You are here:
Vanderbilt Biostatistics Wiki
>
Main Web
>
Seminars
>
WednesdaySeminarSeries
>
AmirAsiaeetaheri14Feb2020
(12 Feb 2020,
TawannaPeters
)
(raw view)
E
dit
A
ttach
%HEAD{ NAME="Amir Asiaee Taheri, !PhD" AFFILIATION="Ohio State university" TITLE="Disjunctive Bayesian Network Infers Cancer Progression Network" IMAGELINK="https://opic.osu.edu/asiaeetaheri.1?aspect=p&width=300" }% Cancer is an evolutionary process that can be modeled as a sequence of genetic alterations throughout the tumor cell population. Each new driver alteration confers a selective growth advantage to the cell and sweeps through the population, which results in clonal expansion. But the order in which accumulating alterations occur is not arbitrary. Inferring the order of events leading to cancer has been shown to have diagnostic and prognostic importance but is a challenging problem due to the lack of longitudinal samples from tumors. In this talk, I am going to discuss our novel scalable algorithm for inferring cancer progression networks. To model cancer progression, we introduce the Disjunctive Bayesian Network (DBN), which is a discrete Bayesian Network (BN) with a particular family of local conditional probability distributions. We then use a genetic algorithm to learn the structure of DBN from cross-sectional cancer data. We characterize an equivalence relation over DBNs and speed up our algorithm by restricting our search space to a single representative graph of each equivalence class. Finally, we show that the progression networks inferred by our method for colon, bladder, and skin cancers match the biological facts known about these cancers. %TAIL{DATE="14 February 2020"}% <!-- * Set HEAD = <div class="w3-card-2" id="task" style="max-width:750px; margin-left: 0px;"> <header class="w3-container w3-blue" style="padding:40px"><h1>Biostatistics Weekly Seminar</h1><br><h2 style="color:white;">%TITLE%<br><br>%NAME%<br>%AFFILIATION%</h2></header><div class="w3-container" style="padding:40px"><IMG SRC=%IMAGELINK% align="left" id="mug"/> * Set TAIL = <br><h3>2525 WEA Suite 1100 Conf Room 11105A<br>%DATE%<br>2:30pm</h3></div></div><br>[[%TOPIC%Itinerary][Speaker Itinerary]] --> <style> .w3-card-2,.w3-example{box-shadow:0 2px 4px 0 rgba(0,0,0,0.16),0 2px 10px 0 rgba(0,0,0,0.12)!important} .w3-blue,.w3-hover-blue:hover{color:#fff!important;background-color:#2196F3!important} .w3-container{padding:0.01em 16px} .foswikiTopic {font-family: 'Open Sans', sans-serif;} /* Removes location hierarchy (usually written in grey text) */ .patternHomePath {display:none;} /* Removes bar with edit and attach buttons and location hierarchy */ .patternTop{display:none;} h1, h2, h3, h4, h5, h6{font-family: 'Montserrat','Open Sans', sans-serif;font-weight:700;} h1, h2, h3, h4, h5, h6{color:#bf1735;} h1:first-of-type{color:#2a3e6e;margin-bottom:25px;margin-top:5px;} .foswikiImage{margin-left:-9px;} img#mug{padding-right: 40px; padding-bottom:25px; height:250px;} </style>
E
dit
|
A
ttach
|
P
rint version
|
H
istory
: r3
<
r2
<
r1
|
B
acklinks
|
V
iew topic
|
Edit
w
iki text
|
M
ore topic actions
Topic revision: r3 - 12 Feb 2020,
TawannaPeters
Main
Department Home Page
Biostatistics Graduate Program
Vanderbilt University Medical Center
Main Web
Main Web Home
Search
Recent Changes
Changes
Topic list
Biostatistics Webs
Archive
Main
Sandbox
System
Register
|
Log In
Copyright © 2013-2022 by the contributing authors. All material on this collaboration platform is the property of the contributing authors.
Ideas, requests, problems regarding Vanderbilt Biostatistics Wiki?
Send feedback