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DiffTimePoint
(29 Oct 2004,
JoanZhang
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---+ Susan Study * Start Date: 09 Sep 2004 * Research Drive Directory: Kasper/040603/ * Data Type: <nop>MassSpec * Notes: * Status: 1 normal: 100% complete 2 tumor: 100% complete ---+++ Output ---+++ Analysis Requests : 2 data sets - normal and tumor ---++++ Normal * originally it has 9 time points, the investigator combine them into 6 time points<br> * four samples in each time points : AP VP DP LP, each sample is the average of 6 mice. ---++++ Tumor * 4 time points and 3 samples (AP VP DLP—DLP is the combination of DP&LP) ---+++++ Step I: based on normal find out proteins that have the following pattern | timepoint | ½ | 3 | 4/5 | 6 | 10/15 | 40 | |cond | N | N | F | F | F | F | |cond | N | N | N | F | F | F | |cond | N | F | F | F | F | F | |cond | F | N | F | F | F | F | |cond | F | F | N | F | F | F | |cond | F | F | N | N | N | N | |cond | F | N | N | N | N | N | Totally generate 7 conds * 4 sample types (AP VP DP LP)= 28 ---+++++ Step II: pair wised comparison totally 6*5=30 based on normal set(data from step I result 1-5). * AP vs. VP * AP vs. DP * AP vs. LP * VP vs. DP * VP vs. LP * DP vs. LP ---+++++ Step III: based on tumor set:get the pattern from step I, based on pattern 1-5, find out following patterns: * AP week10 week15<br> ON ON<br> OFF ON<br> ON OFF<br> * VP week 12 week17<br> ON ON<br> OFF ON<br> ON OFF<br> * DLP week10 week15<br> ON ON<br> OFF ON<br> ON OFF<br> ---+++ Output * summary sheet: \KASPER\040603\deliverable * normal data set: \KASPER\040603\deliverable\normal_result * tumor data set: \KASPER\040603\deliverable\tumor_result ---+++ Change Log: * Sept. 22th: change timepoint of cloumn AK from 1 week to 12 weeks * Sept. 22th: delete 3 samples of 18 weeks in tumor data set. * Oct. 4th: change column AK type VP back into week 1. * Oct. 22th: change question #1 and #3 in tumor set (change week18 to week15) ---+++ Contact Info: * Primary Study Contact Person: Susan Kasper ---+++ Analysts * Main.NimishGautam * Main.JoanZhang
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Topic revision: r5 - 29 Oct 2004,
JoanZhang
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