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AndrewSpieker20210120
(18 Jan 2021,
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%HEAD{ NAME="Andrew Spieker, !PhD" AFFILIATION="Vanderbilt University Medical Center" TITLE="Bounding local average treatment effects in studies of engagement with mobile interventions" IMAGELINK="https://www.vumc.org/biostatistics/sites/default/files/people/spiekera.jpeg" }% Estimation of local average treatment effects in randomized trials typically requires an assumption known as the exclusion restriction in cases where we are unwilling to rule out unmeasured confounding. Under this assumption, any benefit from treatment would be mediated through the post-randomization variable being conditioned upon, and would be directly attributable to neither the randomization itself nor its latent descendants. Recently, there has been interest in mobile health interventions to provide healthcare support; such studies can feature one-way content and/or two-way content, the latter of which allowing subjects to engage with the intervention in a way that can be objectively measured on a subject-specific level (e.g., proportion of text messages receiving a response). It is hence highly likely that a benefit achieved by the intervention could be explained in part by receipt of the intervention content and in part by engaging with/responding to it. When seeking to characterize average causal effects conditional on post-randomization engagement, the exclusion restriction is therefore all but surely violated. We propose a conceptually intuitive sensitivity analysis procedure for this setting that gives rise to sharp bounds on local average treatment effects. A wide array of simulation studies reveal this approach to have very good finite-sample behavior and to recover local average treatment effects under correct specification of the sensitivity parameter. We apply our methodology to a randomized trial evaluating a text message-delivered intervention for Type 2 diabetes self-care. %TAIL{DATE="20 January 2021"}% <!-- * Set HEAD = <div class="w3-card-2" id="task" style="max-width:750px; margin-left: 0px;"> <header class="w3-container w3-blue" style="padding:40px"><h1>Biostatistics Weekly Seminar</h1><br><h2 style="color:white;">%TITLE%<br><br>%NAME%<br>%AFFILIATION%</h2></header><div class="w3-container" style="padding:40px"><IMG SRC=%IMAGELINK% align="left" id="mug"/> * Set TAIL = <br><h3>Zoom (Link to Follow)<br>%DATE%<br>1:30pm</h3></div></div><br> --> <style> .w3-card-2,.w3-example{box-shadow:0 2px 4px 0 rgba(0,0,0,0.16),0 2px 10px 0 rgba(0,0,0,0.12)!important} .w3-blue,.w3-hover-blue:hover{color:#fff!important;background-color:#2196F3!important} .w3-container{padding:0.01em 16px} .foswikiTopic {font-family: 'Open Sans', sans-serif;} /* Removes location hierarchy (usually written in grey text) */ .patternHomePath {display:none;} /* Removes bar with edit and attach buttons and location hierarchy */ .patternTop{display:none;} h1, h2, h3, h4, h5, h6{font-family: 'Montserrat','Open Sans', sans-serif;font-weight:700;} h1, h2, h3, h4, h5, h6{color:#bf1735;} h1:first-of-type{color:#2a3e6e;margin-bottom:25px;margin-top:5px;} .foswikiImage{margin-left:-9px;} img#mug{padding-right: 40px; padding-bottom:25px; height:250px;} </style>
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Topic revision: r1 - 18 Jan 2021,
AndrewSpieker
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