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AmberHackstadt20210127
(18 Jan 2021,
AndrewSpieker
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%HEAD{ NAME="Amber Hackstadt, !PhD" AFFILIATION="Vanderbilt University Medical Center" TITLE="Estimating risk in large public health and comparative effectiveness studies" IMAGELINK="https://www.vumc.org/biostatistics/sites/default/files/people/Hackstadt_headshot.jpg" }% There is an abundance of secondary data sources, including claims data and electronic health records, that provides a valuable resource. These data can inform medical researchers about patient care outside of the clinical trial setting, and in “real world settings” with the potential to greatly improve comparative effectiveness and health services research. Traditional statistical analyses that use observational data may produce biased estimates due to residual confounding. Several studies have supported the use of propensity score weighting to help reduce such bias but few studies have focused on using propensity score weighting for time-to-event outcomes in the presence of competing risks. In this seminar, I will explore the performance of approaches to estimate the cumulative incidence functions for time-to-event outcomes in the presence of competing risks when using propensity score weighting to address the lack of randomization. This project is motivated by a study comparing the effects of the anti-diabetic medications metformin and sulfonylureas after reaching a reduced kidney function threshold. The data sources includes electronic health records for nearly 100,000 US veterans linked to other large administrative sources. Large clinical trials that investigated diabetes treatment effects on cardiovascular outcomes have excluded patients with reduced kidney function, rendering this population understudied. %TAIL{DATE="27 January 2021"}% <!-- * Set HEAD = <div class="w3-card-2" id="task" style="max-width:750px; margin-left: 0px;"> <header class="w3-container w3-blue" style="padding:40px"><h1>Biostatistics Weekly Seminar</h1><br><h2 style="color:white;">%TITLE%<br><br>%NAME%<br>%AFFILIATION%</h2></header><div class="w3-container" style="padding:40px"><IMG SRC=%IMAGELINK% align="left" id="mug"/> * Set TAIL = <br><h3>Zoom (Link to Follow)<br>%DATE%<br>1:30pm</h3></div></div><br> --> <style> .w3-card-2,.w3-example{box-shadow:0 2px 4px 0 rgba(0,0,0,0.16),0 2px 10px 0 rgba(0,0,0,0.12)!important} .w3-blue,.w3-hover-blue:hover{color:#fff!important;background-color:#2196F3!important} .w3-container{padding:0.01em 16px} .foswikiTopic {font-family: 'Open Sans', sans-serif;} /* Removes location hierarchy (usually written in grey text) */ .patternHomePath {display:none;} /* Removes bar with edit and attach buttons and location hierarchy */ .patternTop{display:none;} h1, h2, h3, h4, h5, h6{font-family: 'Montserrat','Open Sans', sans-serif;font-weight:700;} h1, h2, h3, h4, h5, h6{color:#bf1735;} h1:first-of-type{color:#2a3e6e;margin-bottom:25px;margin-top:5px;} .foswikiImage{margin-left:-9px;} img#mug{padding-right: 40px; padding-bottom:25px; height:250px;} </style>
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Topic revision: r1 - 18 Jan 2021,
AndrewSpieker
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