Biostatistics Weekly Seminar

Despite decades of controversy, p-values remain a popular tool for assessing when the data are incompatible with the null hypothesis. While it is widely recognized that p-values are imperfect, the consequences of ignoring their flaws remain elusive and p-values continue to flourish in the scientific literature. In this talk, I will introduce the second-generation p-value, a novel and intuitive extension that better serves the intended purpose. Second-generation p-values are the proportion of data-supported hypotheses that are contained in an interval null hypothesis that consists of all null, practically null, and scientifically uninteresting effects. This emphasis on scientific relevance obviates the need for multiple comparisons adjustments and reduces false discovery rates. I will discuss the statistical properties of second-generation p-values and illustrate their use in a high-dimensional analysis of genetic markers for Leukemia.

MRBIII, Room 1220
5 December 2018
1:30pm