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IGP 304: Statistics for Biomedical Research
Instructor: Chun Li, Ph.D. (chun.li@vanderbilt.edu; 515D Light Hall; 322-2884)Assistant: David Reif (david.m.reif@vanderbilt.edu; 511K Light Hall)
Lectures: MWF 2-2:50 pm, 306AB Light Hall
Office hours: MWF after class
Syllabus
Textbook and reading materials
- [EMS] Essential Medical Statistics. We will cover most chapters, with additional materials from other sources. (amazon.com link)
- [SN] Statistics Notes. Fifty-one valuable short articles on misuses and correct uses of statistics in medical research.
- [LHSP] Little Handbook of Statistical Practice
- [CFA] Checklist for Authors. A collection of misuses of statistics.
- Glossary of Statistical Terms
Software
- Intercooled Stata 9: official site and UCLA Stata support site
- R 2.2: official site and R Clinic
- Stata is also available at the College of Arts & Science Microcomputer Labs
- David's handout on Stata Basics
- Chun's Stata notes and R notes
Stata Labs
Students' datasets
Homework and exams
- Homework 1 (due on Monday, January 23) HW1 Keys
- Homework 2 (due on Monday, February 6) HW2 Keys
- Homework 3 (due on Monday, February 20) HW3 Keys
- Midterm Exam Keys
- Homework 4 (due on Wednesday, April 5) HW4 Keys
- Homework 5 (due on Wednesday, April 19) HW5 Keys
- Final Exam Keys
Chun's experimental course blog
Lectures
| Date | To read/do before class | Topics | |
|---|---|---|---|
| 1 | 01/11 (W) | Get the textbook and software | Course description; software demostration |
| 2 | 01/13 (F) | EMS 1-2; LHSP Is statistics hard?; SN 15 Presentation of numerical data | Ryan's question on dichotomization; Data import and entry; data types; diagnostic quiz |
| 3 | 01/16 (M) | Stata lab; EMS 3; The scandal of poor medical research and correspondence 1, correspondence 2 | Simpson's paradox; variable collection, coding, and checking; spreadsheets from hell and heaven; summary of diagnostic quiz |
| 4 | 01/18 (W) | Stata lab; EMS 3; SN 13 Absence of evidence is not evidence of absence | EMS 3: Descriptive/exploratory analysis |
| 5 | 01/20 (F) | Stata lab; EMS 4-5; SN 51 Standard deviations and standard errors; SN 10 The normal distribution | EMS 4; discuss all assigned reading materials |
| 6 | 01/23 (M) | Stata lab; EMS 6; SN 18 Transformations, means and confidence intervals | HW1 due; EMS 5-6 |
| 7 | 01/25 (W) | Stata lab; EMS 6-7 | |
| 8 | 01/27 (F) | EMS 7 | Bob's question on comparing two groups of changes; EMS 7 |
| 9 | 01/30 (M) | Stata lab; EMS 8 | |
| 10 | 02/01 (W) | Stata lab; EMS 9 | |
| 11 | 02/03 (F) | Stata lab; EMS 9 | analysis of variance |
| 12 | 02/06 (M) | Stata lab; EMS 10 | HW2 due; simple linear regression |
| 13 | 02/08 (W) | Stata lab; EMS 11 | Judith's survey study; EMS 11 |
| 14 | 02/10 (F) | Stata lab; EMS 12 | |
| 15 | 02/13 (M) | Ecological fallacy and here; EMS 13 | |
| 16 | 02/15 (W) | EMS 13-14 | |
| 17 | 02/17 (F) | EMS 14-15 | |
| 18 | 02/20 (M) | EMS 15 | HW3 due; other scheduled coverage |
| 19 | 02/22 (W) | EMS 16-17 | Sylvie's study on inflammatory process and oxidative damage; EMS 16-17 |
| 20 | 02/24 (F) | Stata lab; EMS 17 | |
| 21 | 02/27 (M) | EMS 18 | |
| 22 | 03/01 (W) | EMS 18 | |
| 03/03 (F) | Midterm exam | ||
| 03/04-03/12 | Spring break | ||
| 23 | 03/13 (M) | EMS 19 | Logistic regressions |
| 24 | 03/15 (W) | Stata lab; EMS 19-20 | Logistic regressions |
| 25 | 03/17 (F) | EMS 20-21 | |
| 26 | 03/20 (M) | EMS 21 | |
| 27 | 03/22 (W) | EMS 22 | |
| 28 | 03/24 (F) | EMS 23 | |
| 29 | 03/27 (M) | Guest lecture by Dr. Rafe Donahue | |
| 30 | 03/29 (W) | Guest lecture by David Reif | |
| 31 | 03/31 (F) | Guest lecture by Dr. David Airey, notes | |
| 32 | 04/03 (M) | EMS 23, 26 | Comparing rates; basic concepts in survival analysis |
| 33 | 04/05 (W) | EMS 26-27 | HW4 due; Survival analysis |
| 04/07 (F) | No class due to CHGR event | ||
| 34 | 04/10 (M) | EMS 30 | Nonparametrics |
| 35 | 04/12 (W) | EMS 36 | ROC curve; regression to the mean |
| 36 | 04/14 (F) | EMS 37 | |
| 37 | 04/17 (M) | EMS 34 | |
| 38 | 04/19 (W) | EMS 35 | HW5 due; other scheduled coverage |
| 39 | 04/21 (F) | EMS 38 | |
| 40 | 04/24 (M) | ||
| 04/26(W) | Final exam at 1-3 pm in 433 Light Hall | ||
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Topic revision: r69 - 30 Oct 2006, ChunLi
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