Ph.D. in Biostatistics, March 2005
  • The Johns Hopkins University, Department of Biotatistics, Baltimore MD
  • Advisor: Assistant Professor Brian S. Caffo
  • Co-advisor: Professor Charles Rohde
  • Thesis Title "Modelling Biomedical Data and the Foundations of Bioequivalence"
M.S. in Physical Pharmacy, February 1995
  • Seoul National University School of Pharmacy, Seoul, Korea
  • Thesis Title "Solubilization of Cyclosporin A using Liposomes and Mixed Micelles, and Pharmacokinetics after Intravenous Administration"
B.S. in Pharmacy, February 1988
  • Seoul National University School of Pharmacy, Seoul, Korea

Professional Experience

Assistant Professor, September 2005-Present
  • Vanderbilt University, Department of Biostatistics
Statistical Consultant, 2000 - 2005
  • Johns Hopkins Biostatistics Consulting Center
    • Statistical short courses
      • Nonlinear mixed models in pharmaceutical research: a case study with real data, July 24, 2002
      • Nonlinear mixed models for pharmacokinetics and pharmacodynamics: application to QT data, December 11, 2002
    • Walk-in clinic
  • Dr. Craig W. Hendrix group, Johns Hopkins School of Medicine, Department of Clinical Pharmacology
  • Dr. Jennifer Haythornthwaite group, Johns Hopkins School of Medicine, Department of Psychiatry-Behavioral Medicine Clinic
  • Dr. Gary Wand group, Johns Hopkins School of Medicine, Department of Medicine and Psychiatry
Regulatory Agent, 1995-1999
  • Korea Food and Drug Administration, Seoul, Korea
Pharmacist, 1990-1991
  • Daehak Drug Store, Seoul, Korea
Reporter, 1989-1990
  • The Journal of Clinical Pharmacy, Seoul, Korea
Volunteer Worker, 1987-1988
  • The Anglican Church, Youngdung-po, Seoul, Korea

Research Interests

Interesting problems involving pharmacokinetic and pharmacodynamic modelling, Bioequivalence and Structural modelling (Mechanistic modelling)

Peer Reviewed Publications

  1. Choi, L., Dominici, F., Zeger, S.L. and Ouyang, P. Estimating Treatment Efficacy over Time: a Logistic Regression Model for Binary Longitudinal Outcomes. Statistics in Medicine, 24:2789-2805, 2005.
  2. Lee, M.K., Choi, L., Kim, M.H. and Kim, C.K. Pharmacokinetics and Organ Distribution of Cyclosporin A Incorporated in Liposomes and Mixed Micelles. International Journal of Pharmaceutics, 191:87-93, 1999.
  3. Kim, C.K., Chung, H.S., Lee, M.K., Choi, L.N. and Kim, M.H. Development of Dried Liposomes Containing β-Galactosidase for the Digestion of Lactose in Milk. International Journal of Pharmaceutics, 183:185-193, 1999.

Peer Reviewed Collaborative Publications

  1. Ndovi, T.T., Choi, L., Caffo, B., Parsons, T., Baker, S., Zhao, M., Rohde, C. and Hendrix, C.W. Quantitative assessment of seminal vesicle and prostate drug concentrations by use of a noninvasive method. Clinical Pharmacology and Therapeutics, 80(2): 146-158, 2006.
  2. Oswald, L.M., Wong, D.F., Trash.McCaul, M., Zhou, Y., Kuwabara, H., Choi, L., Brasic, J. and Wand, G.S. Relationships among ventral striatal dopamine release, cortisol secretion and subjective responses to amphetamine. Neuropsychopharmacology, 30(4), 821-832, 2005.
  3. Uhart, M., Trash.McCaul, M., Oswald, L.M., Choi, L. and Wand, G.S. GABRA6 gene polymorphism and an attenuated stress response. Molecular Psychiatry, 9(11):998-1006, 2004.
  4. Oswald, L.M., Trash.McCaul, M., Choi, L., Yang, X. and Wand, G.S. Catechol-O-methyltransferase polymorphism alters hypothalamic-pituitary-adrenal axis responses to naloxone: a preliminary report. Biological Psychiatry, 55(1):102-105, 2004.
  5. Lawler, L.P., Horton, K.M., Scatarige, J.C., Phelps, J., Thompson, R.E., Choi, L. and Fishman, E.K. Coronary artery calcification scoring by prospectively triggered multidetector-row computed tomography: is it reproducible? Journal of Computer Assisted Tomography, 28(1):40-45, 2004.

Manuscripts under review/revisions and technical reports

  1. Choi, L., Caffo, B.S., Rohde, C., Ndovi, T.T. and Hendrix, C.W. A Mechanistic Latent Variable Model for Estimating Drug Concentrations in the Male Genital Tract. Technical Report. Download a copy here.
  2. Choi, L., Caffo, B.S. and Rohde, C. Optimal Sampling Times in Bioequivalence Studies Using a Simulated Annealing Algorithm. Technical Report. Download a copy here.


  • A case study for estimating efficacy of a stomach disorder treatment in clinical trials. Jonhs Hopkins University Bloomberg School of Public Health Department of Biostatistics 2003 Retreat, April 25-27, 2003.
  • Evaluation for the Reference Standards of Glipizide and Glibenclamide. 1996 Research Presentation, Korea Food and Drug Administration, 4 February, 1997.
  • Development of Dry Liposomes Containing β-Galactosidase for the Digestion of Lactose in Milk. Liposome Research Days Conference - Liposomes: the Next Generation, University of British Columbia, Vancouver, Canada, 19 June - 22 June, 1994.

Awards, Honors and Liscences

  • Phi Beta Kappa, May 2005.
  • Korea Food and Drug Administration Best Presentation Award from the Commissioner of Korea Food and Drug Administration, February 1997.
  • Registered air environmental engineer, Korea, July 24 1995.
  • Registered pharmacist, Korea, March 13 1989.
Topic revision: r10 - 29 Jul 2008, JohnHarrell

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