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DavidBenkeser20220302
(25 Feb 2022,
JenaAltstatt
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%HEAD{ NAME="David Benkeser, !PhD" AFFILIATION="Assistant Professor</br> Biostatistics and Bioinformatics, Rollins School of Public Health </br> Emory University" TITLE="Statistical issues in the immune correlates analysis of the mRNA-1273 vaccine efficacy trial" IMAGELINK="https://apps.sph.emory.edu/RSPHPeople/files/pictures/BIOS%20Headshots%202019-052.jpg" }% Identifying immune responses that are predictive of vaccine efficacy is an important goal of COVID-19 vaccine research. Discovery of such immune responses, termed vaccine correlates of protection, can lead to accelerated approval of new vaccines and existing vaccines in new populations. One important source of information for identification of correlates of protection is data from Phase 3 efficacy studies of vaccines. In this talk, I will describe some statistical issues surrounding correlates analysis in the context of a recent analysis of the U.S. Phase 3 trial of the mRNA-1273 (Moderna) vaccine. The talk will be a mix of scientific results from our study, statistical methods, and general musings on causality as it relates to identifying causal mechanisms of vaccines. %TAIL{DATE="02 March 2022"}% <!-- * Set HEAD = <div class="w3-card-2" id="task" style="max-width:750px; margin-left: 0px;"> <header class="w3-container w3-blue" style="padding:40px"><h1>Biostatistics Weekly Seminar</h1><br><h2 style="color:white;">%TITLE%<br><br>%NAME%<br>%AFFILIATION%</h2></header><div class="w3-container" style="padding:40px"><IMG SRC=%IMAGELINK% align="left" id="mug"/> * Set TAIL = <br><h3>Zoom (Link to Follow)<br>%DATE%<br>1:30pm</h3></div></div><br>[[%TOPIC%Itinerary][Speaker Itinerary]] --> <style> .w3-card-2,.w3-example{box-shadow:0 2px 4px 0 rgba(0,0,0,0.16),0 2px 10px 0 rgba(0,0,0,0.12)!important} .w3-blue,.w3-hover-blue:hover{color:#fff!important;background-color:#2196F3!important} .w3-container{padding:0.01em 16px} .foswikiTopic {font-family: 'Open Sans', sans-serif;} /* Removes location hierarchy (usually written in grey text) */ .patternHomePath {display:none;} /* Removes bar with edit and attach buttons and location hierarchy */ .patternTop{display:none;} h1, h2, h3, h4, h5, h6{font-family: 'Montserrat','Open Sans', sans-serif;font-weight:700;} h1, h2, h3, h4, h5, h6{color:#bf1735;} h1:first-of-type{color:#2a3e6e;margin-bottom:25px;margin-top:5px;} .foswikiImage{margin-left:-9px;} img#mug{padding-right: 40px; padding-bottom:25px; height:250px;} </style>
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Topic revision: r1 - 25 Feb 2022,
JenaAltstatt
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