Guanhua (Josh) Chen, PhD Assistant Professor
email: gchen25@wisc.edu

Research Interests

• Statistical Learning/ Machine Learning
• Personalized Medicine
• High Dimensional Medical Records/Genetic Data
• Semiparametric Methods
• Survival Analysis

Curriculum Vitae

CV (last updated Aug 2014)

Vanderbilt Collaborations

• Biomedical Informatics

Published Papers

• Methodology

1. Bush WS, Chen G, Torstenson ES and Ritchie MD: LD-Spline: LD-Spline: Mapping SNPs on genotyping platforms to genomic regions using patterns of linkage disequilibrium, BioData Mining, 2009, 2:2-7
2. Chen G, Sullivan PF, Kosorok MR: Biclustering with heterogenous variance. Proceedings of the National Academy of Sciences, 2013, 110(30): 12253-12258. Code: HSSVD
3. Chen G, Liu Y, Shen D, Kosorok MR: Composite large margin classifiers with latent subclasses. Statistical Analysis and Data Mining, 2016, 9(2): 75-88.
4. Chen G, Zeng D, Kosorok MR: Personalized dose finding using outcome weighted learning (with discussion). Journal of the American Statistical Association, 2016, in press.
5. Tang ZZ^, Chen G^, Alekseyenko A: Hypothesis Testing for Microbiome Profile. (^ for equal contribution and corresponding authors) Bionformatics, 2016, 32(17): 2618-2625.
6. Zhu R, Zhao YQ, Chen G, Ma S, Zhao H: Greedy Tree Learning of Optimal Personalized Treatment Rules. Biometrics, 2016, in press.
7. Tang ZZ, Chen G, Alekseyenko A, Li H: A general framework for association analysis of microbial community on a taxonomic tree. Bionformatics, 2016, in press.

• Collaborative

1. Bloom RJ, Kahler AK, Collins AL, Chen G, Cannon TD, Hultman C, Sullivan PF: Comprehensive analysis of copy number variation in monozygotic twins discordant for bipolar disorder or schizophrenia. Schizophrenia Research, 2013, 146(1-3):289-290.
2. Wright FA, Sullivan PF, ... , Chen G , ... , Boomsma DI: Heritability and genomics of gene expression in peripheral blood. Nature Genetics, 2014, 46:430-437.
3. Szatkiewicz J, O'Dushlaine CT, Chen G , Sullivan PF: Copy number variation in Schizophrenia in Sweden. Molecular Psychiatry, 2014, 19:762-773
4. Jhamb M, Cavanaugh K, Bian A, Chen G , Ikizler TA, Unruh ML, Abdel-Kader K: Disparities in Electronic Health Record Patient Portal Use in Nephrology Clinics: Correlates and Outcomes. Clinical Journal of the American Society of Nephrology, 2015, 10(11): 2013-2022.
5. Deger SM, Huang AM, Ellis CD, Booker C, Bian A, Chen G, Abumrad NN, Ikizler TA: High Dose Omega-3 Fatty Acids Attenuate Skeletal Muscle Protein Breakdown in Maintenance Hemodialysis Patients. Clinical Journal of the American Society of Nephrology , 2016, 11(7): 1227-1235.
6. Leaf, DE, Christov M, Jupner H, Siew E, Ikizler TA, Bian A, Chen G, Sabbisetti VS, Bonventre JV, Wolf M, Waikar SS: FGF23 and Cardiac Surgery-Associated Acute Kidney Injury. Kidney International , 2016, 89(4):939-948.
7. Denny GB, Deger SM, Chen G, Bian A, Feng S, Booker CA, Kesler JT, David S, Ellis CD, Ikizler TA: Leucine disposal rate for assessment of amino acid metabolism in maintenance hemodialysis patients. BMC Nutrition, 2016, 2(1): 31.
8. Kensinger C, Bian A, Fairchild M, Chen G, Lipworth-Elliot L, Ikizler TA, Birdwell KA: Long term evolution of endothelial function during kidney transplantation. BMC Nephrology, 2016, 17(1): 160.
9. Kensinger C, Hernandez A, Bian A, Fairchild M, Chen G, Lipworth-Elliot L, Ikizler TA, Birdwell KA: Longitudinal Assessment of Cardiac Morphology and Function Following Kidney Transplantation. accepted in Clinical Transplantation, 2016.

Technical report

1. Liu Q, Chen G, Kosorok MR, Bair E: Biclustering Via Sparse Clustering. arxiv:1407.3010
2. Zhu R, Zhao YQ, Chen G: Stabilized Dynamic Treatment Regime.
3. Chen G: Variable screening for classification with measurement error in the class label.

Software/Code

HSSVD: R package that performs biclustering, which allows heterogeneous variance.

Useful Links