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%HEAD{ NAME="Daniel Scharfstein, !ScD" AFFILIATION="Chief of the Division of Biostatistics<br>Department of Population Health Sciences<br>University of Utah School of Medicine" TITLE="Semi-Parametric Sensitivity Analysis for Trials with Irregular and Informative Assessment Times" IMAGELINK="https://medicine.utah.edu/sites/g/files/zrelqx476/files/styles/portrait_phone/public/media/images/2022/Dan%20Scharfstein.jpg" }% Many trials are designed to collect outcomes at or around pre-specified times after randomization. In practice, there can be substantial variability in the times at which participants are actually assessed. As a result, treatment effects can be driven by the timing of assessments, rather than the effect of treatment on participants' underlying outcome trajectories. To avoid this problem, it is better to focus on the treatment effect at each of the (fixed) targeted assessment times. For this, untestable assumptions are needed. Therefore, it is important to assess how inferences would change under departures from these assumptions via sensitivity analysis. We develop such a sensitivity analysis methodology here, along with a semi-parametric, influence function-based estimation approach. We apply our method to a study of low-income participants with uncontrolled asthma, and we evaluate the performance of our procedure in a realistic simulation study. This is joint work with Bonnie Smith, Shu Yang and Andrea Apter. %TAIL{DATE="24 February 2023"}% <!-- * Set HEAD = <div class="w3-card-2" id="task" style="max-width:750px; margin-left: 0px;"> <header class="w3-container w3-blue" style="padding:40px"><h1>Biostatistics Weekly Seminar</h1><br><h2 style="color:white;">%TITLE%<br><br>%NAME%<br>%AFFILIATION%</h2></header><div class="w3-container" style="padding:40px"><IMG SRC=%IMAGELINK% align="left" id="mug"/> * Set TAIL = <br><h3>Hybrid: Meeting Room and Zoom Link to Follow<br>%DATE%<br>9:00am</h3></div></div><br>[[%TOPIC%Itinerary][Speaker Itinerary]] --> <style> .w3-card-2,.w3-example{box-shadow:0 2px 4px 0 rgba(0,0,0,0.16),0 2px 10px 0 rgba(0,0,0,0.12)!important} .w3-blue,.w3-hover-blue:hover{color:#fff!important;background-color:#2196F3!important} .w3-container{padding:0.01em 16px} .foswikiTopic {font-family: 'Open Sans', sans-serif;} /* Removes location hierarchy (usually written in grey text) */ .patternHomePath {display:none;} /* Removes bar with edit and attach buttons and location hierarchy */ .patternTop{display:none;} h1, h2, h3, h4, h5, h6{font-family: 'Montserrat','Open Sans', sans-serif;font-weight:700;} h1, h2, h3, h4, h5, h6{color:#bf1735;} h1:first-of-type{color:#2a3e6e;margin-bottom:25px;margin-top:5px;} .foswikiImage{margin-left:-9px;} img#mug{padding-right: 40px; padding-bottom:25px; height:250px;} </style>
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Topic revision: r1 - 16 Feb 2023,
CierraStreeter
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