Collaboration with Dr. Michael DeBaun

Completed Items

• SAC-I data hub (Wenli's project)
  • Wants to receive data from SAC I multiple centers and store them as one large merged data set
  • Wenli to collect all data sets and documentation, and at least one data request
  • Dale and Jeremy to create database merge of files and produce scripts to generate data requests
• SAC-III
  • Creation of a 2nd VICTR database (REDCap) with Beth Malow
• SAC-II data hub (Wenli's project)
  • Wants to receive data from SAC II multiple centers and store them as one large merged data set
  • Data will be available for queries and distribution to analysts
  • A similar structure was used by Avril Adelman (Wash U) for SAC-I
  • Dale will identify IT person to organize this; Wenli has time to assist and manage data afterwards
  • Project goal - have everything in place by Aug 1st (funding for Avril ends Aug 31)
• SAC-I
  • Secondary analyses, have templates and questions already defined
  • To meet the week of May 2nd and have Wenli program analyses
• SIT Feasibility Trial submission
  • Needs me to write stats section for VICTR Application
  • Currently has multicenter R01 at Wash U: Silent Cerebral Infarct Trial
  • Wants to resubmit the R01 with a new treatment arm
  • Needs small, 2-site (UAB & Hopkins) feasibiility trial for proof of concept using REDCap
  • Wants to use Vandy as Coordinating Center
  • Will submit for funding through VICTR
  • Robert Sidonio- has K award to dedicate 75% of effort to the project
  • Frank: add aim about lesion size to get dose/response relationship instead of binary outcome
    • Use logistic regression to identify risk factors or subgroups that lead to 20-30% change in risk
    • 1st thing: Plot histogram of predictive risk
    • Frank suggests 7.5% PhD, 30% MS through VICTR for 2-3 years
  • Also wants statistician to visit 6 sites in Fall (Hopkins, Boston, UCSF, Pittsburgh, Cincinnati, etc.)