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- Syllabus from a course on Biostatistical Modeling (updated 9Jan03; click here for a pdf file for printing), lecture notes, concepts to master and supplemental notes (6 pages; updated 26Jan99)
- Homework assignments
- Problems with categorizing continuous variables
- Some useful equations for linear regression (26Jan99, PDF, 3 pages)
- Handouts on ordinary least squares regression and regression diagnostics by Jim Patrie (20Mar01, PDF, 73 pages)

- S scripts demonstrating various modeling building blocks.
- Interactive demonstration for a single predictor: linear and quadratic fit, categorization, addition of noise, and power
- Requires running in RStudio as well as the Hmisc package

- Curve fitting for a single predictor: least squares, least sum of absolute deviations, least median squared deviation, loess (requires Hmisc and MASS packages, updated 25Dec12)
- Fitting linear, linear spline, quartic polynomial, unrestricted cubic spline, and restricted cubic spline functions for a single predictor (requires Hmisc and rms packages, 25Dec12); see also here
- Random examples of restricted cubic spline functions with 3 - 7 knots (requires Hmisc package, 25Feb99)
- Miscellaneous examples of splines and effects of changing knots
- Demonstration of loess details by Greg Snow, BYU

- Interactive demonstration for a single predictor: linear and quadratic fit, categorization, addition of noise, and power
- Example of using restricted cubic spline functions to model time-response profiles from serially collected patient data (hormone levels from blood draws every 10 minutes in each subject)
- Cluster bootstrap used to get confidence intervals accounting for intra-subject correlation
- Bootstrap bumping used to get simultaneous confidence bands
- Estimates and bands are for the difference in time-response mean profiles for older vs. younger subjects
- Analyses done using R
`Hmisc`

package function`rm.boot`

- Kevin Quinn's web site on logistic regression and log-linear modeling (has good examples of the S
`glm`

function and some Bayesian methods) - Binary logistic regression example from basic biomedical research showing a fit with and without interaction (Wenger et al, Can J Physiol Pharmacol 62:224, 1984)
- Ordinary Least Squares Regression and Regression Diagnostics (Jim Patrie, 20Mar01, 73 pages)
- Notes of problems in using ratios as dependent variables, from Rich Goldstein (15Jul99)
- Use of the Cox Semiparametric Regression Model for Predicting Costs, Charges, and Length of Stay; FE Harrell and LR Smith;Short Course, Meeting on Methodologic Issues in Health Services and Outcomes Research, 3Dec95)
- REGRESSION MODELING STRATEGIES with Applications to Linear Models, Logistic Regression, and Survival Analysis, Book and Short Courses by FE Harrell.
- MSCI Biostatistics II Course
- R-based site for rank-based linear models by Abebe, Crimin,
McKean, Haas, Vidmar (see Drug Information Journal 35:947-971, 2001). - Doug Bates' presentation Using Open Source Software to Teach Mathematical Statistics, with examples of distribution fitting using maximum likelihood, profile likelihood plotting, and other statistical calculations
- University of Otago's student tutorials on Monte Carlo methods, principal components analysis, the bootstrap, clustering,

- TRIPOD: Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD): Explanation and Elaboration

-- ColeBeck - 09 Mar 2004

I | Attachment | Action | Size | Date | Who | Comment |
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html | biomod.html | manage | 20.6 K | 09 Mar 2004 - 16:03 | ColeBeck | |

biomod.pdf | manage | 98.0 K | 09 Mar 2004 - 16:03 | ColeBeck | ||

biostatModHw.pdf | manage | 80.4 K | 10 Mar 2004 - 08:42 | ColeBeck | ||

html | concepts.html | manage | 3.4 K | 09 Mar 2004 - 16:03 | ColeBeck | |

formulas.pdf | manage | 99.8 K | 09 Mar 2004 - 16:04 | ColeBeck | ||

goldstein.ratios.pdf | manage | 109.4 K | 09 Mar 2004 - 16:20 | ColeBeck | ||

hpstat95.pdf | manage | 599.8 K | 09 Mar 2004 - 16:20 | ColeBeck | ||

ssc | loess.demo.ssc | manage | 2.4 K | 09 Mar 2004 - 16:05 | ColeBeck | |

patrie.regression.pdf | manage | 381.3 K | 09 Mar 2004 - 16:06 | ColeBeck | ||

ssc | rcspline.examples.ssc | manage | 0.7 K | 09 Mar 2004 - 16:05 | ColeBeck | |

suppnotes.pdf | manage | 143.0 K | 09 Mar 2004 - 16:03 | ColeBeck | ||

r | catgNoise.r | manage | 4.5 K | 29 May 2011 - 09:33 | FrankHarrell | Interactive demonstration in RStudio: power with categorization and noise |

r | demo.least.squares.r | manage | 1.0 K | 25 Dec 2012 - 13:42 | FrankHarrell | Demo of linear fits using least squares and robust fits, and loess |

r | demo.spline.r | manage | 1.9 K | 25 Dec 2012 - 13:25 | FrankHarrell | Interactive demo of spline and polynomial fitting |

hart3.pdf | manage | 50.6 K | 16 Apr 2008 - 22:18 | FrankHarrell | Example of simultaneous confidence bands for difference in two time-response curves | |

notes.pdf | manage | 1405.3 K | 02 Jan 2008 - 16:02 | FrankHarrell | Biostatistical Modeling Notes | |

png | vfib.png | manage | 124.1 K | 07 Apr 2008 - 17:41 | FrankHarrell | Binary logistic regression example from Regression Modeling Strategies |

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Topic revision: r18 - 10 Jan 2015, FrankHarrell

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