NAME="Dr. Yang Yang, PhD"
AFFILIATION="Professor<?br> Department of Statistics </br>University of Georgia"
TITLE="Statistical challenges in modeling infectious disease transmissions among close contact groups"


Numerous statistical models have been proposed for genetic prediction using high-dimensional data from genome-wide association studies. The relative performance of these methods varies with the dataset characteristics and underlying genetic architecture of the targeted traits/diseases. Motivated by empirical observations, we present a series of analyses on genetic prediction methods in a high-dimensional sparsity-free setting, where we are allowed to have few to many true signals. In particular, I will present our analyses of two statistical problems. In the first project, we quantify the asymptotic bias when estimating genetic relationships with other traits based on polygenic risk scores ( Zhao, Yang, and Zhu, 2022, arXiv). The second project is to understand the impact of reference panels on genetic prediction accuracy ( Zhao, Zheng, and Zhu, 2022, arXiv). These analyses are based on recent advances in random matrix theory.

%TAIL{DATE="19 October 2022"}%

* Set HEAD = <div class="w3-card-2" id="task" style="max-width:750px; margin-left: 0px;"> <header class="w3-container w3-blue" style="padding:40px"><h1>Biostatistics Weekly Seminar</h1><br><h2 style="color:white;">%TITLE%<br><br>%NAME%<br>%AFFILIATION%</h2></header><div class="w3-container" style="padding:40px"><IMG SRC=%IMAGELINK% align="left" id="mug"/>
* Set TAIL = <br><h3>Hybrid: Meeting Room and Zoom Link to Follow<br>01 Oct 2023<br>1:30pm</h3></div></div><br>Speaker Itinerary
.w3-card-2,.w3-example{box-shadow:0 2px 4px 0 rgba(0,0,0,0.16),0 2px 10px 0 rgba(0,0,0,0.12)!important}
.w3-container{padding:0.01em 16px}
.foswikiTopic {font-family: 'Open Sans', sans-serif;}
/* Removes location hierarchy (usually written in grey text) /
.patternHomePath {display:none;}
Removes bar with edit and attach buttons and location hierarchy */
h1, h2, h3, h4, h5, h6{font-family: 'Montserrat','Open Sans', sans-serif;font-weight:700;}
h1, h2, h3, h4, h5, h6{color:#bf1735;}
img#mug{padding-right: 40px; padding-bottom:25px; height:250px;}
Topic revision: r1 - 13 Aug 2023, CierraStreeter

This site is powered by FoswikiCopyright © 2013-2022 by the contributing authors. All material on this collaboration platform is the property of the contributing authors.
Ideas, requests, problems regarding Vanderbilt Biostatistics Wiki? Send feedback