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InfDisReport
(28 Apr 2006,
BryanShepherd
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---+ Summary of Collaborative Work with Infectious Disease Division last updated 12/01/05 *HIV EPI/OUTCOMES GROUP* * *Group leader: Tim Sterling* * _CD4 Number/Percent_ * *Investigators*: Todd Hulgan, Tim Sterling, Steve Raffanti * _Completed Work_: * Analysis looking at predictive power of CD4% for time until AIDS defining event or death. * Abstract submitted * Paper being written * Evaluated predictive ability of model using bootstrap * Examined predictive ability of model on independent JHU data (collaboration with Richard Moore). * Begun statistical methods paper about bootstrapping the PH assumption * _Next Task_: * Finish CD4% paper * Decide what to do with JHU/bootstrap analyses * Methods paper about bootstrapping proportional hazards assumption * _Race and Sex Difference in Causes of Death_ * *Investigators*: Diana Lemley, Steve Raffanti * _Completed Work_: * Multivariable logistic regression analysis * Abstract submitted to CROI * Paper submitted to AIDS short communications * _Next Task_: * Wait to hear what happens * _Efavirinz vs Boosted PI Study_ * *Investigators*: Tim Sterling * _Completed Work_: * Read about marginal structural models * Possibility of intern to help * _Next Task_: * Learn more about MSM * Program MSM code to run on simulation * Implement once Gema and gang have validated key variables * Sensitivity analysis? * _Other Projects with Involvement/Consulting_ * Jennifer Tai (OC3 project) * Gema Barkanic, David, Todd (substance abuse project; grant submitted) * Wes Shealey (resistance mutations project; 2 abstracts submitted) * Andrew Desruisseau (Hepatitis C project discussions) * Maria Pia De Pasquele (power calculations, help with analyses) *OTHER* * _Tom Talbot's Grant Application_ * Study design for methods to reduce the rate of false positive contaminant blood cultures: * Randomized block design * Analysis plan for interrupted time series design: * Poisson regression with # cathedar days of risk as offset, adjusting for new treatment, time using splines, interaction of time and treatment, and assuming AR(1) correlation structure * _CCASANet Grant Application_ * *Investigators*: Daniel Masys, Richard d'Aquila, and others * _Completed Work_: * General description of analyses * Statistical Methods section of grant: sensitivity analyses and incorporating sampling weights into phylogenetic analysis * Grant funded! * _Immune recognition of mycobacerial antigens by sarcoidosis PBMC_ * *Investigators*: Wonder Drake * _Completed Work_: * Basic comparisons using Fisher's Exact Test, Chi-square tests, and Kruskal-Wallis * Two abstracts submitted * Paper submitted: "Immune recognition of mycobacterial antigen 85A by sarcoidosis peripheral blood mononuclear cells" * Helping with revision of different paper * _General Consulting_ * Lora Thomas: * Review of journal club article where Frank was wrongly acknowledged * Monthly journal club involvement. * Answering questions for ID faculty/students. * _Vikrant Sahasrabuddhe and Stan Vermund_ * Statistical advice and analysis of Zambia HPV dataset (12/15/05) * Reviewed paper -- waiting to see next manuscript * _Dirk Meyer-Olsen_ * Former post-doc fellow in Spyros Kalams lab * Statistical advice on analysis looking at biomarkers and time until CD4 value halves (12/12/05)
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Topic revision: r6 - 28 Apr 2006,
BryanShepherd
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