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(18 Mar 2021,
AndrewSpieker
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%HEAD{ NAME="Holly Janes, !PhD" AFFILIATION="Fred Hutchinson Cancer Research Center" TITLE="Design of current and future COVID-19 vaccine efficacy trials" IMAGELINK="https://www.fredhutch.org/content/dam/www/faculty-photos/J/holly-janes/holly-janes.jpg" }% Rapid development and deployment of safe and effective COVID-19 vaccines for the global population is a public health imperative. We will overview the key statistical design elements of the first-generation US-government-funded vaccine efficacy trials, including the rationale and choice of endpoints, success criteria, triggers for analysis, and design adaptations following early evidence of efficacy. The implications of the emerging results for second-generation trials to evaluate additional vaccine candidates and to complete the profile of existing vaccines will be discussed. <br><br> %TAIL{DATE="24 March 2021"}% <!-- * Set HEAD = <div class="w3-card-2" id="task" style="max-width:750px; margin-left: 0px;"> <header class="w3-container w3-blue" style="padding:40px"><h1>Biostatistics Weekly Seminar</h1><br><h2 style="color:white;">%TITLE%<br><br>%NAME%<br>%AFFILIATION%</h2></header><div class="w3-container" style="padding:40px"><IMG SRC=%IMAGELINK% align="left" id="mug"/> * Set TAIL = <br><h3>Zoom (Link to Follow)<br>%DATE%<br>1:30pm</h3></div></div><br>[[%TOPIC%Itinerary][Speaker Itinerary]] --> <style> .w3-card-2,.w3-example{box-shadow:0 2px 4px 0 rgba(0,0,0,0.16),0 2px 10px 0 rgba(0,0,0,0.12)!important} .w3-blue,.w3-hover-blue:hover{color:#fff!important;background-color:#2196F3!important} .w3-container{padding:0.01em 16px} .foswikiTopic {font-family: 'Open Sans', sans-serif;} /* Removes location hierarchy (usually written in grey text) */ .patternHomePath {display:none;} /* Removes bar with edit and attach buttons and location hierarchy */ .patternTop{display:none;} h1, h2, h3, h4, h5, h6{font-family: 'Montserrat','Open Sans', sans-serif;font-weight:700;} h1, h2, h3, h4, h5, h6{color:#bf1735;} h1:first-of-type{color:#2a3e6e;margin-bottom:25px;margin-top:5px;} .foswikiImage{margin-left:-9px;} img#mug{padding-right: 40px; padding-bottom:25px; height:250px;} </style>
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Topic revision: r2 - 18 Mar 2021,
AndrewSpieker
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