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- To illustrate the basic logic behind hypothesis testing using a simple example.
- To discuss the notion of a null and alternative hypothesis.
- To discuss the notion of a P-value and statistical power.
- To demonstrate how sample size can influence statistical power.
- To illustrate the use of a confidence interval.

- K&S Chapters 5-9, Sections 30.2, 33.1, 33.2, 35.1-35.4,
**35.6**, 35.7

- normal distribution
- central limit theorem
- large sample / small sample
- confidence interval
- hypothesis test
- type I error, type II error, power, value

- paired test
- z test, t test, ANOVA
- fixed effects / random effects
- nonparametric methods
- Bayesian statistics
- sample size calculation

- Sung JJ, Chung SC, Lai CW, Chan FK, Leung JW, Yung My, Kassianides C, Li AK, "Octreotide infusion or emergency sclerotherapy for variceal haemorrhage,"
*Lancet*, 342 : 637-41, 1993. pdf here - Newnham JP, Evans SF, Michael CA, Stanley FJ, Landau LI, "Effects of frequent ultrasound during pregnancy: a randomised controlled trial,"
*Lancet*, 342: 887-81, 1993. pdf here

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Topic revision: r14 - 15 Dec 2009, TheresaScott

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