Active surveillance cohort in CEASAR

Aims: (1) Describe reasons patients come off AS (question 8 of 3-year survey). (2) Describe which patients come off AS.

Cohort definition/Inclusion and Exclusion Criteria:

• No active treatment within one year (n = 505) OR {indication of AS on

medical chart or survey (bl, 6m, 12m) AND no active treatment within 6 months (n = 33)} --> n = 538 For example, these patients would be excluded and considered to be in an "active treatment cohort"

• anyone receiving treatment within the first 6 months. (even if their

surveys and chart say AS)

• anyone receiving treatment between 6 and 12 months after dx who have

no indication of AS on chart or surveys Analysis: Aim 1: Frequency table and proportion estimate with CI. Aim 2: Survival model with time to active treatment as response. All model covariables would be exposures of interest, since the objective of this model is to identify predictors. I think all the predictors should be baseline predictors. We will use age, comorbidity, d’amico risk, race, and a SES indicator or two. Mark wants to include the PDM and a RAND quality indicator. Mark suggested including a nelson-aalen curve to show the cumulative incidence of treatment within this cohort over time.

Meeting notes

pandora ad, tv commercial, npr story, website, clinic pamphlets, local newspapers, billboard, ad on fox news, google ads, google optimization, churches, **regional issues. website would be the heart of it.

2015 November25

2015 November 23

• Refined aims to the above.
• One major task is defining the AS cohort for this sub study.
• When patients go on AS, they typically have a PSA test every 3 months and a repeat biopsy within 12 months. If the PSA is elevated, they might have a repeat biopsy sooner. We would expect very few patients to have a repeat biopsy by 6 months. This info is useful for defining the study cohort. We want to exclude patients who got an active treatment by some time point after dx, and we need to define that cutoff. The earliest it would be is probably 6 months, and the latest it would be is 12 months.
• We want to incorporate info from the chart about AS.
• Need to include checks for people who indicated on a survey or chart that they are undergoing AS. Decided to integrate the treatment info with chart or patient report of AS.
• Proposed defn: no active treatment within one year OR (indication on chart or bl, 6m, or 12m survey AND no active treatment within 6 months).

-- JoAnnAlvarez - 04 Jan 2016