You are here:
Vanderbilt Biostatistics Wiki
>
Main Web
>
Seminars
>
WednesdaySeminarSeries
>
BingxinZhao10192022
(05 Dec 2022,
CierraStreeter
)
(raw view)
E
dit
A
ttach
%HEAD{ NAME="Bingxin Zhao, !PhD" AFFILIATION="Assistant Professor of Statistics and Data Science</br>University of Pennsylvania" TITLE="Some statistical analyses on polygenic risk scores: genetic applications of random matrix theory" IMAGELINK="https://media.science.purdue.edu/uploads/statcentral/05df07275cd6b56e22b157fa1e0cb9684a8c2e0a8a3ab3a795f50414ec14deea.jpg?_ga=2.140274864.2003570268.1663602069-849766719.1663602069" }% Numerous statistical models have been proposed for genetic prediction using high-dimensional data from genome-wide association studies. The relative performance of these methods varies with the dataset characteristics and underlying genetic architecture of the targeted traits/diseases. Motivated by empirical observations, we present a series of analyses on genetic prediction methods in a high-dimensional sparsity-free setting, where we are allowed to have few to many true signals. In particular, I will present our analyses of two statistical problems. In the first project, we quantify the asymptotic bias when estimating genetic relationships with other traits based on polygenic risk scores ( [[https://arxiv.org/abs/2203.12154][Zhao, Yang, and Zhu, 2022, arXiv]]). The second project is to understand the impact of reference panels on genetic prediction accuracy ( [[https://arxiv.org/abs/2203.12003][Zhao, Zheng, and Zhu, 2022, arXiv]]). These analyses are based on recent advances in random matrix theory. %TAIL{DATE="19 October 2022"}% <!-- * Set HEAD = <div class="w3-card-2" id="task" style="max-width:750px; margin-left: 0px;"> <header class="w3-container w3-blue" style="padding:40px"><h1>Biostatistics Weekly Seminar</h1><br><h2 style="color:white;">%TITLE%<br><br>%NAME%<br>%AFFILIATION%</h2></header><div class="w3-container" style="padding:40px"><IMG SRC=%IMAGELINK% align="left" id="mug"/> * Set TAIL = <br><h3>Hybrid: Meeting Room and Zoom Link to Follow<br>%DATE%<br>1:30pm</h3></div></div><br>[[%TOPIC%Itinerary][Speaker Itinerary]] --> <style> .w3-card-2,.w3-example{box-shadow:0 2px 4px 0 rgba(0,0,0,0.16),0 2px 10px 0 rgba(0,0,0,0.12)!important} .w3-blue,.w3-hover-blue:hover{color:#fff!important;background-color:#2196F3!important} .w3-container{padding:0.01em 16px} .foswikiTopic {font-family: 'Open Sans', sans-serif;} /* Removes location hierarchy (usually written in grey text) */ .patternHomePath {display:none;} /* Removes bar with edit and attach buttons and location hierarchy */ .patternTop{display:none;} h1, h2, h3, h4, h5, h6{font-family: 'Montserrat','Open Sans', sans-serif;font-weight:700;} h1, h2, h3, h4, h5, h6{color:#bf1735;} h1:first-of-type{color:#2a3e6e;margin-bottom:25px;margin-top:5px;} .foswikiImage{margin-left:-9px;} img#mug{padding-right: 40px; padding-bottom:25px; height:250px;} </style>
E
dit
|
A
ttach
|
P
rint version
|
H
istory
: r3
<
r2
<
r1
|
B
acklinks
|
V
iew topic
|
Edit
w
iki text
|
M
ore topic actions
Topic revision: r3 - 05 Dec 2022,
CierraStreeter
Main
Department Home Page
Biostatistics Graduate Program
Vanderbilt University Medical Center
Main Web
Main Web Home
Search
Recent Changes
Changes
Topic list
Biostatistics Webs
Archive
Main
Sandbox
System
Register
|
Log In
Copyright © 2013-2022 by the contributing authors. All material on this collaboration platform is the property of the contributing authors.
Ideas, requests, problems regarding Vanderbilt Biostatistics Wiki?
Send feedback