Department of Biostatistics Seminar/Workshop Series

A Comparison of Three Approaches for Constructing Robust Experimental Designs

Vincent Agboto, PhD

Director, Biometrics Core, Clinical Research Center, Meharry Medical College

Wednesday, October 6, 1:30-2:30pm, MRBIII Conference Room 1220

While optimal designs are commonly used in the design of experiments, the optimality of those designs frequently depends on the form of an assumed model. Several useful criteria have been proposed to reduce such dependence, and efficient designs have been then constructed based on the criteria, often algorithmically. In the model robust design paradigm, a space of possible models is specified and designs are sought that are efficient for all models in the space. The Bayesian criterion given by DuMouchel and Jones (1994), posits a single model that contains both primary and potential terms. In this article we propose a new Bayesian model robustness criterion that combines aspects of both of these approaches. We then evaluate the efficacy of these three alternatives empirically. We conclude that the model robust criteria generally lead to improved robustness; however, the increased robustness can come at a significant cost in terms of computing requirements.
Topic revision: r3 - 26 Apr 2013, JohnBock

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