41. Nellie Byun, Center for Molecular Neuroscience (10/05)Quantitating the myelin and axonal defects in the K-Cl cotransporter-3 (KCC3) knockout mice, a model for the neurological disorder ACCPN. Sample size calculation.
42. Dr Aurea Pimenta, Ph.D., Research Assistant Professor of Pharmacology (10/05)Microarray study, normalization.
43. Dr. Karen L. Gamble, the Department of Biological Sciences (10/05)Statistical analysis method on in situ hybridization data, a 2X2 factorial design with unequal variances.
44. Dr David H Zald, Department of Psychology (10/05)The association between taste sensitivity and oral temperature sensitivity. Statistical analysis of repeated measurements.
45. Tian, Mengnan, Department of Pharmacology (11/05) Quantifying the influence of RGS4 knockout on GTPγS binding after carbachol mediated muscarinic receptor stimulation. Sample size calculation.
46. Kennedy Center Statistics and Methodology Core 2005 Vanderbilt Kennedy Center Quantitative Services Survey. Analysis of survey results.
47. Becky Breeding, McLaughlin Lab, Department of Neurology (12/05 - 1/06)Brain Structure and Function after Fetal Cocaine. Statistical analysis of doubly repeated measurements. Missing value imputation.
48. Dr Paul J. Yoder, Department of Neuroscience Services & Special Education (1/06)Goodness of fit test based on ranks.
49. Dr Vicki S. Harris, Department of Psychology and Human Development (1/06)Assistance with data management of SPSS data.
50. Hayley Arnold, Department of Hearing and Speech Sciences (5/06) EMOTIONAL REACTIVITY, REGULATION AND CHILDHOOD STUTTERING: A BEHAVIORAL,ELECTROPHYSIOLOGICAL STUDY. Discussion on statistical analysis for thesis.
51. Carol Nixon, Department of Psych & Human Development (5/06) Pattern mixture models for longitudinal data.
52. Nellie Byun, Center for Molecular Neuroscience (5/06)Quantitating the myelin and axonal defects in the K-Cl cotransporter-3 (KCC3) knockout mice, a model for the neurological disorder ACCPN. Discussion on statistical analysis for thesis.
53. Dr Fiona Harrison, Department of Pharmacology (5/06) Discussion on the analysis of multivariate repeated measurements.
54. Alyson Abel, Department of Hearing and Speech Sciences (5/06) Sample size calculation for repeated measures analysis. Discussion of analysis for thesis.
55. Dr Terry Page, Department of Biological Sciences (6/06)Analysis of circadian rhythms data, using circular stat to evaluate what appear to be bimodal rhythms (two peaks of activity per day).
56. Manuel Riemer, Center for Evaluation and Program Improvement (6/06) Discussion of statistical analysis for thesis. Equivalence testing.
57. Dr BethAnn McLaughlin, Department of Neurology (7/06) Evaluating the changes in mitochondrial membrane potential induced by isoprostanes under normal and hypoxic conditions. Discussion of analysis for data.
58. Mengnan Tian, Department of Pharmacology (8/06) Evaluate how intronic mutation IVS6+2T-->G affects mRNA expression of GABRG2 gene with homozygous and heterozygous expressions. Discussion of analysis for thesis.
59. Dr Karoly Mirnics, Department of Psychiatry (8/06) Microarray data analysis for Nimblegen match case-control study data. Gene enrichment analysis.