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(26 Apr 2013,
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---+++ Department of Biostatistics Seminar/Workshop Series ---+ <a name="Bayesian_Adaptive_Trials_in_Practice"></a> Bayesian Adaptive Trials in Practice ---++ <a name="Jason_Connor_PhD"></a> Jason Connor, !PhD ---+++ <a name="Berry_Consultants"></a> Berry Consultants ---+++ <a name="Wednesday_July_14_1_30_2_30pm"></a> Wednesday, July 14, 1:30-2:30pm, MRBIII Conference Room 1220 I will describe Bayesian adaptive designs used in regulatory trials with pharmaceuticals companies and medical device makers. These include a range of prospective adaptations including adaptive selection of sample size, frequent updating of randomization probabilities, altering inclusion criteria to focus on patients in whom a therapy provides benefit, and adaptive seamless Phase 2/3 designs. I will illustrate two particular designs: a Phase 2 dose- finding trial incorporating adaptive randomization and a Phase 3 confirmatory trial using predictive probabilities and a longitudinal model updated throughout patient accrual to select the optimal sample size.
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Topic revision: r2 - 26 Apr 2013,
JohnBock
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