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DandanLiu31Oct2018
(03 Feb 2022,
ThomasStewart
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%HEAD{ NAME="Dandan Liu, !PhD" AFFILIATION="Vanderbilt University Medical Center" TITLE="Target Population Risk Prediction with Time-to-Event Outcome" IMAGELINK="https://www.vumc.org/biostatistics/sites/default/files/people/Liu_Dandan.jpg" }% Most existing risk prediction tools for time-to-event outcomes were developed using large epidemiologic cohorts. Although these data sources are often of high quality, their external generalizability to a much broader population, termed target population in this paper, may be limited. Many external validation studies of existing risk prediction tools have shown adequate discrimination but poor calibration which is largely driven by the differences in the baseline hazard between the sourcing cohort and the target population. In this paper, we developed a statistical method to reconcile this discrepancy by incorporating the composite incidence of the target population in the development of risk prediction tools using the sourcing cohort. An individualized absolute risk prediction tool could then be improved using the proposed baseline hazard estimator. The asymptotic properties of the proposed absolute risk estimators were established. Simulation studies examining small sample properties of the proposed estimators were conducted. The proposed methods will be illustrated using the Womens Health Initiative Observational Study and Canary Prostate Active Surveillance Study. %TAIL{DATE="31 October 2018"}% <!-- * Set HEAD = <div class="w3-card-2" id="task" style="max-width:750px; margin-left: 0px;"> <header class="w3-container w3-blue" style="padding:40px"><img src="https://biostat.app.vumc.org/wiki/pub/Main/DandanLiu31Oct2018/nv-flag-seal-shape2.png", style="width:200px;padding-right:40px;" align="left"><p class="nvday">NV Day Biostatistics Seminar</p><br><br><h2 style="color:white;">%TITLE%<br><br>%NAME%<br>%AFFILIATION%</h2></header><div class="w3-container" style="padding:40px"><IMG SRC=%IMAGELINK% align="right" id="mug"/> * Set TAIL = <br><h3>MRBIII, Room 1220<br>%DATE%<br>1:30pm</h3></div></div><br> --> <style> .w3-card-2,.w3-example{box-shadow:0 2px 4px 0 rgba(0,0,0,0.16),0 2px 10px 0 rgba(0,0,0,0.12)!important} .w3-blue,.w3-hover-blue:hover{color:#fff!important;background-color:#ab640080!important;padding-left: 40px; padding-right: 40px; padding-top: 20px; padding-bottom: 20px;} .w3-container{padding:0.01em 16px} .foswikiTopic {font-family: 'Open Sans', sans-serif;} /* Removes location hierarchy (usually written in grey text) */ .patternHomePath {display:none;} /* Removes bar with edit and attach buttons and location hierarchy */ .patternTop{display:none;} h1, h2, h3, h4, h5, h6{font-family: 'Montserrat','Open Sans', sans-serif;font-weight:700;} h1, h2, h3, h4, h5, h6{color:#0047ab;} h1:first-of-type{color:#0047ab;margin-bottom:25px;margin-top:5px;} .foswikiImage{margin-left:-9px;} img#mug{padding-left: 40px; padding-bottom:25px; height:250px;} .nvday{ font-size: 20pt; font-weight: 800; color: #0047ab; margin-top:0px; margin-bottom:10px; } </style>
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Topic revision: r2 - 03 Feb 2022,
ThomasStewart
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