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HWECC
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---+++ <nop>HWECC: Hardy-Weinberg test for case-control data URL of this page: [[http://biostat.mc.vanderbilt.edu/HWECC][http://biostat.mc.vanderbilt.edu/HWECC]] This [[%ATTACHURL%/HWECC.r][program]] is written in R ([[http://www.r-project.org][www.r-project.org]]). The main function is =HWECC()=, which uses three other internal functions =fun1()=, =fun2()=, and =fun3()=. For example, for a SNP with case genotype counts 61, 48, 23 and control genotype counts 98, 77, 9, if the disease prevalence is 0.06, the p-value is obtained by calling <verbatim> HWECC(prev=0.06, case=c(61,48,23), control=c(98,77,9)) </verbatim> The paper that describes the method is: Li M, Li C (2008) Assessing departure from Hardy-Weinberg equilibrium in the presence of disease association. Genetic Epidemiology 32:589-599 (PMID: 18449919) ([[http://www3.interscience.wiley.com/journal/118964735/abstract][paper]]) <!-- * Set ALLOWTOPICCHANGE = ChunLi * Set TOPICLAYOUTURL = /twiki/pub/Main/ChunLi/ChunLiLayout.css * Set TOPICSTYLEURL = /twiki/pub/Main/ChunLi/ChunLiStyle.css -->
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Topic revision: r2 - 28 Apr 2009,
ChunLi
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