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JohnHarrell
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---++ Education *Ph.D. in Biostatistics, March 2005* * The Johns Hopkins University, Department of Biotatistics, Baltimore MD * Advisor: Assistant Professor Brian S. Caffo * Co-advisor: Professor Charles Rohde * Thesis Title "Modelling Biomedical Data and the Foundations of Bioequivalence" *M.S. in Physical Pharmacy, February 1995* * Seoul National University School of Pharmacy, Seoul, Korea * Thesis Title "Solubilization of Cyclosporin A using Liposomes and Mixed Micelles, and Pharmacokinetics after Intravenous Administration" *B.S. in Pharmacy, February 1988* * Seoul National University School of Pharmacy, Seoul, Korea ---++ Professional Experience *Assistant Professor, September 2005-Present* * Vanderbilt University, Department of Biostatistics *Statistical Consultant, 2000 - 2005* * Johns Hopkins Biostatistics Consulting Center * Statistical short courses * Nonlinear mixed models in pharmaceutical research: a case study with real data, July 24, 2002 * Nonlinear mixed models for pharmacokinetics and pharmacodynamics: application to QT data, December 11, 2002 * Walk-in clinic * Dr. Craig W. Hendrix group, Johns Hopkins School of Medicine, Department of Clinical Pharmacology * Dr. Jennifer Haythornthwaite group, Johns Hopkins School of Medicine, Department of Psychiatry-Behavioral Medicine Clinic * Dr. Gary Wand group, Johns Hopkins School of Medicine, Department of Medicine and Psychiatry *Regulatory Agent, 1995-1999* * Korea Food and Drug Administration, Seoul, Korea *Pharmacist, 1990-1991* * Daehak Drug Store, Seoul, Korea *Reporter, 1989-1990* * The Journal of Clinical Pharmacy, Seoul, Korea *Volunteer Worker, 1987-1988* * The Anglican Church, Youngdung-po, Seoul, Korea ---++ Research Interests Interesting problems involving pharmacokinetic and pharmacodynamic modelling, Bioequivalence and Structural modelling (Mechanistic modelling) ---++ Peer Reviewed Publications 1 *Choi, L.*, Dominici, F., Zeger, S.L. and Ouyang, P. Estimating Treatment Efficacy over Time: a Logistic Regression Model for Binary Longitudinal Outcomes. _Statistics in Medicine_, 24:2789-2805, 2005. 1 Lee, M.K., *Choi, L.*, Kim, M.H. and Kim, C.K. Pharmacokinetics and Organ Distribution of Cyclosporin A Incorporated in Liposomes and Mixed Micelles. _International Journal of Pharmaceutics_, 191:87-93, 1999. 1 Kim, C.K., Chung, H.S., Lee, M.K., *Choi, L.N.* and Kim, M.H. Development of Dried Liposomes Containing β-Galactosidase for the Digestion of Lactose in Milk. _International Journal of Pharmaceutics_, 183:185-193, 1999. ---++ Peer Reviewed Collaborative Publications 1 Ndovi, T.T., Choi, L., Caffo, B., Parsons, T., Baker, S., Zhao, M., Rohde, C. and Hendrix, C.W. Quantitative assessment of seminal vesicle and prostate drug concentrations by use of a noninvasive method. _Clinical Pharmacology and Therapeutics_, 80(2): 146-158, 2006. 1 Oswald, L.M., Wong, D.F., <nop>Trash.McCaul, M., Zhou, Y., Kuwabara, H., *Choi, L.*, Brasic, J. and Wand, G.S. Relationships among ventral striatal dopamine release, cortisol secretion and subjective responses to amphetamine. _Neuropsychopharmacology_, 30(4), 821-832, 2005. 1 Uhart, M., <nop>Trash.McCaul, M., Oswald, L.M., *Choi, L.* and Wand, G.S. GABRA6 gene polymorphism and an attenuated stress response. _Molecular Psychiatry_, 9(11):998-1006, 2004. 1 Oswald, L.M., <nop>Trash.McCaul, M., *Choi, L.*, Yang, X. and Wand, G.S. Catechol-O-methyltransferase polymorphism alters hypothalamic-pituitary-adrenal axis responses to naloxone: a preliminary report. _Biological Psychiatry_, 55(1):102-105, 2004. 1 Lawler, L.P., Horton, K.M., Scatarige, J.C., Phelps, J., Thompson, R.E., *Choi, L.* and Fishman, E.K. Coronary artery calcification scoring by prospectively triggered multidetector-row computed tomography: is it reproducible? _Journal of Computer Assisted Tomography_, 28(1):40-45, 2004. ---++ Manuscripts under review/revisions and technical reports 1 *Choi, L.*, Caffo, B.S., Rohde, C., Ndovi, T.T. and Hendrix, C.W. A Mechanistic Latent Variable Model for Estimating Drug Concentrations in the Male Genital Tract. Technical Report. [[http://www.bepress.com/jhubiostat/paper79/ Download a copy here.]] 1 *Choi, L.*, Caffo, B.S. and Rohde, C. Optimal Sampling Times in Bioequivalence Studies Using a Simulated Annealing Algorithm. Technical Report. [[http://www.bepress.com/jhubiostat/paper59/ Download a copy here.]] ---++ Presentations * A case study for estimating efficacy of a stomach disorder treatment in clinical trials. Jonhs Hopkins University Bloomberg School of Public Health Department of Biostatistics 2003 Retreat, April 25-27, 2003. * Evaluation for the Reference Standards of Glipizide and Glibenclamide. 1996 Research Presentation, Korea Food and Drug Administration, 4 February, 1997. * Development of Dry Liposomes Containing β-Galactosidase for the Digestion of Lactose in Milk. Liposome Research Days Conference - Liposomes: the Next Generation, University of British Columbia, Vancouver, Canada, 19 June - 22 June, 1994. ---++ Awards, Honors and Liscences * Phi Beta Kappa, May 2005. * Korea Food and Drug Administration Best Presentation Award from the Commissioner of Korea Food and Drug Administration, February 1997. * Registered air environmental engineer, Korea, July 24 1995. * Registered pharmacist, Korea, March 13 1989.
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Topic revision: r10 - 29 Jul 2008,
JohnHarrell
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