Department of Biostatistics Seminar/Workshop Series

A Case Study in Pharmacologic Colon Imaging Using Principal Curves in Single Photon Emission Computed Tomography

Brian S. Caffo, PhD

Associate Professor, Department of Biostatistics
Johns Hopkins University

Wednesday, March 6, 2008, 1:30-2:30pm, MRBIII Conference Room 1220

Intended Audience: Persons interested in applied statistics, statistical theory, epidemiology, health services research, clinical trials methodology, statistical computing, statistical graphics, R users or potential users

In this talk we consider functional imaging of the colon to assess the kinetics of a microbicide lubricant. The overarching goal is to understand the penetration of the lubricant after anal coitus. Such information is crucial for understanding the potential impact of the microbicide on viral transmission. The experiment was conducted by simulating coitus in a subject after injecting a radiolabeled lubricant. After coital simulation, the subject was imaged via Single photon emission computed tomography (SPECT), a non-invasive, in-vivo functional imaging technique. We use a highly modified version of the principal curve algorithm to construct a three dimensional curve through the colon images. The algorithm is developed on several difficult two dimensional images of familiar curves. The final curve fit the colon data is compared to experimental sigmoidoscope collection.

Presenter Information
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Topic revision: r1 - 04 Jan 2008, DianeKolb

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