You are here:
Vanderbilt Biostatistics Wiki
>
Main Web
>
Seminars
>
WednesdaySeminarSeries
>
AnEfficientProcedureToCombineBiomarkersWithLimitsOfDetectionForRiskPrediction
(04 Apr 2018,
KathrynStoltzfus
)
(raw view)
E
dit
A
ttach
-- Main.KathrynStoltzfus - 04 Apr 2018 An efficient procedure to <span style="background-color: transparent;">combine biomarkers with limits of detection for risk prediction</span> Much research seeks biomarkers for diagnosing disease and understanding disease etiology. As high-throughput technologies allow measuring multiple markers simultaneously, and particularly if no single marker is highly discriminating, strategies for combining markers are needed. In collaborations on studies of inflammation markers and cancer risk I faced the challenge of correlated markers with appreciable percentages of values outside the limits of detection of the assays. Only a few procedures have been proposed so far that address how to combine information from multiple correlated markers that are also left and/or right censored due to lower or upper limits of detection. We extend dimension reduction approaches, specifically likelihood-based sufficient dimension reduction (LDR) to regression or classification with censored predictors. These methods apply generally to any type of outcome, including continuous and categorical outcomes. Using an expectation maximization (EM) algorithm, we find linear combinations that contain all the information contained in correlated markers for modeling and prediction of an outcome variable, while accounting for left and right censoring due to detection limits. We also allow for selection of important variables through penalization. We assess the performance of our methods extensively in simulations and apply them to data from a study conducted to assess associations of 47 inflammatory markers and lung cancer risk and build prediction models. This is joint work with Diego Tomassi, Liliana Forzani and Efstathia Bura E
E
dit
|
A
ttach
|
P
rint version
|
H
istory
: r1
|
B
acklinks
|
V
iew topic
|
Edit
w
iki text
|
M
ore topic actions
Topic revision: r1 - 04 Apr 2018,
KathrynStoltzfus
Main
Department Home Page
Biostatistics Graduate Program
Vanderbilt University Medical Center
Main Web
Main Web Home
Search
Recent Changes
Changes
Topic list
Biostatistics Webs
Archive
Main
Sandbox
System
Register
|
Log In
Copyright © 2013-2022 by the contributing authors. All material on this collaboration platform is the property of the contributing authors.
Ideas, requests, problems regarding Vanderbilt Biostatistics Wiki?
Send feedback