-- KathrynStoltzfus - 05 Feb 2018

In development and adulthood, cognitive symptoms of disorders and disease are preceded by neuroanatomical abnormalities that are indicative of vulnerability. There are growing bodies of literature identifying neuroanatomical markers of mood disorders in adolescence and dementia in adulthood. Because prevention is an increasing target of intervention, establishing early biomarkers is critical to identify individuals who are at risk and may benefit from early therapy. Neuroimaging provides diverse measurements of neurological features that may serve as biomarkers of disease. In this talk, we will discuss two new tools for performing association tests in neuroimaging studies that we use to explore development and disease at two periods of risk in the lifespan. We propose a robust procedure to perform “mass-univariate testing” and develop a novel framework for association testing that serves as an alternative to the classical mass-univariate approach. Our methods are solutions to assumption violations of classical procedures that have led to inflated type 1 error rates in neuroimaging studies.
Topic revision: r1 - 05 Feb 2018, KathrynStoltzfus

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