Summary of Collaborative Work with Infectious Disease Division

• Group leader: Tim Sterling

• CD4 Number/Percent
  • Investigators: Todd Hulgan, Tim Sterling, Steve Raffanti
  • Completed Work:
    • Analysis looking at predictive power of CD4% for time until AIDS defining event or death.
    • Abstract submitted
    • Paper being written
    • Evaluated predictive ability of model using bootstrap
    • Examined predictive ability of model on independent JHU data (collaboration with Richard Moore).
    • Begun statistical methods paper about bootstrapping the PH assumption
  • Next Task:
    • Finish CD4% paper
    • Decide what to do with JHU/bootstrap analyses
    • Methods paper about bootstrapping proportional hazards assumption

• Race and Sex Difference in Causes of Death
  • Investigators: Diana Lemley, Steve Raffanti
  • Completed Work:
    • Multivariable logistic regression analysis
    • Abstract submitted to CROI
    • Paper submitted to AIDS short communications
  • Next Task:
    • Wait to hear what happens

• Efavirinz vs Boosted PI Study
  • Investigators: Tim Sterling
  • Completed Work:
    • Read about marginal structural models
    • Possibility of intern to help
  • Next Task:
    • Learn more about MSM
    • Program MSM code to run on simulation
    • Implement once Gema and gang have validated key variables
    • Sensitivity analysis?

• Other Projects with Involvement/Consulting
  • Jennifer Tai (OC3 project)
  • Gema Barkanic, David, Todd (substance abuse project; grant submitted)
  • Wes Shealey (resistance mutations project; 2 abstracts submitted)
  • Andrew Desruisseau (Hepatitis C project discussions)
  • Maria Pia De Pasquele (power calculations, help with analyses)

• Tom Talbot's Grant Application
  • Study design for methods to reduce the rate of false positive contaminant blood cultures:
    • Randomized block design
  • Analysis plan for interrupted time series design:
    • Poisson regression with # cathedar days of risk as offset, adjusting for new treatment, time using splines, interaction of time and treatment, and assuming AR(1) correlation structure

• CCASANet Grant Application
  • Investigators: Daniel Masys, Richard d'Aquila, and others
  • Completed Work:
    • General description of analyses
    • Statistical Methods section of grant: sensitivity analyses and incorporating sampling weights into phylogenetic analysis
    • Grant funded!

• Immune recognition of mycobacerial antigens by sarcoidosis PBMC
  • Investigators: Wonder Drake
  • Completed Work:
    • Basic comparisons using Fisher's Exact Test, Chi-square tests, and Kruskal-Wallis
    • Two abstracts submitted
    • Paper submitted: "Immune recognition of mycobacterial antigen 85A by sarcoidosis peripheral blood mononuclear cells"
    • Helping with revision of different paper

• General Consulting
  • Lora Thomas:
    • Review of journal club article where Frank was wrongly acknowledged
  • Monthly journal club involvement.
  • Answering questions for ID faculty/students.

• Vikrant Sahasrabuddhe and Stan Vermund
  • Statistical advice and analysis of Zambia HPV dataset (12/15/05)
  • Reviewed paper -- waiting to see next manuscript

• Dirk Meyer-Olsen
  • Former post-doc fellow in Spyros Kalams lab
  • Statistical advice on analysis looking at biomarkers and time until CD4 value halves (12/12/05)